IPO8

 

Full name: importin 8 Alias Symbol: IMP8
Type: protein-coding gene Cytoband: 12p11.21
Entrez ID: 10526 HGNC ID: HGNC:9853 Ensembl Gene: ENSG00000133704 OMIM ID: 605600
Drug and gene relationship at DGIdb

 

Expression of IPO8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IPO8 10526 225528_at -0.2736 0.5104
GSE20347 IPO8 10526 205701_at 0.1567 0.1132
GSE23400 IPO8 10526 205701_at 0.0669 0.0465
GSE26886 IPO8 10526 225528_at 0.2351 0.3227
GSE29001 IPO8 10526 205701_at -0.0161 0.9297
GSE38129 IPO8 10526 205701_at 0.0246 0.8586
GSE45670 IPO8 10526 225528_at -0.0923 0.4629
GSE53622 IPO8 10526 114969 -0.4341 0.0000
GSE53624 IPO8 10526 114969 -0.2141 0.0007
GSE63941 IPO8 10526 225528_at -0.1942 0.7103
GSE77861 IPO8 10526 225528_at -0.1895 0.4345
GSE97050 IPO8 10526 A_33_P3369286 -0.4174 0.1415
SRP007169 IPO8 10526 RNAseq 0.7275 0.0639
SRP008496 IPO8 10526 RNAseq 0.7935 0.0062
SRP064894 IPO8 10526 RNAseq -0.0709 0.6742
SRP133303 IPO8 10526 RNAseq -0.0658 0.6875
SRP159526 IPO8 10526 RNAseq -0.4069 0.0049
SRP193095 IPO8 10526 RNAseq -0.3448 0.0005
SRP219564 IPO8 10526 RNAseq -0.2338 0.5246
TCGA IPO8 10526 RNAseq -0.1054 0.0182

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IPO8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IPO8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IPO8 10526 12 0 18
GSE20123 IPO8 10526 12 0 18
GSE43470 IPO8 10526 8 4 31
GSE46452 IPO8 10526 10 1 48
GSE47630 IPO8 10526 12 1 27
GSE54993 IPO8 10526 0 9 61
GSE54994 IPO8 10526 8 2 43
GSE60625 IPO8 10526 0 1 10
GSE74703 IPO8 10526 7 3 26
GSE74704 IPO8 10526 6 0 14
TCGA IPO8 10526 41 6 49

Total number of gains: 116; Total number of losses: 27; Total Number of normals: 345.  

 

Somatic mutations of IPO8:

 

Generating mutation plots.

 

Highly correlated genes for IPO8:

 

Showing top 20/284 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IPO8KAT50.776343303
IPO8OTUD7B0.771517303
IPO8CTDSPL0.75317404
IPO8ANKRA20.753107404
IPO8FBXO420.744695303
IPO8FGFR20.735642303
IPO8N4BP2L20.723586404
IPO8IGIP0.723422303
IPO8TXNDC160.721334303
IPO8MSRB30.719059303
IPO8ZFYVE10.716018303
IPO8MLLT30.706771303
IPO8ARGLU10.706325303
IPO8RASSF30.705934303
IPO8AFF30.704486303
IPO8FBXL140.702334404
IPO8HDAC60.70184303
IPO8SLITRK30.701212303
IPO8ZNF6100.70065303
IPO8PELI20.700235303

For details and further investigation, click here