Full name: frataxin	Alias Symbol: FA|FARR|X25|CyaY
Type: protein-coding gene	Cytoband: 9q21.11
Entrez ID: 2395	HGNC ID: HGNC:3951	Ensembl Gene: ENSG00000165060	OMIM ID: 606829
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 110/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

Expression of FXN:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	FXN	2395	205565_s_at	0.3371	0.4068	Show
GSE20347	FXN	2395	205565_s_at	0.5149	0.0098	Show
GSE23400	FXN	2395	205565_s_at	0.2095	0.0001	Show
GSE26886	FXN	2395	205565_s_at	0.3654	0.0071	Show
GSE29001	FXN	2395	205565_s_at	0.3297	0.1435	Show
GSE38129	FXN	2395	205565_s_at	0.6069	0.0005	Show
GSE45670	FXN	2395	205565_s_at	0.3695	0.0256	Show
GSE53622	FXN	2395	67046	0.2966	0.0001	Show
GSE53624	FXN	2395	67046	0.5967	0.0000	Show
GSE63941	FXN	2395	205565_s_at	0.3535	0.5650	Show
GSE77861	FXN	2395	205565_s_at	0.1282	0.3117	Show
GSE97050	FXN	2395	A_33_P3319161	0.0056	0.9832	Show
SRP007169	FXN	2395	RNAseq	0.9888	0.0443	Show
SRP008496	FXN	2395	RNAseq	1.0209	0.0041	Show
SRP064894	FXN	2395	RNAseq	0.5167	0.0122	Show
SRP133303	FXN	2395	RNAseq	0.0532	0.7146	Show
SRP159526	FXN	2395	RNAseq	0.3158	0.3428	Show
SRP193095	FXN	2395	RNAseq	0.2006	0.0700	Show
SRP219564	FXN	2395	RNAseq	-0.0362	0.9301	Show
TCGA	FXN	2395	RNAseq	-0.1158	0.0850	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

---

 

Survival by FXN expression:

 

---

Copy number change of FXN:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	FXN	2395	6	10	14	Show
GSE20123	FXN	2395	6	10	14	Show
GSE43470	FXN	2395	6	5	32	Show
GSE46452	FXN	2395	7	14	38	Show
GSE47630	FXN	2395	1	19	20	Show
GSE54993	FXN	2395	5	1	64	Show
GSE54994	FXN	2395	4	13	36	Show
GSE60625	FXN	2395	0	0	11	Show
GSE74703	FXN	2395	5	4	27	Show
GSE74704	FXN	2395	3	7	10	Show
TCGA	FXN	2395	18	28	50	Show

Total number of gains: 61; Total number of losses: 111; Total Number of normals: 316.  Download Data

---

 

Somatic mutations of FXN:

 

---

 

Highly correlated genes for FXN:

 

Showing top 20/1003 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
FXN	FHOD3	0.72268	3	0	3
FXN	DNAJC19	0.706078	3	0	3
FXN	NNT	0.697292	3	0	3
FXN	RNF26	0.696171	3	0	3
FXN	NAE1	0.666016	5	0	4
FXN	SRI	0.661753	5	0	5
FXN	ZBTB8A	0.661266	3	0	3
FXN	HPS3	0.658253	4	0	3
FXN	RAB32	0.656002	7	0	7
FXN	ATG4C	0.654897	3	0	3
FXN	FAM171B	0.65347	4	0	4
FXN	SNRNP25	0.653136	11	0	9
FXN	TMEM216	0.647222	4	0	4
FXN	PHTF1	0.645068	3	0	3
FXN	SMARCAD1	0.644039	3	0	3
FXN	TWISTNB	0.636652	4	0	4
FXN	TRIM44	0.636457	4	0	4
FXN	CDK4	0.636285	11	0	9
FXN	ELP2	0.633729	3	0	3
FXN	NR2F2	0.63297	3	0	3

For details and further investigation, click here