DIRAS1

 

Full name: DIRAS family GTPase 1 Alias Symbol: Di-Ras1|GBTS1|RIG
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 148252 HGNC ID: HGNC:19127 Ensembl Gene: ENSG00000176490 OMIM ID: 607862
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DIRAS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DIRAS1 148252 226573_at -0.2587 0.7105
GSE26886 DIRAS1 148252 226573_at -0.0524 0.8058
GSE45670 DIRAS1 148252 226573_at -0.0624 0.5726
GSE53622 DIRAS1 148252 23440 0.0267 0.7919
GSE53624 DIRAS1 148252 23440 0.1307 0.2612
GSE63941 DIRAS1 148252 226573_at -0.1013 0.8181
GSE77861 DIRAS1 148252 226573_at 0.0192 0.8626
GSE97050 DIRAS1 148252 A_23_P386942 -0.1454 0.5693
SRP064894 DIRAS1 148252 RNAseq -0.0763 0.8690
SRP133303 DIRAS1 148252 RNAseq -0.9356 0.0765
SRP159526 DIRAS1 148252 RNAseq -0.2258 0.6699
SRP219564 DIRAS1 148252 RNAseq 0.2349 0.7830
TCGA DIRAS1 148252 RNAseq -0.7576 0.0039

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by DIRAS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of DIRAS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DIRAS1 148252 4 4 22
GSE20123 DIRAS1 148252 3 4 23
GSE43470 DIRAS1 148252 1 9 33
GSE46452 DIRAS1 148252 47 1 11
GSE47630 DIRAS1 148252 5 7 28
GSE54993 DIRAS1 148252 16 3 51
GSE54994 DIRAS1 148252 8 16 29
GSE60625 DIRAS1 148252 9 0 2
GSE74703 DIRAS1 148252 1 6 29
GSE74704 DIRAS1 148252 1 3 16
TCGA DIRAS1 148252 7 23 66

Total number of gains: 102; Total number of losses: 76; Total Number of normals: 310.  


 

Somatic mutations of DIRAS1:

 

Generating mutation plots.

 

Highly correlated genes for DIRAS1:

 

Showing top 20/202 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DIRAS1FRZB0.78512303
DIRAS1PLCL10.769223303
DIRAS1TSPYL20.76869303
DIRAS1GPC40.766238303
DIRAS1RXRG0.761405303
DIRAS1TBC1D170.741346303
DIRAS1NR1H20.723892303
DIRAS1ARHGAP40.72374404
DIRAS1SGCA0.723352303
DIRAS1PLA2G4C0.722141303
DIRAS1FCHO10.718135404
DIRAS1GYPC0.716107303
DIRAS1SGCD0.711288303
DIRAS1TCEA20.70855303
DIRAS1KLF160.699092303
DIRAS1BHMT20.698504404
DIRAS1INSRR0.693846403
DIRAS1KANK20.692887303
DIRAS1CNTNAP10.6902404
DIRAS1EPHA30.69002403

For details and further investigation, click here