| Full name: chloride voltage-gated channel 2 | Alias Symbol: CLC2|EJM6|ClC-2 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 1181 | HGNC ID: HGNC:2020 | Ensembl Gene: ENSG00000114859 | OMIM ID: 600570 |
| Drug and gene relationship at DGIdb | |||
Expression of CLCN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCN2 | 1181 | 213499_at | 0.3640 | 0.2333 | |
| GSE20347 | CLCN2 | 1181 | 213499_at | 0.3321 | 0.0019 | |
| GSE23400 | CLCN2 | 1181 | 213499_at | 0.0137 | 0.7225 | |
| GSE26886 | CLCN2 | 1181 | 213499_at | 0.3026 | 0.0435 | |
| GSE29001 | CLCN2 | 1181 | 213499_at | 0.2322 | 0.0695 | |
| GSE38129 | CLCN2 | 1181 | 213499_at | 0.3695 | 0.0002 | |
| GSE45670 | CLCN2 | 1181 | 213499_at | 0.2954 | 0.0740 | |
| GSE53622 | CLCN2 | 1181 | 81775 | 1.1031 | 0.0000 | |
| GSE53624 | CLCN2 | 1181 | 81775 | 1.1172 | 0.0000 | |
| GSE63941 | CLCN2 | 1181 | 213499_at | 0.8428 | 0.0077 | |
| GSE77861 | CLCN2 | 1181 | 213499_at | -0.0177 | 0.9413 | |
| GSE97050 | CLCN2 | 1181 | A_23_P132845 | 0.5937 | 0.1269 | |
| SRP007169 | CLCN2 | 1181 | RNAseq | 2.8990 | 0.0002 | |
| SRP008496 | CLCN2 | 1181 | RNAseq | 2.3435 | 0.0000 | |
| SRP064894 | CLCN2 | 1181 | RNAseq | 1.1504 | 0.0000 | |
| SRP133303 | CLCN2 | 1181 | RNAseq | 1.0082 | 0.0001 | |
| SRP159526 | CLCN2 | 1181 | RNAseq | 2.4289 | 0.0000 | |
| SRP193095 | CLCN2 | 1181 | RNAseq | 0.7088 | 0.0013 | |
| SRP219564 | CLCN2 | 1181 | RNAseq | 0.7888 | 0.0105 | |
| TCGA | CLCN2 | 1181 | RNAseq | 0.4273 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CLCN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLCN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCN2 | 1181 | 25 | 0 | 5 | |
| GSE20123 | CLCN2 | 1181 | 25 | 0 | 5 | |
| GSE43470 | CLCN2 | 1181 | 25 | 0 | 18 | |
| GSE46452 | CLCN2 | 1181 | 19 | 1 | 39 | |
| GSE47630 | CLCN2 | 1181 | 27 | 2 | 11 | |
| GSE54993 | CLCN2 | 1181 | 1 | 19 | 50 | |
| GSE54994 | CLCN2 | 1181 | 41 | 0 | 12 | |
| GSE60625 | CLCN2 | 1181 | 0 | 6 | 5 | |
| GSE74703 | CLCN2 | 1181 | 21 | 0 | 15 | |
| GSE74704 | CLCN2 | 1181 | 17 | 0 | 3 | |
| TCGA | CLCN2 | 1181 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of CLCN2:
Generating mutation plots.
Highly correlated genes for CLCN2:
Showing top 20/516 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCN2 | CDRT15 | 0.74633 | 3 | 0 | 3 |
| CLCN2 | GPR39 | 0.740688 | 3 | 0 | 3 |
| CLCN2 | RASGEF1A | 0.722162 | 3 | 0 | 3 |
| CLCN2 | C19orf48 | 0.688506 | 3 | 0 | 3 |
| CLCN2 | PGP | 0.683017 | 4 | 0 | 4 |
| CLCN2 | TMEM59L | 0.676116 | 3 | 0 | 3 |
| CLCN2 | KNSTRN | 0.674171 | 5 | 0 | 4 |
| CLCN2 | KCNH3 | 0.663305 | 3 | 0 | 3 |
| CLCN2 | FOXJ1 | 0.66152 | 3 | 0 | 3 |
| CLCN2 | NTRK1 | 0.65914 | 3 | 0 | 3 |
| CLCN2 | TTYH3 | 0.658765 | 3 | 0 | 3 |
| CLCN2 | PDIA2 | 0.654899 | 4 | 0 | 3 |
| CLCN2 | CCDC114 | 0.651949 | 4 | 0 | 4 |
| CLCN2 | ECE2 | 0.650751 | 8 | 0 | 7 |
| CLCN2 | GPR17 | 0.648046 | 3 | 0 | 3 |
| CLCN2 | ALG3 | 0.646885 | 10 | 0 | 9 |
| CLCN2 | IGF2BP2 | 0.646793 | 8 | 0 | 8 |
| CLCN2 | POLR2H | 0.645863 | 11 | 0 | 9 |
| CLCN2 | CEP19 | 0.6441 | 6 | 0 | 5 |
| CLCN2 | LRWD1 | 0.643281 | 3 | 0 | 3 |
For details and further investigation, click here
