| Full name: serine peptidase inhibitor, Kunitz type 2 | Alias Symbol: Kop|HAI-2 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 10653 | HGNC ID: HGNC:11247 | Ensembl Gene: ENSG00000167642 | OMIM ID: 605124 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SPINT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINT2 | 10653 | 210715_s_at | 0.2091 | 0.7523 | |
| GSE20347 | SPINT2 | 10653 | 210715_s_at | -0.2585 | 0.2177 | |
| GSE23400 | SPINT2 | 10653 | 210715_s_at | 0.2377 | 0.0914 | |
| GSE26886 | SPINT2 | 10653 | 210715_s_at | -0.7017 | 0.0002 | |
| GSE29001 | SPINT2 | 10653 | 210715_s_at | -0.1371 | 0.6854 | |
| GSE38129 | SPINT2 | 10653 | 210715_s_at | 0.6929 | 0.0434 | |
| GSE45670 | SPINT2 | 10653 | 210715_s_at | 0.3660 | 0.0413 | |
| GSE53622 | SPINT2 | 10653 | 94470 | 0.2342 | 0.2523 | |
| GSE53624 | SPINT2 | 10653 | 94470 | 0.1195 | 0.0878 | |
| GSE63941 | SPINT2 | 10653 | 210715_s_at | 6.5217 | 0.0001 | |
| GSE77861 | SPINT2 | 10653 | 210715_s_at | 0.1368 | 0.5875 | |
| GSE97050 | SPINT2 | 10653 | A_23_P27795 | 1.0972 | 0.3673 | |
| SRP007169 | SPINT2 | 10653 | RNAseq | -0.2305 | 0.6761 | |
| SRP008496 | SPINT2 | 10653 | RNAseq | -0.4145 | 0.3154 | |
| SRP064894 | SPINT2 | 10653 | RNAseq | 0.4538 | 0.2361 | |
| SRP133303 | SPINT2 | 10653 | RNAseq | 0.3143 | 0.1926 | |
| SRP159526 | SPINT2 | 10653 | RNAseq | 0.0319 | 0.9212 | |
| SRP193095 | SPINT2 | 10653 | RNAseq | -0.4818 | 0.0018 | |
| SRP219564 | SPINT2 | 10653 | RNAseq | -0.1095 | 0.9001 | |
| TCGA | SPINT2 | 10653 | RNAseq | 0.2464 | 0.0025 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPINT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINT2 | 10653 | 7 | 4 | 19 | |
| GSE20123 | SPINT2 | 10653 | 7 | 3 | 20 | |
| GSE43470 | SPINT2 | 10653 | 4 | 10 | 29 | |
| GSE46452 | SPINT2 | 10653 | 47 | 2 | 10 | |
| GSE47630 | SPINT2 | 10653 | 9 | 5 | 26 | |
| GSE54993 | SPINT2 | 10653 | 17 | 3 | 50 | |
| GSE54994 | SPINT2 | 10653 | 6 | 9 | 38 | |
| GSE60625 | SPINT2 | 10653 | 9 | 0 | 2 | |
| GSE74703 | SPINT2 | 10653 | 4 | 6 | 26 | |
| GSE74704 | SPINT2 | 10653 | 7 | 1 | 12 | |
| TCGA | SPINT2 | 10653 | 18 | 14 | 64 |
Total number of gains: 135; Total number of losses: 57; Total Number of normals: 296.
Somatic mutations of SPINT2:
Generating mutation plots.
Highly correlated genes for SPINT2:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINT2 | MAP7 | 0.780358 | 5 | 0 | 5 |
| SPINT2 | MARVELD2 | 0.770302 | 5 | 0 | 5 |
| SPINT2 | MAL2 | 0.763822 | 5 | 0 | 5 |
| SPINT2 | GALNT3 | 0.758602 | 6 | 0 | 6 |
| SPINT2 | ESRP1 | 0.747688 | 7 | 0 | 6 |
| SPINT2 | IRX3 | 0.718601 | 4 | 0 | 4 |
| SPINT2 | TLCD1 | 0.717947 | 4 | 0 | 4 |
| SPINT2 | STAP2 | 0.712539 | 5 | 0 | 4 |
| SPINT2 | SYTL1 | 0.708369 | 5 | 0 | 4 |
| SPINT2 | ESCO2 | 0.704418 | 3 | 0 | 3 |
| SPINT2 | FANCD2 | 0.703348 | 4 | 0 | 4 |
| SPINT2 | CDH1 | 0.695776 | 10 | 0 | 9 |
| SPINT2 | SRP68 | 0.689285 | 3 | 0 | 3 |
| SPINT2 | ARRDC1 | 0.685465 | 5 | 0 | 4 |
| SPINT2 | GRHL2 | 0.685105 | 7 | 0 | 5 |
| SPINT2 | PTBP3 | 0.68008 | 6 | 0 | 6 |
| SPINT2 | TFAP2A | 0.67854 | 8 | 0 | 7 |
| SPINT2 | C1orf210 | 0.673884 | 4 | 0 | 4 |
| SPINT2 | FXYD3 | 0.67138 | 10 | 0 | 9 |
| SPINT2 | ST14 | 0.670825 | 10 | 0 | 8 |
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