| Full name: F2R like trypsin receptor 1 | Alias Symbol: PAR2 | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 2150 | HGNC ID: HGNC:3538 | Ensembl Gene: ENSG00000164251 | OMIM ID: 600933 |
| Drug and gene relationship at DGIdb | |||
F2RL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of F2RL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F2RL1 | 2150 | 213506_at | -0.0538 | 0.9770 | |
| GSE20347 | F2RL1 | 2150 | 213506_at | -0.1556 | 0.6695 | |
| GSE23400 | F2RL1 | 2150 | 213506_at | 0.6557 | 0.0020 | |
| GSE26886 | F2RL1 | 2150 | 213506_at | 0.3653 | 0.5078 | |
| GSE29001 | F2RL1 | 2150 | 213506_at | 0.6298 | 0.2711 | |
| GSE38129 | F2RL1 | 2150 | 213506_at | 0.9478 | 0.0351 | |
| GSE45670 | F2RL1 | 2150 | 213506_at | 1.1961 | 0.0001 | |
| GSE53622 | F2RL1 | 2150 | 56338 | -0.2178 | 0.0000 | |
| GSE53624 | F2RL1 | 2150 | 56338 | -0.1720 | 0.0087 | |
| GSE63941 | F2RL1 | 2150 | 213506_at | 1.2344 | 0.0073 | |
| GSE77861 | F2RL1 | 2150 | 213506_at | 1.2894 | 0.0053 | |
| GSE97050 | F2RL1 | 2150 | A_33_P3232945 | 0.9871 | 0.1065 | |
| SRP007169 | F2RL1 | 2150 | RNAseq | 0.8268 | 0.0196 | |
| SRP008496 | F2RL1 | 2150 | RNAseq | 0.3642 | 0.3916 | |
| SRP064894 | F2RL1 | 2150 | RNAseq | 0.7314 | 0.0284 | |
| SRP133303 | F2RL1 | 2150 | RNAseq | 0.5470 | 0.0836 | |
| SRP159526 | F2RL1 | 2150 | RNAseq | 0.9923 | 0.0337 | |
| SRP193095 | F2RL1 | 2150 | RNAseq | -0.8086 | 0.0074 | |
| SRP219564 | F2RL1 | 2150 | RNAseq | -0.3237 | 0.7441 | |
| TCGA | F2RL1 | 2150 | RNAseq | 0.0748 | 0.5860 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by F2RL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F2RL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F2RL1 | 2150 | 1 | 13 | 16 | |
| GSE20123 | F2RL1 | 2150 | 1 | 13 | 16 | |
| GSE43470 | F2RL1 | 2150 | 1 | 13 | 29 | |
| GSE46452 | F2RL1 | 2150 | 0 | 28 | 31 | |
| GSE47630 | F2RL1 | 2150 | 1 | 19 | 20 | |
| GSE54993 | F2RL1 | 2150 | 8 | 1 | 61 | |
| GSE54994 | F2RL1 | 2150 | 1 | 19 | 33 | |
| GSE60625 | F2RL1 | 2150 | 0 | 0 | 11 | |
| GSE74703 | F2RL1 | 2150 | 1 | 9 | 26 | |
| GSE74704 | F2RL1 | 2150 | 1 | 6 | 13 | |
| TCGA | F2RL1 | 2150 | 5 | 49 | 42 |
Total number of gains: 20; Total number of losses: 170; Total Number of normals: 298.
Somatic mutations of F2RL1:
Generating mutation plots.
Highly correlated genes for F2RL1:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F2RL1 | KDM1B | 0.780612 | 3 | 0 | 3 |
| F2RL1 | CDCA2 | 0.768615 | 3 | 0 | 3 |
| F2RL1 | TMEM92 | 0.765559 | 3 | 0 | 3 |
| F2RL1 | USP40 | 0.745729 | 3 | 0 | 3 |
| F2RL1 | TENM2 | 0.743085 | 4 | 0 | 3 |
| F2RL1 | ARNTL2 | 0.74167 | 3 | 0 | 3 |
| F2RL1 | PPP1R21 | 0.740885 | 3 | 0 | 3 |
| F2RL1 | WNT10A | 0.740875 | 3 | 0 | 3 |
| F2RL1 | EPPK1 | 0.739134 | 4 | 0 | 4 |
| F2RL1 | MRPL14 | 0.732671 | 3 | 0 | 3 |
| F2RL1 | DCBLD1 | 0.72968 | 4 | 0 | 4 |
| F2RL1 | TOP1MT | 0.728744 | 3 | 0 | 3 |
| F2RL1 | TRAF3 | 0.722336 | 3 | 0 | 3 |
| F2RL1 | TOR1A | 0.722205 | 3 | 0 | 3 |
| F2RL1 | DDX55 | 0.72155 | 3 | 0 | 3 |
| F2RL1 | POLR2G | 0.720842 | 3 | 0 | 3 |
| F2RL1 | DNAH14 | 0.719732 | 3 | 0 | 3 |
| F2RL1 | ALAS1 | 0.717167 | 3 | 0 | 3 |
| F2RL1 | FABP4 | 0.716426 | 3 | 0 | 3 |
| F2RL1 | CRIPT | 0.714817 | 4 | 0 | 4 |
For details and further investigation, click here
