FIGNL1

 

Full name: fidgetin like 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 7p12.2
Entrez ID: 63979 HGNC ID: HGNC:13286 Ensembl Gene: ENSG00000132436 OMIM ID: 615383
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FIGNL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FIGNL1 63979 222843_at 0.6104 0.1262
GSE26886 FIGNL1 63979 222843_at 0.6565 0.0190
GSE45670 FIGNL1 63979 222843_at 0.7993 0.0001
GSE53622 FIGNL1 63979 13853 0.6842 0.0000
GSE53624 FIGNL1 63979 13853 0.8048 0.0000
GSE63941 FIGNL1 63979 222843_at 1.6780 0.0004
GSE77861 FIGNL1 63979 222843_at 0.4432 0.3261
GSE97050 FIGNL1 63979 A_23_P302681 0.4985 0.2956
SRP007169 FIGNL1 63979 RNAseq 0.6030 0.1117
SRP008496 FIGNL1 63979 RNAseq 1.0640 0.0024
SRP064894 FIGNL1 63979 RNAseq 0.2656 0.3345
SRP133303 FIGNL1 63979 RNAseq 0.5914 0.0064
SRP159526 FIGNL1 63979 RNAseq 0.5690 0.0213
SRP193095 FIGNL1 63979 RNAseq 0.3377 0.0350
SRP219564 FIGNL1 63979 RNAseq 0.1972 0.7292
TCGA FIGNL1 63979 RNAseq 0.5067 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by FIGNL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FIGNL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FIGNL1 63979 12 0 18
GSE20123 FIGNL1 63979 11 0 19
GSE43470 FIGNL1 63979 4 1 38
GSE46452 FIGNL1 63979 11 1 47
GSE47630 FIGNL1 63979 8 1 31
GSE54993 FIGNL1 63979 0 8 62
GSE54994 FIGNL1 63979 18 2 33
GSE60625 FIGNL1 63979 0 0 11
GSE74703 FIGNL1 63979 4 1 31
GSE74704 FIGNL1 63979 5 0 15
TCGA FIGNL1 63979 48 10 38

Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.  

 

Somatic mutations of FIGNL1:

 

Generating mutation plots.

 

Highly correlated genes for FIGNL1:

 

Showing top 20/1330 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FIGNL1KIF150.79325707
FIGNL1EME10.756317505
FIGNL1MMS22L0.75347303
FIGNL1LRP80.753448404
FIGNL1KPNA20.748613505
FIGNL1UCK20.739661303
FIGNL1TTK0.737166808
FIGNL1GMNN0.735094908
FIGNL1DKC10.73502303
FIGNL1BLM0.72778808
FIGNL1DTL0.726916808
FIGNL1POLA20.72322606
FIGNL1CDK10.720357707
FIGNL1CENPF0.718903808
FIGNL1XPO50.718854706
FIGNL1GINS10.718743807
FIGNL1CCDC860.71845505
FIGNL1C1orf1120.718313605
FIGNL1BUB10.716382807
FIGNL1TOP2A0.714867605

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