| Full name: dual specificity phosphatase 2 | Alias Symbol: PAC-1 | ||
| Type: protein-coding gene | Cytoband: 2q11.2 | ||
| Entrez ID: 1844 | HGNC ID: HGNC:3068 | Ensembl Gene: ENSG00000158050 | OMIM ID: 603068 |
| Drug and gene relationship at DGIdb | |||
DUSP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUSP2 | 1844 | 204794_at | 0.7531 | 0.3871 | |
| GSE20347 | DUSP2 | 1844 | 204794_at | 0.6360 | 0.0009 | |
| GSE23400 | DUSP2 | 1844 | 204794_at | 0.1616 | 0.0331 | |
| GSE26886 | DUSP2 | 1844 | 204794_at | 0.9329 | 0.0532 | |
| GSE29001 | DUSP2 | 1844 | 204794_at | 0.8538 | 0.0353 | |
| GSE38129 | DUSP2 | 1844 | 204794_at | 0.5908 | 0.0032 | |
| GSE45670 | DUSP2 | 1844 | 204794_at | 0.3511 | 0.1191 | |
| GSE53622 | DUSP2 | 1844 | 108550 | -1.5472 | 0.0000 | |
| GSE53624 | DUSP2 | 1844 | 108550 | -1.7015 | 0.0000 | |
| GSE63941 | DUSP2 | 1844 | 204794_at | 0.7707 | 0.2929 | |
| GSE77861 | DUSP2 | 1844 | 204794_at | 0.1964 | 0.3088 | |
| GSE97050 | DUSP2 | 1844 | A_24_P37409 | -0.4523 | 0.5154 | |
| SRP007169 | DUSP2 | 1844 | RNAseq | 0.2865 | 0.5977 | |
| SRP008496 | DUSP2 | 1844 | RNAseq | 0.2572 | 0.5351 | |
| SRP064894 | DUSP2 | 1844 | RNAseq | 1.3148 | 0.0011 | |
| SRP133303 | DUSP2 | 1844 | RNAseq | 0.5329 | 0.1319 | |
| SRP159526 | DUSP2 | 1844 | RNAseq | 0.6172 | 0.2691 | |
| SRP193095 | DUSP2 | 1844 | RNAseq | 1.2188 | 0.0002 | |
| SRP219564 | DUSP2 | 1844 | RNAseq | 0.8220 | 0.2058 | |
| TCGA | DUSP2 | 1844 | RNAseq | 0.4844 | 0.0029 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by DUSP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP2 | 1844 | 6 | 2 | 22 | |
| GSE20123 | DUSP2 | 1844 | 6 | 2 | 22 | |
| GSE43470 | DUSP2 | 1844 | 2 | 3 | 38 | |
| GSE46452 | DUSP2 | 1844 | 2 | 3 | 54 | |
| GSE47630 | DUSP2 | 1844 | 7 | 0 | 33 | |
| GSE54993 | DUSP2 | 1844 | 0 | 6 | 64 | |
| GSE54994 | DUSP2 | 1844 | 11 | 0 | 42 | |
| GSE60625 | DUSP2 | 1844 | 0 | 3 | 8 | |
| GSE74703 | DUSP2 | 1844 | 2 | 2 | 32 | |
| GSE74704 | DUSP2 | 1844 | 4 | 1 | 15 | |
| TCGA | DUSP2 | 1844 | 35 | 3 | 58 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of DUSP2:
Generating mutation plots.
Highly correlated genes for DUSP2:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP2 | DUSP1 | 0.813199 | 4 | 0 | 4 |
| DUSP2 | JUND | 0.679505 | 4 | 0 | 3 |
| DUSP2 | ELN | 0.672175 | 3 | 0 | 3 |
| DUSP2 | FOSB | 0.671941 | 5 | 0 | 5 |
| DUSP2 | RASSF3 | 0.666288 | 3 | 0 | 3 |
| DUSP2 | PIM3 | 0.661544 | 4 | 0 | 4 |
| DUSP2 | FOS | 0.648828 | 5 | 0 | 4 |
| DUSP2 | FGF5 | 0.647623 | 3 | 0 | 3 |
| DUSP2 | MIDN | 0.642925 | 3 | 0 | 3 |
| DUSP2 | MORN3 | 0.64037 | 3 | 0 | 3 |
| DUSP2 | PLAC9 | 0.638798 | 3 | 0 | 3 |
| DUSP2 | ARID5A | 0.634497 | 5 | 0 | 5 |
| DUSP2 | PCP4 | 0.633257 | 3 | 0 | 3 |
| DUSP2 | RBFOX3 | 0.630367 | 3 | 0 | 3 |
| DUSP2 | CCDC50 | 0.628224 | 3 | 0 | 3 |
| DUSP2 | C19orf57 | 0.620349 | 3 | 0 | 3 |
| DUSP2 | SFI1 | 0.599242 | 4 | 0 | 3 |
| DUSP2 | CDX1 | 0.598918 | 4 | 0 | 3 |
| DUSP2 | SRD5A3-AS1 | 0.597534 | 3 | 0 | 3 |
| DUSP2 | USP2 | 0.596362 | 3 | 0 | 3 |
For details and further investigation, click here
