FOS

 

Full name: Fos proto-oncogene, AP-1 transcription factor subunit Alias Symbol: c-fos|AP-1
Type: protein-coding gene Cytoband: 14q24.3
Entrez ID: 2353 HGNC ID: HGNC:3796 Ensembl Gene: ENSG00000170345 OMIM ID: 164810
Drug and gene relationship at DGIdb

 

FOS involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04024cAMP signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04713Circadian entrainment
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04921Oxytocin signaling pathway
hsa05031Amphetamine addiction
hsa05132Salmonella infection
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05168Herpes simplex infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05231Choline metabolism in cancer

 

Expression of FOS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FOS 2353 209189_at -1.1631 0.3898
GSE20347 FOS 2353 209189_at -1.9326 0.0007
GSE23400 FOS 2353 209189_at -0.8103 0.0002
GSE26886 FOS 2353 209189_at 1.8555 0.0045
GSE29001 FOS 2353 209189_at -2.0930 0.0001
GSE38129 FOS 2353 209189_at -2.0240 0.0000
GSE45670 FOS 2353 209189_at -1.8586 0.0064
GSE53622 FOS 2353 66626 -1.4682 0.0000
GSE53624 FOS 2353 66626 -1.5251 0.0000
GSE63941 FOS 2353 209189_at 1.4034 0.1910
GSE77861 FOS 2353 209189_at 0.1759 0.8716
GSE97050 FOS 2353 A_23_P106194 -0.4284 0.5703
SRP007169 FOS 2353 RNAseq -3.3968 0.0000
SRP008496 FOS 2353 RNAseq -2.5389 0.0000
SRP064894 FOS 2353 RNAseq -0.8066 0.0163
SRP133303 FOS 2353 RNAseq -0.7258 0.2029
SRP159526 FOS 2353 RNAseq 0.0470 0.9456
SRP193095 FOS 2353 RNAseq 0.5875 0.1977
SRP219564 FOS 2353 RNAseq 0.0459 0.9377
TCGA FOS 2353 RNAseq -0.1825 0.0904

Upregulated datasets: 1; Downregulated datasets: 8.  

 

Survival by FOS expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FOS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FOS 2353 8 3 19
GSE20123 FOS 2353 8 3 19
GSE43470 FOS 2353 8 3 32
GSE46452 FOS 2353 16 3 40
GSE47630 FOS 2353 11 8 21
GSE54993 FOS 2353 3 8 59
GSE54994 FOS 2353 19 4 30
GSE60625 FOS 2353 0 2 9
GSE74703 FOS 2353 7 3 26
GSE74704 FOS 2353 3 3 14
TCGA FOS 2353 33 16 47

Total number of gains: 116; Total number of losses: 56; Total Number of normals: 316.  

 

Somatic mutations of FOS:

 

Generating mutation plots.

 

Highly correlated genes for FOS:

 

Showing top 20/93 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FOSDUSP10.80515412012
FOSJUN0.75921212012
FOSEGR10.73432813011
FOSFOSB0.71608213013
FOSJUNB0.67514412010
FOSKLF100.658082303
FOSPROX10.653234303
FOSTMEM180.648973303
FOSDUSP20.648828504
FOSDNAJC180.64389404
FOSTWF20.639431403
FOSNELL10.639185303
FOSTOB10.63580310010
FOSNPFFR10.635335303
FOSDYSF0.634607303
FOSC9orf470.631062303
FOSIER20.6226371008
FOSSLC25A250.622621504
FOSCSRNP10.622563505
FOSHSD17B120.621561303

For details and further investigation, click here