| Full name: cadherin 5 | Alias Symbol: 7B4|CD144 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 1003 | HGNC ID: HGNC:1764 | Ensembl Gene: ENSG00000179776 | OMIM ID: 601120 |
| Drug and gene relationship at DGIdb | |||
CDH5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04670 | Leukocyte transendothelial migration |
Expression of CDH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDH5 | 1003 | 204677_at | -0.1632 | 0.8584 | |
| GSE20347 | CDH5 | 1003 | 204677_at | -0.2211 | 0.0345 | |
| GSE23400 | CDH5 | 1003 | 204677_at | -0.0183 | 0.8550 | |
| GSE26886 | CDH5 | 1003 | 204677_at | 0.0606 | 0.7590 | |
| GSE29001 | CDH5 | 1003 | 204677_at | -0.1322 | 0.5402 | |
| GSE38129 | CDH5 | 1003 | 204677_at | -0.4142 | 0.1648 | |
| GSE45670 | CDH5 | 1003 | 204677_at | -0.6746 | 0.0643 | |
| GSE53622 | CDH5 | 1003 | 24850 | -0.4558 | 0.0000 | |
| GSE53624 | CDH5 | 1003 | 24850 | -0.0988 | 0.1597 | |
| GSE63941 | CDH5 | 1003 | 204677_at | 0.7931 | 0.4561 | |
| GSE77861 | CDH5 | 1003 | 204677_at | 0.0581 | 0.6846 | |
| GSE97050 | CDH5 | 1003 | A_33_P3728167 | 0.5015 | 0.1726 | |
| SRP007169 | CDH5 | 1003 | RNAseq | 0.8493 | 0.0445 | |
| SRP008496 | CDH5 | 1003 | RNAseq | 0.9714 | 0.0266 | |
| SRP064894 | CDH5 | 1003 | RNAseq | 0.6839 | 0.0643 | |
| SRP133303 | CDH5 | 1003 | RNAseq | -0.5174 | 0.0372 | |
| SRP159526 | CDH5 | 1003 | RNAseq | 0.0775 | 0.8551 | |
| SRP193095 | CDH5 | 1003 | RNAseq | 0.9854 | 0.0000 | |
| SRP219564 | CDH5 | 1003 | RNAseq | 0.1671 | 0.7883 | |
| TCGA | CDH5 | 1003 | RNAseq | -0.3910 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDH5 | 1003 | 6 | 1 | 23 | |
| GSE20123 | CDH5 | 1003 | 7 | 1 | 22 | |
| GSE43470 | CDH5 | 1003 | 1 | 8 | 34 | |
| GSE46452 | CDH5 | 1003 | 38 | 1 | 20 | |
| GSE47630 | CDH5 | 1003 | 10 | 8 | 22 | |
| GSE54993 | CDH5 | 1003 | 2 | 4 | 64 | |
| GSE54994 | CDH5 | 1003 | 8 | 10 | 35 | |
| GSE60625 | CDH5 | 1003 | 4 | 0 | 7 | |
| GSE74703 | CDH5 | 1003 | 1 | 5 | 30 | |
| GSE74704 | CDH5 | 1003 | 4 | 0 | 16 | |
| TCGA | CDH5 | 1003 | 30 | 11 | 55 |
Total number of gains: 111; Total number of losses: 49; Total Number of normals: 328.
Somatic mutations of CDH5:
Generating mutation plots.
Highly correlated genes for CDH5:
Showing top 20/544 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDH5 | CLEC14A | 0.727163 | 7 | 0 | 6 |
| CDH5 | ANGPTL2 | 0.719979 | 7 | 0 | 7 |
| CDH5 | COL15A1 | 0.70984 | 11 | 0 | 11 |
| CDH5 | CD93 | 0.704913 | 12 | 0 | 10 |
| CDH5 | ICAM2 | 0.704241 | 6 | 0 | 5 |
| CDH5 | ESAM | 0.698456 | 4 | 0 | 4 |
| CDH5 | SNX25 | 0.69632 | 3 | 0 | 3 |
| CDH5 | PECAM1 | 0.695716 | 13 | 0 | 10 |
| CDH5 | GNG11 | 0.692236 | 12 | 0 | 11 |
| CDH5 | TIE1 | 0.688224 | 12 | 0 | 8 |
| CDH5 | RAMP3 | 0.687729 | 10 | 0 | 10 |
| CDH5 | ECSCR | 0.68642 | 8 | 0 | 8 |
| CDH5 | DCHS1 | 0.685103 | 7 | 0 | 6 |
| CDH5 | VWF | 0.683107 | 11 | 0 | 10 |
| CDH5 | ENPP2 | 0.681264 | 7 | 0 | 6 |
| CDH5 | MMRN2 | 0.679104 | 8 | 0 | 7 |
| CDH5 | EBF1 | 0.675465 | 6 | 0 | 5 |
| CDH5 | IFFO1 | 0.67368 | 5 | 0 | 5 |
| CDH5 | THBS4 | 0.671082 | 4 | 0 | 3 |
| CDH5 | IFITM2 | 0.670446 | 5 | 0 | 3 |
For details and further investigation, click here
