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Multi-Omics Database of ESCC

 

ZNF296

 

Full name: zinc finger protein 296 Alias Symbol: 
Type: protein-coding gene Cytoband: 19q13.32
Entrez ID: 162979 HGNC ID: HGNC:15981 Ensembl Gene: ENSG00000170684 OMIM ID: 613226
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF296:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF296 162979 238607_at -0.1655 0.7747
GSE26886 ZNF296 162979 238607_at -0.2832 0.1242
GSE45670 ZNF296 162979 238607_at -0.2008 0.2089
GSE53622 ZNF296 162979 16134 -0.4245 0.0006
GSE53624 ZNF296 162979 16134 -0.3267 0.0000
GSE63941 ZNF296 162979 238607_at 1.0362 0.0001
GSE77861 ZNF296 162979 238607_at -0.2666 0.1432
GSE97050 ZNF296 162979 A_23_P16058 0.6076 0.2281
SRP007169 ZNF296 162979 RNAseq -2.0910 0.0003
SRP064894 ZNF296 162979 RNAseq -0.5480 0.0950
SRP133303 ZNF296 162979 RNAseq -0.7588 0.0218
SRP159526 ZNF296 162979 RNAseq -0.8852 0.0103
SRP193095 ZNF296 162979 RNAseq -0.8445 0.0000
SRP219564 ZNF296 162979 RNAseq -0.7256 0.3220
TCGA ZNF296 162979 RNAseq 0.2583 0.0380

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by ZNF296 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF296:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF296 162979 4 5 21
GSE20123 ZNF296 162979 4 4 22
GSE43470 ZNF296 162979 3 11 29
GSE46452 ZNF296 162979 45 1 13
GSE47630 ZNF296 162979 8 6 26
GSE54993 ZNF296 162979 17 4 49
GSE54994 ZNF296 162979 6 12 35
GSE60625 ZNF296 162979 9 0 2
GSE74703 ZNF296 162979 3 7 26
GSE74704 ZNF296 162979 4 2 14
TCGA ZNF296 162979 14 17 65

Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.  

 

Somatic mutations of ZNF296:

 

Generating mutation plots.

 

Highly correlated genes for ZNF296:

 

Showing top 20/308 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF296FXYD30.7382303
ZNF296MYO1G0.710523303
ZNF296RPL350.682593303
ZNF296RARG0.679931605
ZNF296CITED40.673774303
ZNF296CDS10.666688403
ZNF296NDUFA30.663387303
ZNF296PSTK0.6627303
ZNF296S100A110.656646604
ZNF296TMEM2380.655281504
ZNF296STAP20.654811504
ZNF296ITGB70.653701504
ZNF296LLGL20.651333604
ZNF296CDC42BPG0.646495504
ZNF296GNA150.645104504
ZNF296RPRD20.642418303
ZNF296TNFRSF13B0.640765303
ZNF296SPINT20.636106403
ZNF296ODF3B0.635047303
ZNF296GPR870.633168503

For details and further investigation, click here