RRM1

 

Full name: ribonucleotide reductase catalytic subunit M1 Alias Symbol: 
Type: protein-coding gene Cytoband: 11p15.4
Entrez ID: 6240 HGNC ID: HGNC:10451 Ensembl Gene: ENSG00000167325 OMIM ID: 180410
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RRM1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RRM1 6240 201477_s_at 0.4975 0.3129
GSE20347 RRM1 6240 201477_s_at 0.6614 0.0004
GSE23400 RRM1 6240 201477_s_at 0.9865 0.0000
GSE26886 RRM1 6240 201477_s_at 0.8227 0.0001
GSE29001 RRM1 6240 201477_s_at 0.5621 0.0673
GSE38129 RRM1 6240 201477_s_at 0.8158 0.0000
GSE45670 RRM1 6240 201477_s_at 0.6701 0.0001
GSE53622 RRM1 6240 153048 0.3892 0.0000
GSE53624 RRM1 6240 153048 0.6229 0.0000
GSE63941 RRM1 6240 201477_s_at 0.8723 0.1105
GSE77861 RRM1 6240 201477_s_at 0.2538 0.5834
GSE97050 RRM1 6240 A_23_P87351 0.1924 0.5222
SRP007169 RRM1 6240 RNAseq 0.7325 0.1159
SRP008496 RRM1 6240 RNAseq 0.7856 0.0064
SRP064894 RRM1 6240 RNAseq 0.4170 0.0439
SRP133303 RRM1 6240 RNAseq 0.5121 0.0010
SRP159526 RRM1 6240 RNAseq 0.3393 0.2519
SRP193095 RRM1 6240 RNAseq 0.3113 0.0566
SRP219564 RRM1 6240 RNAseq 0.0905 0.7674
TCGA RRM1 6240 RNAseq 0.2572 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RRM1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RRM1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RRM1 6240 1 12 17
GSE20123 RRM1 6240 1 11 18
GSE43470 RRM1 6240 1 7 35
GSE46452 RRM1 6240 7 8 44
GSE47630 RRM1 6240 4 13 23
GSE54993 RRM1 6240 3 1 66
GSE54994 RRM1 6240 1 12 40
GSE60625 RRM1 6240 0 0 11
GSE74703 RRM1 6240 1 6 29
GSE74704 RRM1 6240 0 8 12
TCGA RRM1 6240 8 38 50

Total number of gains: 27; Total number of losses: 116; Total Number of normals: 345.  

 

Somatic mutations of RRM1:

 

Generating mutation plots.

 

Highly correlated genes for RRM1:

 

Showing top 20/1434 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RRM1NAA380.778558303
RRM1HRH10.762022303
RRM1ZNF6070.743859303
RRM1PIK3R30.73202303
RRM1HDDC30.72326303
RRM1DKC10.712092303
RRM1NCAPG0.7102981009
RRM1CENPL0.706982707
RRM1PSMG30.704944606
RRM1LRRC580.704057404
RRM1GLT8D10.703353303
RRM1CMC10.697977303
RRM1MELK0.696211011
RRM1CPSF30.693569707
RRM1MAD2L10.689369909
RRM1RMI10.68872912012
RRM1GINS10.68688712011
RRM1NDC800.6866211010
RRM1ATR0.68556810010
RRM1COLEC110.684157303

For details and further investigation, click here