| Full name: schlafen family member 5 | Alias Symbol: MGC19764 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 162394 | HGNC ID: HGNC:28286 | Ensembl Gene: ENSG00000166750 | OMIM ID: 614952 |
| Drug and gene relationship at DGIdb | |||
Expression of SLFN5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLFN5 | 162394 | 238430_x_at | -0.0199 | 0.9879 | |
| GSE26886 | SLFN5 | 162394 | 238430_x_at | 1.1660 | 0.0023 | |
| GSE45670 | SLFN5 | 162394 | 238430_x_at | 0.4042 | 0.1553 | |
| GSE63941 | SLFN5 | 162394 | 238430_x_at | -2.6265 | 0.0057 | |
| GSE77861 | SLFN5 | 162394 | 226725_at | 0.6318 | 0.0296 | |
| GSE97050 | SLFN5 | 162394 | A_33_P3209522 | 0.1862 | 0.3765 | |
| SRP007169 | SLFN5 | 162394 | RNAseq | 2.8483 | 0.0000 | |
| SRP008496 | SLFN5 | 162394 | RNAseq | 2.3763 | 0.0000 | |
| SRP064894 | SLFN5 | 162394 | RNAseq | 0.5980 | 0.0226 | |
| SRP133303 | SLFN5 | 162394 | RNAseq | 0.4984 | 0.0197 | |
| SRP159526 | SLFN5 | 162394 | RNAseq | 0.2072 | 0.6716 | |
| SRP193095 | SLFN5 | 162394 | RNAseq | 0.8846 | 0.0000 | |
| SRP219564 | SLFN5 | 162394 | RNAseq | 0.9585 | 0.1573 | |
| TCGA | SLFN5 | 162394 | RNAseq | 0.2634 | 0.0060 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by SLFN5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SLFN5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLFN5 | 162394 | 5 | 1 | 24 | |
| GSE20123 | SLFN5 | 162394 | 5 | 1 | 24 | |
| GSE43470 | SLFN5 | 162394 | 1 | 2 | 40 | |
| GSE46452 | SLFN5 | 162394 | 34 | 0 | 25 | |
| GSE47630 | SLFN5 | 162394 | 7 | 1 | 32 | |
| GSE54993 | SLFN5 | 162394 | 3 | 3 | 64 | |
| GSE54994 | SLFN5 | 162394 | 8 | 6 | 39 | |
| GSE60625 | SLFN5 | 162394 | 4 | 0 | 7 | |
| GSE74703 | SLFN5 | 162394 | 1 | 1 | 34 | |
| GSE74704 | SLFN5 | 162394 | 3 | 1 | 16 | |
| TCGA | SLFN5 | 162394 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of SLFN5:
Generating mutation plots.
Highly correlated genes for SLFN5:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLFN5 | PLAU | 0.696817 | 3 | 0 | 3 |
| SLFN5 | LUM | 0.695425 | 4 | 0 | 4 |
| SLFN5 | PTPRK | 0.691691 | 5 | 0 | 5 |
| SLFN5 | UGGT1 | 0.687774 | 3 | 0 | 3 |
| SLFN5 | FOXO1 | 0.682631 | 3 | 0 | 3 |
| SLFN5 | ACLY | 0.670873 | 3 | 0 | 3 |
| SLFN5 | SOX4 | 0.669486 | 4 | 0 | 4 |
| SLFN5 | RASEF | 0.666567 | 3 | 0 | 3 |
| SLFN5 | LPA | 0.666134 | 3 | 0 | 3 |
| SLFN5 | ALKBH6 | 0.658812 | 4 | 0 | 3 |
| SLFN5 | GRAMD1A | 0.657912 | 3 | 0 | 3 |
| SLFN5 | LPCAT1 | 0.657888 | 3 | 0 | 3 |
| SLFN5 | LOXL1 | 0.65336 | 3 | 0 | 3 |
| SLFN5 | TNFRSF10B | 0.651239 | 3 | 0 | 3 |
| SLFN5 | RIMKLB | 0.647362 | 3 | 0 | 3 |
| SLFN5 | ALCAM | 0.647248 | 4 | 0 | 4 |
| SLFN5 | SUMO1 | 0.642374 | 4 | 0 | 3 |
| SLFN5 | FSTL1 | 0.642195 | 3 | 0 | 3 |
| SLFN5 | ENTPD1 | 0.641504 | 3 | 0 | 3 |
| SLFN5 | FNDC3B | 0.641254 | 4 | 0 | 3 |
For details and further investigation, click here
