| Full name: ectonucleotide pyrophosphatase/phosphodiesterase 2 | Alias Symbol: ATX|PD-IALPHA | ||
| Type: protein-coding gene | Cytoband: 8q24.12 | ||
| Entrez ID: 5168 | HGNC ID: HGNC:3357 | Ensembl Gene: ENSG00000136960 | OMIM ID: 601060 |
| Drug and gene relationship at DGIdb | |||
Expression of ENPP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENPP2 | 5168 | 209392_at | -0.5597 | 0.6099 | |
| GSE20347 | ENPP2 | 5168 | 209392_at | 0.1040 | 0.7682 | |
| GSE23400 | ENPP2 | 5168 | 210839_s_at | 0.0949 | 0.3388 | |
| GSE26886 | ENPP2 | 5168 | 209392_at | 0.5080 | 0.5718 | |
| GSE29001 | ENPP2 | 5168 | 209392_at | 0.3593 | 0.6571 | |
| GSE38129 | ENPP2 | 5168 | 209392_at | -0.2979 | 0.5194 | |
| GSE45670 | ENPP2 | 5168 | 209392_at | -1.2648 | 0.0049 | |
| GSE53622 | ENPP2 | 5168 | 38054 | 0.1676 | 0.2497 | |
| GSE53624 | ENPP2 | 5168 | 38054 | -0.0380 | 0.8326 | |
| GSE63941 | ENPP2 | 5168 | 210839_s_at | -0.5269 | 0.4569 | |
| GSE77861 | ENPP2 | 5168 | 209392_at | 0.0283 | 0.9576 | |
| GSE97050 | ENPP2 | 5168 | A_23_P94338 | 0.8876 | 0.1582 | |
| SRP007169 | ENPP2 | 5168 | RNAseq | 1.7776 | 0.0004 | |
| SRP008496 | ENPP2 | 5168 | RNAseq | 2.0106 | 0.0000 | |
| SRP064894 | ENPP2 | 5168 | RNAseq | 0.6129 | 0.0399 | |
| SRP133303 | ENPP2 | 5168 | RNAseq | -0.0839 | 0.7873 | |
| SRP159526 | ENPP2 | 5168 | RNAseq | 0.6157 | 0.2115 | |
| SRP193095 | ENPP2 | 5168 | RNAseq | -0.4297 | 0.2002 | |
| SRP219564 | ENPP2 | 5168 | RNAseq | 0.5929 | 0.3942 | |
| TCGA | ENPP2 | 5168 | RNAseq | -0.5884 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by ENPP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENPP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENPP2 | 5168 | 19 | 1 | 10 | |
| GSE20123 | ENPP2 | 5168 | 20 | 1 | 9 | |
| GSE43470 | ENPP2 | 5168 | 23 | 0 | 20 | |
| GSE46452 | ENPP2 | 5168 | 26 | 0 | 33 | |
| GSE47630 | ENPP2 | 5168 | 24 | 0 | 16 | |
| GSE54993 | ENPP2 | 5168 | 0 | 20 | 50 | |
| GSE54994 | ENPP2 | 5168 | 37 | 1 | 15 | |
| GSE60625 | ENPP2 | 5168 | 0 | 4 | 7 | |
| GSE74703 | ENPP2 | 5168 | 19 | 0 | 17 | |
| GSE74704 | ENPP2 | 5168 | 13 | 1 | 6 | |
| TCGA | ENPP2 | 5168 | 67 | 2 | 27 |
Total number of gains: 248; Total number of losses: 30; Total Number of normals: 210.
Somatic mutations of ENPP2:
Generating mutation plots.
Highly correlated genes for ENPP2:
Showing top 20/603 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENPP2 | MPEG1 | 0.711179 | 6 | 0 | 4 |
| ENPP2 | EFHD1 | 0.710408 | 3 | 0 | 3 |
| ENPP2 | TMEM71 | 0.704546 | 3 | 0 | 3 |
| ENPP2 | GZMK | 0.699612 | 5 | 0 | 5 |
| ENPP2 | FCGR2B | 0.694692 | 7 | 0 | 6 |
| ENPP2 | ARHGAP15 | 0.690992 | 3 | 0 | 3 |
| ENPP2 | C3 | 0.690716 | 7 | 0 | 7 |
| ENPP2 | C1orf162 | 0.690542 | 7 | 0 | 6 |
| ENPP2 | TM4SF18 | 0.689684 | 3 | 0 | 3 |
| ENPP2 | CDH5 | 0.681264 | 7 | 0 | 6 |
| ENPP2 | PIK3R6 | 0.680624 | 3 | 0 | 3 |
| ENPP2 | BST1 | 0.67863 | 3 | 0 | 3 |
| ENPP2 | MRGPRF | 0.675477 | 3 | 0 | 3 |
| ENPP2 | GJA4 | 0.674293 | 5 | 0 | 4 |
| ENPP2 | NT5E | 0.669899 | 3 | 0 | 3 |
| ENPP2 | ARHGAP29 | 0.667099 | 5 | 0 | 5 |
| ENPP2 | SHE | 0.663969 | 5 | 0 | 4 |
| ENPP2 | BHLHE22 | 0.663235 | 4 | 0 | 3 |
| ENPP2 | SRGN | 0.66188 | 11 | 0 | 9 |
| ENPP2 | SERPINF1 | 0.659012 | 10 | 0 | 7 |
For details and further investigation, click here
