| Full name: Zic family member 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q32.3 | ||
| Entrez ID: 85416 | HGNC ID: HGNC:20322 | Ensembl Gene: ENSG00000139800 | OMIM ID: 617896 |
| Drug and gene relationship at DGIdb | |||
Expression of ZIC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZIC5 | 85416 | 1552938_at | 0.2135 | 0.7388 | |
| GSE26886 | ZIC5 | 85416 | 1552938_at | 0.1539 | 0.1713 | |
| GSE45670 | ZIC5 | 85416 | 1552938_at | 0.0657 | 0.6209 | |
| GSE53622 | ZIC5 | 85416 | 55524 | 3.6813 | 0.0000 | |
| GSE53624 | ZIC5 | 85416 | 55524 | 4.6786 | 0.0000 | |
| GSE63941 | ZIC5 | 85416 | 1552938_at | 0.6193 | 0.1137 | |
| GSE77861 | ZIC5 | 85416 | 1552938_at | -0.0189 | 0.8729 | |
| GSE97050 | ZIC5 | 85416 | A_32_P219942 | 0.4515 | 0.2395 | |
| SRP007169 | ZIC5 | 85416 | RNAseq | 3.3388 | 0.0001 | |
| SRP133303 | ZIC5 | 85416 | RNAseq | 2.4662 | 0.0000 | |
| SRP159526 | ZIC5 | 85416 | RNAseq | 7.3381 | 0.0000 | |
| TCGA | ZIC5 | 85416 | RNAseq | 3.0807 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by ZIC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZIC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZIC5 | 85416 | 3 | 9 | 18 | |
| GSE20123 | ZIC5 | 85416 | 3 | 8 | 19 | |
| GSE43470 | ZIC5 | 85416 | 4 | 12 | 27 | |
| GSE46452 | ZIC5 | 85416 | 0 | 32 | 27 | |
| GSE47630 | ZIC5 | 85416 | 3 | 26 | 11 | |
| GSE54993 | ZIC5 | 85416 | 11 | 4 | 55 | |
| GSE54994 | ZIC5 | 85416 | 6 | 10 | 37 | |
| GSE60625 | ZIC5 | 85416 | 0 | 3 | 8 | |
| GSE74703 | ZIC5 | 85416 | 3 | 10 | 23 | |
| GSE74704 | ZIC5 | 85416 | 1 | 8 | 11 | |
| TCGA | ZIC5 | 85416 | 17 | 34 | 45 |
Total number of gains: 51; Total number of losses: 156; Total Number of normals: 281.
Somatic mutations of ZIC5:
Generating mutation plots.
Highly correlated genes for ZIC5:
Showing top 20/593 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZIC5 | UBE2T | 0.798714 | 3 | 0 | 3 |
| ZIC5 | KIF14 | 0.792485 | 3 | 0 | 3 |
| ZIC5 | SPAG5 | 0.789553 | 3 | 0 | 3 |
| ZIC5 | ZIC2 | 0.778224 | 4 | 0 | 4 |
| ZIC5 | UBE2C | 0.775312 | 3 | 0 | 3 |
| ZIC5 | KNTC1 | 0.774816 | 3 | 0 | 3 |
| ZIC5 | FANCB | 0.774488 | 3 | 0 | 3 |
| ZIC5 | LAPTM4B | 0.767525 | 3 | 0 | 3 |
| ZIC5 | PSMB3 | 0.764803 | 3 | 0 | 3 |
| ZIC5 | DTL | 0.762708 | 3 | 0 | 3 |
| ZIC5 | TOP2A | 0.761634 | 3 | 0 | 3 |
| ZIC5 | TPX2 | 0.758758 | 3 | 0 | 3 |
| ZIC5 | PYCR2 | 0.754324 | 3 | 0 | 3 |
| ZIC5 | ASPM | 0.753005 | 3 | 0 | 3 |
| ZIC5 | ATP2C1 | 0.748478 | 3 | 0 | 3 |
| ZIC5 | AURKA | 0.745258 | 3 | 0 | 3 |
| ZIC5 | BIRC5 | 0.744225 | 3 | 0 | 3 |
| ZIC5 | TIMELESS | 0.743281 | 3 | 0 | 3 |
| ZIC5 | PRKDC | 0.742416 | 3 | 0 | 3 |
| ZIC5 | CENPE | 0.741001 | 3 | 0 | 3 |
For details and further investigation, click here
