| Full name: cyclin B1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q13.2 | ||
| Entrez ID: 891 | HGNC ID: HGNC:1579 | Ensembl Gene: ENSG00000134057 | OMIM ID: 123836 |
Screen Evidence:
| |||
CCNB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04115 | p53 signaling pathway |
Expression of CCNB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCNB1 | 891 | 214710_s_at | 1.1524 | 0.1308 | |
| GSE20347 | CCNB1 | 891 | 214710_s_at | 1.1552 | 0.0000 | |
| GSE23400 | CCNB1 | 891 | 214710_s_at | 1.6045 | 0.0000 | |
| GSE26886 | CCNB1 | 891 | 214710_s_at | -0.1715 | 0.6322 | |
| GSE29001 | CCNB1 | 891 | 214710_s_at | 1.3196 | 0.0203 | |
| GSE38129 | CCNB1 | 891 | 214710_s_at | 1.8689 | 0.0000 | |
| GSE45670 | CCNB1 | 891 | 214710_s_at | 1.3093 | 0.0000 | |
| GSE53622 | CCNB1 | 891 | 135549 | 1.4971 | 0.0000 | |
| GSE53624 | CCNB1 | 891 | 14804 | 1.0100 | 0.0000 | |
| GSE63941 | CCNB1 | 891 | 214710_s_at | 2.8263 | 0.0001 | |
| GSE77861 | CCNB1 | 891 | 214710_s_at | 0.4855 | 0.3592 | |
| GSE97050 | CCNB1 | 891 | A_23_P122197 | 0.6955 | 0.5574 | |
| SRP007169 | CCNB1 | 891 | RNAseq | 1.9325 | 0.0000 | |
| SRP008496 | CCNB1 | 891 | RNAseq | 1.2460 | 0.0007 | |
| SRP064894 | CCNB1 | 891 | RNAseq | 1.2698 | 0.0001 | |
| SRP133303 | CCNB1 | 891 | RNAseq | 1.2207 | 0.0000 | |
| SRP159526 | CCNB1 | 891 | RNAseq | 1.1135 | 0.0036 | |
| SRP193095 | CCNB1 | 891 | RNAseq | 0.7155 | 0.0002 | |
| SRP219564 | CCNB1 | 891 | RNAseq | 0.5637 | 0.4831 | |
| TCGA | CCNB1 | 891 | RNAseq | 0.9601 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by CCNB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCNB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCNB1 | 891 | 1 | 13 | 16 | |
| GSE20123 | CCNB1 | 891 | 1 | 13 | 16 | |
| GSE43470 | CCNB1 | 891 | 1 | 12 | 30 | |
| GSE46452 | CCNB1 | 891 | 0 | 28 | 31 | |
| GSE47630 | CCNB1 | 891 | 2 | 17 | 21 | |
| GSE54993 | CCNB1 | 891 | 8 | 1 | 61 | |
| GSE54994 | CCNB1 | 891 | 1 | 21 | 31 | |
| GSE60625 | CCNB1 | 891 | 0 | 0 | 11 | |
| GSE74703 | CCNB1 | 891 | 1 | 9 | 26 | |
| GSE74704 | CCNB1 | 891 | 1 | 6 | 13 | |
| TCGA | CCNB1 | 891 | 4 | 51 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of CCNB1:
Generating mutation plots.
Highly correlated genes for CCNB1:
Showing top 20/1488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCNB1 | MELK | 0.809629 | 12 | 0 | 12 |
| CCNB1 | DLGAP5 | 0.801093 | 13 | 0 | 12 |
| CCNB1 | TPX2 | 0.799056 | 12 | 0 | 12 |
| CCNB1 | CDK1 | 0.798202 | 12 | 0 | 12 |
| CCNB1 | KIF4A | 0.781468 | 11 | 0 | 11 |
| CCNB1 | HMMR | 0.779544 | 13 | 0 | 13 |
| CCNB1 | MKI67 | 0.777943 | 12 | 0 | 12 |
| CCNB1 | AURKB | 0.775832 | 12 | 0 | 12 |
| CCNB1 | KIF23 | 0.773242 | 12 | 0 | 12 |
| CCNB1 | CKS1B | 0.773103 | 11 | 0 | 11 |
| CCNB1 | KIF20A | 0.770324 | 13 | 0 | 12 |
| CCNB1 | PBK | 0.767555 | 13 | 0 | 13 |
| CCNB1 | CEP55 | 0.767402 | 13 | 0 | 12 |
| CCNB1 | CDC20 | 0.765466 | 13 | 0 | 11 |
| CCNB1 | ANLN | 0.763902 | 8 | 0 | 7 |
| CCNB1 | MCM4 | 0.762951 | 11 | 0 | 10 |
| CCNB1 | CBX3 | 0.762665 | 9 | 0 | 9 |
| CCNB1 | ATAD2 | 0.762568 | 12 | 0 | 12 |
| CCNB1 | RNASEH2A | 0.762037 | 11 | 0 | 11 |
| CCNB1 | BUB1B | 0.760823 | 10 | 0 | 9 |
For details and further investigation, click here
