| Full name: ferrochelatase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.31 | ||
| Entrez ID: 2235 | HGNC ID: HGNC:3647 | Ensembl Gene: ENSG00000066926 | OMIM ID: 612386 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FECH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FECH | 2235 | 203116_s_at | 0.0022 | 0.9982 | |
| GSE20347 | FECH | 2235 | 203116_s_at | 0.1686 | 0.4009 | |
| GSE23400 | FECH | 2235 | 203116_s_at | 0.1059 | 0.2212 | |
| GSE26886 | FECH | 2235 | 203116_s_at | -0.7444 | 0.0131 | |
| GSE29001 | FECH | 2235 | 203116_s_at | -0.1171 | 0.6749 | |
| GSE38129 | FECH | 2235 | 203116_s_at | 0.3018 | 0.0560 | |
| GSE45670 | FECH | 2235 | 203116_s_at | -0.0029 | 0.9893 | |
| GSE53622 | FECH | 2235 | 50710 | -0.4287 | 0.0038 | |
| GSE53624 | FECH | 2235 | 50710 | -0.1915 | 0.0601 | |
| GSE63941 | FECH | 2235 | 203116_s_at | -0.4257 | 0.5390 | |
| GSE77861 | FECH | 2235 | 203116_s_at | 0.1576 | 0.6681 | |
| GSE97050 | FECH | 2235 | A_32_P151933 | -0.5978 | 0.1403 | |
| SRP007169 | FECH | 2235 | RNAseq | -0.2496 | 0.5667 | |
| SRP008496 | FECH | 2235 | RNAseq | 0.1173 | 0.7560 | |
| SRP064894 | FECH | 2235 | RNAseq | -0.0742 | 0.6404 | |
| SRP133303 | FECH | 2235 | RNAseq | -0.2966 | 0.0275 | |
| SRP159526 | FECH | 2235 | RNAseq | 0.7183 | 0.1471 | |
| SRP193095 | FECH | 2235 | RNAseq | 0.1060 | 0.2839 | |
| SRP219564 | FECH | 2235 | RNAseq | -0.3388 | 0.4063 | |
| TCGA | FECH | 2235 | RNAseq | -0.0065 | 0.9395 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FECH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FECH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FECH | 2235 | 2 | 9 | 19 | |
| GSE20123 | FECH | 2235 | 2 | 9 | 19 | |
| GSE43470 | FECH | 2235 | 0 | 5 | 38 | |
| GSE46452 | FECH | 2235 | 1 | 26 | 32 | |
| GSE47630 | FECH | 2235 | 5 | 20 | 15 | |
| GSE54993 | FECH | 2235 | 10 | 0 | 60 | |
| GSE54994 | FECH | 2235 | 0 | 18 | 35 | |
| GSE60625 | FECH | 2235 | 0 | 4 | 7 | |
| GSE74703 | FECH | 2235 | 0 | 5 | 31 | |
| GSE74704 | FECH | 2235 | 2 | 6 | 12 | |
| TCGA | FECH | 2235 | 9 | 43 | 44 |
Total number of gains: 31; Total number of losses: 145; Total Number of normals: 312.
Somatic mutations of FECH:
Generating mutation plots.
Highly correlated genes for FECH:
Showing top 20/157 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FECH | AMOTL1 | 0.728762 | 3 | 0 | 3 |
| FECH | LGALSL | 0.707823 | 3 | 0 | 3 |
| FECH | SNX12 | 0.697469 | 3 | 0 | 3 |
| FECH | SLTM | 0.694541 | 3 | 0 | 3 |
| FECH | IREB2 | 0.686198 | 3 | 0 | 3 |
| FECH | ENDOD1 | 0.685543 | 3 | 0 | 3 |
| FECH | ALAS1 | 0.685117 | 3 | 0 | 3 |
| FECH | SNX7 | 0.684404 | 3 | 0 | 3 |
| FECH | CNOT1 | 0.676426 | 3 | 0 | 3 |
| FECH | NSMAF | 0.67593 | 4 | 0 | 3 |
| FECH | UBP1 | 0.674696 | 4 | 0 | 3 |
| FECH | RHOA | 0.673837 | 3 | 0 | 3 |
| FECH | CAPZA2 | 0.672988 | 3 | 0 | 3 |
| FECH | WDR7 | 0.669754 | 8 | 0 | 6 |
| FECH | ZCCHC14 | 0.669009 | 3 | 0 | 3 |
| FECH | SEMA6A | 0.668503 | 4 | 0 | 3 |
| FECH | TIMM21 | 0.660458 | 4 | 0 | 4 |
| FECH | SCAPER | 0.652097 | 4 | 0 | 3 |
| FECH | TMEM126A | 0.650929 | 3 | 0 | 3 |
| FECH | TCHP | 0.637343 | 4 | 0 | 3 |
For details and further investigation, click here
