| Full name: lysine methyltransferase 2E | Alias Symbol: HDCMC04P | ||
| Type: protein-coding gene | Cytoband: 7q22.3 | ||
| Entrez ID: 55904 | HGNC ID: HGNC:18541 | Ensembl Gene: ENSG00000005483 | OMIM ID: 608444 |
| Drug and gene relationship at DGIdb | |||
Expression of KMT2E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KMT2E | 55904 | 223190_s_at | -0.2127 | 0.7125 | |
| GSE26886 | KMT2E | 55904 | 226100_at | 0.5271 | 0.0319 | |
| GSE45670 | KMT2E | 55904 | 223190_s_at | -0.1597 | 0.3946 | |
| GSE53622 | KMT2E | 55904 | 16348 | 0.0667 | 0.3592 | |
| GSE53624 | KMT2E | 55904 | 83374 | -0.0698 | 0.1145 | |
| GSE63941 | KMT2E | 55904 | 223190_s_at | -0.3694 | 0.3532 | |
| GSE77861 | KMT2E | 55904 | 223190_s_at | 0.5166 | 0.0233 | |
| SRP007169 | KMT2E | 55904 | RNAseq | 0.4086 | 0.2346 | |
| SRP008496 | KMT2E | 55904 | RNAseq | 0.7002 | 0.0062 | |
| SRP064894 | KMT2E | 55904 | RNAseq | -0.3456 | 0.1342 | |
| SRP133303 | KMT2E | 55904 | RNAseq | -0.0976 | 0.4126 | |
| SRP159526 | KMT2E | 55904 | RNAseq | -0.3975 | 0.0357 | |
| SRP193095 | KMT2E | 55904 | RNAseq | 0.1473 | 0.2295 | |
| SRP219564 | KMT2E | 55904 | RNAseq | -0.1317 | 0.6665 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KMT2E expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of KMT2E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KMT2E | 55904 | 13 | 0 | 17 | |
| GSE20123 | KMT2E | 55904 | 13 | 0 | 17 | |
| GSE43470 | KMT2E | 55904 | 7 | 1 | 35 | |
| GSE46452 | KMT2E | 55904 | 10 | 1 | 48 | |
| GSE47630 | KMT2E | 55904 | 7 | 3 | 30 | |
| GSE54993 | KMT2E | 55904 | 2 | 10 | 58 | |
| GSE54994 | KMT2E | 55904 | 15 | 3 | 35 | |
| GSE60625 | KMT2E | 55904 | 0 | 0 | 11 | |
| GSE74703 | KMT2E | 55904 | 7 | 1 | 28 | |
| GSE74704 | KMT2E | 55904 | 8 | 0 | 12 | |
| TCGA | KMT2E | 55904 | 53 | 9 | 34 |
Total number of gains: 135; Total number of losses: 28; Total Number of normals: 325.
Somatic mutations of KMT2E:
Generating mutation plots.
Highly correlated genes for KMT2E:
Showing top 20/23 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KMT2E | SP100 | 0.697227 | 3 | 0 | 3 |
| KMT2E | BBS10 | 0.659702 | 3 | 0 | 3 |
| KMT2E | FOXO1 | 0.659668 | 3 | 0 | 3 |
| KMT2E | RNF19A | 0.651295 | 4 | 0 | 3 |
| KMT2E | UTP23 | 0.632789 | 3 | 0 | 3 |
| KMT2E | MDM4 | 0.632625 | 3 | 0 | 3 |
| KMT2E | DDX60L | 0.617634 | 3 | 0 | 3 |
| KMT2E | TRIM52-AS1 | 0.602008 | 3 | 0 | 3 |
| KMT2E | RBPJ | 0.582484 | 4 | 0 | 3 |
| KMT2E | DDX42 | 0.578995 | 4 | 0 | 3 |
| KMT2E | BBS1 | 0.578319 | 3 | 0 | 3 |
| KMT2E | TAF1 | 0.573268 | 4 | 0 | 3 |
| KMT2E | LAMC1 | 0.572978 | 4 | 0 | 3 |
| KMT2E | LINC01004 | 0.563685 | 4 | 0 | 3 |
| KMT2E | IFT22 | 0.551682 | 3 | 0 | 3 |
| KMT2E | BPTF | 0.550285 | 5 | 0 | 3 |
| KMT2E | SRSF11 | 0.547159 | 3 | 0 | 3 |
| KMT2E | GPC4 | 0.54213 | 4 | 0 | 3 |
| KMT2E | CCNB1IP1 | 0.539369 | 4 | 0 | 3 |
| KMT2E | INPP5F | 0.51414 | 4 | 0 | 3 |
For details and further investigation, click here
