| Full name: gamma-aminobutyric acid type A receptor pi subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.1 | ||
| Entrez ID: 2568 | HGNC ID: HGNC:4089 | Ensembl Gene: ENSG00000094755 | OMIM ID: 602729 |
| Drug and gene relationship at DGIdb | |||
GABRP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRP | 2568 | 205044_at | -2.4620 | 0.1318 | |
| GSE20347 | GABRP | 2568 | 205044_at | -2.9411 | 0.0001 | |
| GSE23400 | GABRP | 2568 | 205044_at | -2.4830 | 0.0000 | |
| GSE26886 | GABRP | 2568 | 205044_at | -5.3665 | 0.0000 | |
| GSE29001 | GABRP | 2568 | 205044_at | -2.4520 | 0.0194 | |
| GSE38129 | GABRP | 2568 | 205044_at | -2.1095 | 0.0015 | |
| GSE45670 | GABRP | 2568 | 205044_at | -2.0080 | 0.0302 | |
| GSE63941 | GABRP | 2568 | 205044_at | 1.5018 | 0.4363 | |
| GSE77861 | GABRP | 2568 | 205044_at | -2.8901 | 0.0257 | |
| GSE97050 | GABRP | 2568 | A_23_P328545 | -1.4224 | 0.1453 | |
| SRP007169 | GABRP | 2568 | RNAseq | -3.6390 | 0.0003 | |
| SRP008496 | GABRP | 2568 | RNAseq | -4.7252 | 0.0000 | |
| SRP064894 | GABRP | 2568 | RNAseq | -3.0712 | 0.0000 | |
| SRP133303 | GABRP | 2568 | RNAseq | -2.4518 | 0.0017 | |
| SRP159526 | GABRP | 2568 | RNAseq | -2.3846 | 0.0384 | |
| SRP193095 | GABRP | 2568 | RNAseq | -2.8770 | 0.0000 | |
| SRP219564 | GABRP | 2568 | RNAseq | -3.2587 | 0.0041 | |
| TCGA | GABRP | 2568 | RNAseq | -0.1235 | 0.7858 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by GABRP expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GABRP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRP | 2568 | 1 | 13 | 16 | |
| GSE20123 | GABRP | 2568 | 1 | 13 | 16 | |
| GSE43470 | GABRP | 2568 | 1 | 10 | 32 | |
| GSE46452 | GABRP | 2568 | 0 | 27 | 32 | |
| GSE47630 | GABRP | 2568 | 0 | 20 | 20 | |
| GSE54993 | GABRP | 2568 | 9 | 2 | 59 | |
| GSE54994 | GABRP | 2568 | 2 | 15 | 36 | |
| GSE60625 | GABRP | 2568 | 1 | 0 | 10 | |
| GSE74703 | GABRP | 2568 | 1 | 7 | 28 | |
| GSE74704 | GABRP | 2568 | 0 | 6 | 14 | |
| TCGA | GABRP | 2568 | 7 | 36 | 53 |
Total number of gains: 23; Total number of losses: 149; Total Number of normals: 316.
Somatic mutations of GABRP:
Generating mutation plots.
Highly correlated genes for GABRP:
Showing top 20/983 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRP | ATP13A4 | 0.786819 | 5 | 0 | 5 |
| GABRP | TCP11L2 | 0.765939 | 3 | 0 | 3 |
| GABRP | SLC44A2 | 0.762315 | 3 | 0 | 3 |
| GABRP | CRISP3 | 0.745269 | 9 | 0 | 9 |
| GABRP | CGNL1 | 0.744454 | 4 | 0 | 4 |
| GABRP | FAM214A | 0.737231 | 4 | 0 | 4 |
| GABRP | A2ML1 | 0.735482 | 5 | 0 | 5 |
| GABRP | GDPD3 | 0.721169 | 9 | 0 | 8 |
| GABRP | KLB | 0.719451 | 4 | 0 | 4 |
| GABRP | FLG-AS1 | 0.717876 | 4 | 0 | 4 |
| GABRP | IL36A | 0.717031 | 9 | 0 | 9 |
| GABRP | UPK1A | 0.714137 | 9 | 0 | 8 |
| GABRP | TMPRSS11E | 0.713741 | 9 | 0 | 9 |
| GABRP | TGM3 | 0.713343 | 9 | 0 | 9 |
| GABRP | SIM2 | 0.71172 | 9 | 0 | 9 |
| GABRP | FAM3D | 0.711639 | 6 | 0 | 5 |
| GABRP | SPAG17 | 0.711615 | 5 | 0 | 4 |
| GABRP | RMND5B | 0.711334 | 8 | 0 | 8 |
| GABRP | CTTNBP2 | 0.710688 | 5 | 0 | 5 |
| GABRP | MAL2 | 0.710391 | 4 | 0 | 4 |
For details and further investigation, click here
