| Full name: leucine carboxyl methyltransferase 2 | Alias Symbol: KIAA0547|MGC9534|TYW4|PPM2 | ||
| Type: protein-coding gene | Cytoband: 15q15.3 | ||
| Entrez ID: 9836 | HGNC ID: HGNC:17558 | Ensembl Gene: ENSG00000168806 | OMIM ID: 611246 |
| Drug and gene relationship at DGIdb | |||
Expression of LCMT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCMT2 | 9836 | 204012_s_at | 0.0458 | 0.9555 | |
| GSE20347 | LCMT2 | 9836 | 204012_s_at | -0.0364 | 0.7158 | |
| GSE23400 | LCMT2 | 9836 | 204012_s_at | -0.0250 | 0.7177 | |
| GSE26886 | LCMT2 | 9836 | 204012_s_at | -0.0597 | 0.8301 | |
| GSE29001 | LCMT2 | 9836 | 204012_s_at | -0.0473 | 0.8636 | |
| GSE38129 | LCMT2 | 9836 | 204012_s_at | 0.0101 | 0.9322 | |
| GSE45670 | LCMT2 | 9836 | 204012_s_at | -0.1180 | 0.4407 | |
| GSE53622 | LCMT2 | 9836 | 124894 | -0.2226 | 0.0051 | |
| GSE53624 | LCMT2 | 9836 | 124894 | -0.2626 | 0.0000 | |
| GSE63941 | LCMT2 | 9836 | 204012_s_at | -0.0200 | 0.9732 | |
| GSE77861 | LCMT2 | 9836 | 204012_s_at | 0.0415 | 0.8841 | |
| GSE97050 | LCMT2 | 9836 | A_23_P106505 | -0.1826 | 0.4310 | |
| SRP007169 | LCMT2 | 9836 | RNAseq | -1.0948 | 0.0073 | |
| SRP008496 | LCMT2 | 9836 | RNAseq | -0.9843 | 0.0003 | |
| SRP064894 | LCMT2 | 9836 | RNAseq | -0.5273 | 0.0014 | |
| SRP133303 | LCMT2 | 9836 | RNAseq | -0.0958 | 0.4366 | |
| SRP159526 | LCMT2 | 9836 | RNAseq | -0.0389 | 0.8687 | |
| SRP193095 | LCMT2 | 9836 | RNAseq | -0.0602 | 0.5278 | |
| SRP219564 | LCMT2 | 9836 | RNAseq | -0.4285 | 0.2406 | |
| TCGA | LCMT2 | 9836 | RNAseq | -0.0267 | 0.7341 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LCMT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCMT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCMT2 | 9836 | 4 | 4 | 22 | |
| GSE20123 | LCMT2 | 9836 | 4 | 5 | 21 | |
| GSE43470 | LCMT2 | 9836 | 3 | 5 | 35 | |
| GSE46452 | LCMT2 | 9836 | 3 | 7 | 49 | |
| GSE47630 | LCMT2 | 9836 | 8 | 10 | 22 | |
| GSE54993 | LCMT2 | 9836 | 4 | 6 | 60 | |
| GSE54994 | LCMT2 | 9836 | 5 | 7 | 41 | |
| GSE60625 | LCMT2 | 9836 | 4 | 0 | 7 | |
| GSE74703 | LCMT2 | 9836 | 3 | 3 | 30 | |
| GSE74704 | LCMT2 | 9836 | 3 | 2 | 15 | |
| TCGA | LCMT2 | 9836 | 12 | 17 | 67 |
Total number of gains: 53; Total number of losses: 66; Total Number of normals: 369.
Somatic mutations of LCMT2:
Generating mutation plots.
Highly correlated genes for LCMT2:
Showing top 20/200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCMT2 | SNX18 | 0.750297 | 3 | 0 | 3 |
| LCMT2 | DDX20 | 0.741778 | 3 | 0 | 3 |
| LCMT2 | MLST8 | 0.735181 | 3 | 0 | 3 |
| LCMT2 | LMBRD2 | 0.732707 | 3 | 0 | 3 |
| LCMT2 | FBXO11 | 0.727917 | 4 | 0 | 3 |
| LCMT2 | CAND1 | 0.720854 | 3 | 0 | 3 |
| LCMT2 | APOO | 0.719724 | 3 | 0 | 3 |
| LCMT2 | COQ3 | 0.718346 | 3 | 0 | 3 |
| LCMT2 | GK5 | 0.713999 | 3 | 0 | 3 |
| LCMT2 | DIP2B | 0.712682 | 3 | 0 | 3 |
| LCMT2 | SNAPC3 | 0.703143 | 3 | 0 | 3 |
| LCMT2 | DHX57 | 0.702278 | 3 | 0 | 3 |
| LCMT2 | FAN1 | 0.698428 | 4 | 0 | 3 |
| LCMT2 | PDE6D | 0.698134 | 3 | 0 | 3 |
| LCMT2 | MRPL49 | 0.697587 | 3 | 0 | 3 |
| LCMT2 | DIS3L | 0.690397 | 4 | 0 | 4 |
| LCMT2 | ERCC6 | 0.680079 | 3 | 0 | 3 |
| LCMT2 | CEP70 | 0.679363 | 3 | 0 | 3 |
| LCMT2 | SMC2 | 0.675805 | 3 | 0 | 3 |
| LCMT2 | CRNKL1 | 0.667553 | 3 | 0 | 3 |
For details and further investigation, click here
