| Full name: Fc fragment of IgG receptor IIb | Alias Symbol: CD32|CD32B | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 2213 | HGNC ID: HGNC:3618 | Ensembl Gene: ENSG00000072694 | OMIM ID: 604590 |
| Drug and gene relationship at DGIdb | |||
FCGR2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa05150 | Staphylococcus aureus infection | |
| hsa05152 | Tuberculosis | |
| hsa05162 | Measles |
Expression of FCGR2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCGR2B | 2213 | 210889_s_at | -0.5631 | 0.6504 | |
| GSE20347 | FCGR2B | 2213 | 210889_s_at | -0.1006 | 0.5759 | |
| GSE23400 | FCGR2B | 2213 | 210889_s_at | -0.1741 | 0.0394 | |
| GSE26886 | FCGR2B | 2213 | 210889_s_at | -0.5708 | 0.0010 | |
| GSE29001 | FCGR2B | 2213 | 210889_s_at | -0.1099 | 0.6086 | |
| GSE38129 | FCGR2B | 2213 | 210889_s_at | -0.3635 | 0.2042 | |
| GSE45670 | FCGR2B | 2213 | 210889_s_at | -1.2647 | 0.0014 | |
| GSE53622 | FCGR2B | 2213 | 122841 | -0.2896 | 0.0154 | |
| GSE53624 | FCGR2B | 2213 | 122841 | -0.3632 | 0.0162 | |
| GSE63941 | FCGR2B | 2213 | 210889_s_at | 0.0306 | 0.8547 | |
| GSE77861 | FCGR2B | 2213 | 210889_s_at | 0.1007 | 0.5677 | |
| GSE97050 | FCGR2B | 2213 | A_23_P34644 | 0.4125 | 0.2290 | |
| SRP007169 | FCGR2B | 2213 | RNAseq | -0.2638 | 0.6444 | |
| SRP008496 | FCGR2B | 2213 | RNAseq | -0.1851 | 0.6393 | |
| SRP064894 | FCGR2B | 2213 | RNAseq | 0.0845 | 0.8130 | |
| SRP133303 | FCGR2B | 2213 | RNAseq | -0.1287 | 0.7082 | |
| SRP159526 | FCGR2B | 2213 | RNAseq | -0.3622 | 0.6768 | |
| SRP193095 | FCGR2B | 2213 | RNAseq | 0.0623 | 0.7614 | |
| SRP219564 | FCGR2B | 2213 | RNAseq | 0.3933 | 0.4973 | |
| TCGA | FCGR2B | 2213 | RNAseq | -0.1623 | 0.4521 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FCGR2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCGR2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCGR2B | 2213 | 10 | 0 | 20 | |
| GSE20123 | FCGR2B | 2213 | 10 | 0 | 20 | |
| GSE43470 | FCGR2B | 2213 | 7 | 2 | 34 | |
| GSE46452 | FCGR2B | 2213 | 2 | 1 | 56 | |
| GSE47630 | FCGR2B | 2213 | 14 | 0 | 26 | |
| GSE54993 | FCGR2B | 2213 | 0 | 5 | 65 | |
| GSE54994 | FCGR2B | 2213 | 16 | 0 | 37 | |
| GSE60625 | FCGR2B | 2213 | 0 | 0 | 11 | |
| GSE74703 | FCGR2B | 2213 | 7 | 2 | 27 | |
| GSE74704 | FCGR2B | 2213 | 4 | 0 | 16 | |
| TCGA | FCGR2B | 2213 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of FCGR2B:
Generating mutation plots.
Highly correlated genes for FCGR2B:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCGR2B | MPEG1 | 0.729351 | 7 | 0 | 7 |
| FCGR2B | CCL3 | 0.726281 | 3 | 0 | 3 |
| FCGR2B | CMKLR1 | 0.713651 | 5 | 0 | 5 |
| FCGR2B | NRROS | 0.706375 | 4 | 0 | 4 |
| FCGR2B | FAT4 | 0.698054 | 4 | 0 | 4 |
| FCGR2B | RNASE2 | 0.697582 | 3 | 0 | 3 |
| FCGR2B | ENPP2 | 0.694692 | 7 | 0 | 6 |
| FCGR2B | GIMAP6 | 0.687888 | 11 | 0 | 10 |
| FCGR2B | IL10RA | 0.68395 | 9 | 0 | 8 |
| FCGR2B | OLFML1 | 0.683401 | 7 | 0 | 7 |
| FCGR2B | VSIG4 | 0.664821 | 10 | 0 | 8 |
| FCGR2B | CR1 | 0.663634 | 5 | 0 | 4 |
| FCGR2B | C3 | 0.657745 | 9 | 0 | 8 |
| FCGR2B | FBN1 | 0.657491 | 4 | 0 | 4 |
| FCGR2B | PECAM1 | 0.65749 | 10 | 0 | 10 |
| FCGR2B | CDH5 | 0.656518 | 7 | 0 | 7 |
| FCGR2B | CSF1R | 0.656429 | 12 | 0 | 11 |
| FCGR2B | C1orf162 | 0.655405 | 8 | 0 | 6 |
| FCGR2B | ZFPM2 | 0.653593 | 6 | 0 | 6 |
| FCGR2B | S100A4 | 0.653209 | 7 | 0 | 6 |
For details and further investigation, click here
