| Full name: FXYD domain containing ion transport regulator 4 | Alias Symbol: CHIF | ||
| Type: protein-coding gene | Cytoband: 10q11.21 | ||
| Entrez ID: 53828 | HGNC ID: HGNC:4028 | Ensembl Gene: ENSG00000150201 | OMIM ID: 616926 |
| Drug and gene relationship at DGIdb | |||
FXYD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of FXYD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FXYD4 | 53828 | 231058_at | 0.1312 | 0.5356 | |
| GSE26886 | FXYD4 | 53828 | 231058_at | 0.0365 | 0.7534 | |
| GSE45670 | FXYD4 | 53828 | 231058_at | 0.2539 | 0.0106 | |
| GSE53622 | FXYD4 | 53828 | 1492 | 0.2524 | 0.1047 | |
| GSE53624 | FXYD4 | 53828 | 1492 | 0.0973 | 0.5087 | |
| GSE63941 | FXYD4 | 53828 | 231058_at | 0.1822 | 0.2037 | |
| GSE77861 | FXYD4 | 53828 | 231058_at | 0.0196 | 0.8950 | |
| GSE97050 | FXYD4 | 53828 | A_23_P98121 | 0.1072 | 0.5993 | |
| TCGA | FXYD4 | 53828 | RNAseq | -5.2683 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FXYD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FXYD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FXYD4 | 53828 | 2 | 5 | 23 | |
| GSE20123 | FXYD4 | 53828 | 3 | 4 | 23 | |
| GSE43470 | FXYD4 | 53828 | 1 | 6 | 36 | |
| GSE46452 | FXYD4 | 53828 | 0 | 13 | 46 | |
| GSE47630 | FXYD4 | 53828 | 4 | 12 | 24 | |
| GSE54993 | FXYD4 | 53828 | 9 | 0 | 61 | |
| GSE54994 | FXYD4 | 53828 | 2 | 10 | 41 | |
| GSE60625 | FXYD4 | 53828 | 0 | 0 | 11 | |
| GSE74703 | FXYD4 | 53828 | 1 | 3 | 32 | |
| GSE74704 | FXYD4 | 53828 | 2 | 3 | 15 | |
| TCGA | FXYD4 | 53828 | 15 | 19 | 62 |
Total number of gains: 39; Total number of losses: 75; Total Number of normals: 374.
Somatic mutations of FXYD4:
Generating mutation plots.
Highly correlated genes for FXYD4:
Showing top 20/41 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FXYD4 | RPP25 | 0.726097 | 3 | 0 | 3 |
| FXYD4 | TMEM229A | 0.703467 | 3 | 0 | 3 |
| FXYD4 | NEUROG1 | 0.680767 | 3 | 0 | 3 |
| FXYD4 | RELB | 0.674035 | 4 | 0 | 3 |
| FXYD4 | CLPB | 0.672834 | 3 | 0 | 3 |
| FXYD4 | RUNDC3A | 0.638292 | 4 | 0 | 3 |
| FXYD4 | PPM1J | 0.631225 | 4 | 0 | 3 |
| FXYD4 | TEX13B | 0.627195 | 4 | 0 | 4 |
| FXYD4 | ASPHD1 | 0.622532 | 5 | 0 | 4 |
| FXYD4 | ACTR3B | 0.621254 | 4 | 0 | 3 |
| FXYD4 | SPACA1 | 0.620641 | 4 | 0 | 3 |
| FXYD4 | BPIFC | 0.618537 | 3 | 0 | 3 |
| FXYD4 | LINC01293 | 0.618208 | 3 | 0 | 3 |
| FXYD4 | DNAH6 | 0.601836 | 4 | 0 | 3 |
| FXYD4 | KRTAP9-9 | 0.599268 | 4 | 0 | 4 |
| FXYD4 | CDCA5 | 0.592366 | 4 | 0 | 3 |
| FXYD4 | CLCN2 | 0.591765 | 3 | 0 | 3 |
| FXYD4 | CTSE | 0.583465 | 4 | 0 | 3 |
| FXYD4 | PHGR1 | 0.578334 | 5 | 0 | 3 |
| FXYD4 | MIB2 | 0.570542 | 3 | 0 | 3 |
For details and further investigation, click here
