| Full name: FYVE, RhoGEF and PH domain containing 2 | Alias Symbol: ZFYVE4 | ||
| Type: protein-coding gene | Cytoband: 6p21.2 | ||
| Entrez ID: 221472 | HGNC ID: HGNC:3664 | Ensembl Gene: ENSG00000146192 | OMIM ID: 605091 |
| Drug and gene relationship at DGIdb | |||
Expression of FGD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGD2 | 221472 | 1553906_s_at | -0.4146 | 0.5150 | |
| GSE20347 | FGD2 | 221472 | 215602_at | 0.0978 | 0.3328 | |
| GSE23400 | FGD2 | 221472 | 215602_at | 0.0021 | 0.9516 | |
| GSE26886 | FGD2 | 221472 | 1553906_s_at | -0.5934 | 0.0080 | |
| GSE29001 | FGD2 | 221472 | 215602_at | 0.1598 | 0.1890 | |
| GSE38129 | FGD2 | 221472 | 215602_at | 0.0361 | 0.6716 | |
| GSE45670 | FGD2 | 221472 | 1553906_s_at | -0.2246 | 0.4295 | |
| GSE53622 | FGD2 | 221472 | 27293 | -0.1714 | 0.0121 | |
| GSE53624 | FGD2 | 221472 | 27293 | -0.0668 | 0.2854 | |
| GSE63941 | FGD2 | 221472 | 1553906_s_at | 0.1915 | 0.4065 | |
| GSE77861 | FGD2 | 221472 | 1553906_s_at | -0.3811 | 0.0136 | |
| GSE97050 | FGD2 | 221472 | A_24_P140788 | 0.3810 | 0.2330 | |
| SRP007169 | FGD2 | 221472 | RNAseq | -2.7960 | 0.0001 | |
| SRP064894 | FGD2 | 221472 | RNAseq | -0.0156 | 0.9590 | |
| SRP133303 | FGD2 | 221472 | RNAseq | -0.5205 | 0.0162 | |
| SRP159526 | FGD2 | 221472 | RNAseq | -1.4854 | 0.0217 | |
| SRP193095 | FGD2 | 221472 | RNAseq | -0.7827 | 0.0000 | |
| SRP219564 | FGD2 | 221472 | RNAseq | 0.1632 | 0.7158 | |
| TCGA | FGD2 | 221472 | RNAseq | -0.0078 | 0.9608 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FGD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGD2 | 221472 | 6 | 0 | 24 | |
| GSE20123 | FGD2 | 221472 | 6 | 0 | 24 | |
| GSE43470 | FGD2 | 221472 | 5 | 1 | 37 | |
| GSE46452 | FGD2 | 221472 | 2 | 9 | 48 | |
| GSE47630 | FGD2 | 221472 | 8 | 4 | 28 | |
| GSE54993 | FGD2 | 221472 | 3 | 1 | 66 | |
| GSE54994 | FGD2 | 221472 | 10 | 5 | 38 | |
| GSE60625 | FGD2 | 221472 | 1 | 0 | 10 | |
| GSE74703 | FGD2 | 221472 | 5 | 0 | 31 | |
| GSE74704 | FGD2 | 221472 | 3 | 0 | 17 | |
| TCGA | FGD2 | 221472 | 16 | 14 | 66 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of FGD2:
Generating mutation plots.
Highly correlated genes for FGD2:
Showing top 20/218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGD2 | TGM1 | 0.65789 | 3 | 0 | 3 |
| FGD2 | DUOXA2 | 0.651193 | 4 | 0 | 4 |
| FGD2 | RSPH9 | 0.650849 | 3 | 0 | 3 |
| FGD2 | ATP10B | 0.633692 | 5 | 0 | 4 |
| FGD2 | LIPE-AS1 | 0.632523 | 3 | 0 | 3 |
| FGD2 | MAPKAPK3 | 0.627861 | 3 | 0 | 3 |
| FGD2 | COL23A1 | 0.627154 | 3 | 0 | 3 |
| FGD2 | C22orf31 | 0.625547 | 4 | 0 | 3 |
| FGD2 | CYP4B1 | 0.622637 | 4 | 0 | 3 |
| FGD2 | KLB | 0.621288 | 4 | 0 | 3 |
| FGD2 | ACOX3 | 0.610173 | 4 | 0 | 3 |
| FGD2 | TIFA | 0.608461 | 4 | 0 | 4 |
| FGD2 | PROM2 | 0.608201 | 3 | 0 | 3 |
| FGD2 | MCF2 | 0.607459 | 3 | 0 | 3 |
| FGD2 | KLK4 | 0.607279 | 4 | 0 | 3 |
| FGD2 | SUSD2 | 0.605635 | 3 | 0 | 3 |
| FGD2 | S100A16 | 0.605422 | 3 | 0 | 3 |
| FGD2 | NLRP12 | 0.605259 | 3 | 0 | 3 |
| FGD2 | FUT6 | 0.602942 | 5 | 0 | 4 |
| FGD2 | CAPN1 | 0.601 | 4 | 0 | 4 |
For details and further investigation, click here
