| Full name: vascular cell adhesion molecule 1 | Alias Symbol: CD106 | ||
| Type: protein-coding gene | Cytoband: 1p21.2 | ||
| Entrez ID: 7412 | HGNC ID: HGNC:12663 | Ensembl Gene: ENSG00000162692 | OMIM ID: 192225 |
| Drug and gene relationship at DGIdb | |||
VCAM1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of VCAM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VCAM1 | 7412 | 203868_s_at | 0.1657 | 0.9177 | |
| GSE20347 | VCAM1 | 7412 | 203868_s_at | 1.5069 | 0.0000 | |
| GSE23400 | VCAM1 | 7412 | 203868_s_at | 0.7605 | 0.0001 | |
| GSE26886 | VCAM1 | 7412 | 203868_s_at | 1.0620 | 0.2123 | |
| GSE29001 | VCAM1 | 7412 | 203868_s_at | 1.3575 | 0.0223 | |
| GSE38129 | VCAM1 | 7412 | 203868_s_at | 1.2092 | 0.0013 | |
| GSE45670 | VCAM1 | 7412 | 203868_s_at | -1.0096 | 0.0482 | |
| GSE63941 | VCAM1 | 7412 | 203868_s_at | -8.0018 | 0.0000 | |
| GSE77861 | VCAM1 | 7412 | 203868_s_at | 0.6435 | 0.0089 | |
| GSE97050 | VCAM1 | 7412 | A_23_P34345 | 0.6801 | 0.2447 | |
| SRP007169 | VCAM1 | 7412 | RNAseq | 2.9731 | 0.0000 | |
| SRP008496 | VCAM1 | 7412 | RNAseq | 3.3481 | 0.0000 | |
| SRP064894 | VCAM1 | 7412 | RNAseq | 1.0160 | 0.0111 | |
| SRP133303 | VCAM1 | 7412 | RNAseq | 0.6794 | 0.0147 | |
| SRP159526 | VCAM1 | 7412 | RNAseq | 0.8602 | 0.1470 | |
| SRP193095 | VCAM1 | 7412 | RNAseq | 1.7338 | 0.0000 | |
| SRP219564 | VCAM1 | 7412 | RNAseq | 1.6349 | 0.0608 | |
| TCGA | VCAM1 | 7412 | RNAseq | 0.3022 | 0.0649 |
Upregulated datasets: 7; Downregulated datasets: 2.
Survival by VCAM1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of VCAM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VCAM1 | 7412 | 0 | 10 | 20 | |
| GSE20123 | VCAM1 | 7412 | 0 | 10 | 20 | |
| GSE43470 | VCAM1 | 7412 | 2 | 6 | 35 | |
| GSE46452 | VCAM1 | 7412 | 1 | 1 | 57 | |
| GSE47630 | VCAM1 | 7412 | 9 | 5 | 26 | |
| GSE54993 | VCAM1 | 7412 | 0 | 1 | 69 | |
| GSE54994 | VCAM1 | 7412 | 6 | 3 | 44 | |
| GSE60625 | VCAM1 | 7412 | 0 | 0 | 11 | |
| GSE74703 | VCAM1 | 7412 | 1 | 5 | 30 | |
| GSE74704 | VCAM1 | 7412 | 0 | 6 | 14 | |
| TCGA | VCAM1 | 7412 | 8 | 25 | 63 |
Total number of gains: 27; Total number of losses: 72; Total Number of normals: 389.
Somatic mutations of VCAM1:
Generating mutation plots.
Highly correlated genes for VCAM1:
Showing top 20/863 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VCAM1 | DNM3OS | 0.814878 | 3 | 0 | 3 |
| VCAM1 | TMEM176A | 0.757651 | 11 | 0 | 11 |
| VCAM1 | PDCD1LG2 | 0.755553 | 3 | 0 | 3 |
| VCAM1 | FBN1 | 0.740164 | 10 | 0 | 10 |
| VCAM1 | PRRX1 | 0.740159 | 10 | 0 | 9 |
| VCAM1 | VCAN | 0.725042 | 11 | 0 | 10 |
| VCAM1 | C1S | 0.722354 | 11 | 0 | 11 |
| VCAM1 | SHC3 | 0.720118 | 3 | 0 | 3 |
| VCAM1 | COL6A3 | 0.718354 | 11 | 0 | 11 |
| VCAM1 | SGIP1 | 0.718168 | 4 | 0 | 4 |
| VCAM1 | RASGRF2 | 0.714225 | 3 | 0 | 3 |
| VCAM1 | PLXNC1 | 0.712779 | 8 | 0 | 8 |
| VCAM1 | CNRIP1 | 0.712274 | 6 | 0 | 5 |
| VCAM1 | MYO1B | 0.707192 | 3 | 0 | 3 |
| VCAM1 | CHN1 | 0.705397 | 11 | 0 | 10 |
| VCAM1 | SPARC | 0.704787 | 10 | 0 | 9 |
| VCAM1 | DPYSL2 | 0.703984 | 10 | 0 | 10 |
| VCAM1 | PTGFR | 0.703383 | 3 | 0 | 3 |
| VCAM1 | CTSK | 0.70184 | 11 | 0 | 10 |
| VCAM1 | C1R | 0.699227 | 10 | 0 | 10 |
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