SETDB1

 

Full name: SET domain bifurcated histone lysine methyltransferase 1 Alias Symbol: KG1T|KIAA0067|ESET|KMT1E|TDRD21
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 9869 HGNC ID: HGNC:10761 Ensembl Gene: ENSG00000143379 OMIM ID: 604396
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of SETDB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SETDB1 9869 203155_at 0.5633 0.1398
GSE20347 SETDB1 9869 203155_at 0.3193 0.0010
GSE23400 SETDB1 9869 203155_at 0.2764 0.0000
GSE26886 SETDB1 9869 203155_at 0.2343 0.4082
GSE29001 SETDB1 9869 203155_at 0.3711 0.0556
GSE38129 SETDB1 9869 203155_at 0.4614 0.0000
GSE45670 SETDB1 9869 203155_at 0.2161 0.1511
GSE53622 SETDB1 9869 45793 0.2757 0.0000
GSE53624 SETDB1 9869 110041 0.1887 0.0003
GSE63941 SETDB1 9869 203155_at 0.4768 0.1674
GSE77861 SETDB1 9869 203155_at 0.4092 0.1142
GSE97050 SETDB1 9869 A_33_P3305399 0.1347 0.4764
SRP007169 SETDB1 9869 RNAseq 0.5444 0.1359
SRP008496 SETDB1 9869 RNAseq 0.7294 0.0236
SRP064894 SETDB1 9869 RNAseq 0.2545 0.0325
SRP133303 SETDB1 9869 RNAseq 0.0306 0.8431
SRP159526 SETDB1 9869 RNAseq 0.6925 0.0092
SRP193095 SETDB1 9869 RNAseq 0.5406 0.0000
SRP219564 SETDB1 9869 RNAseq 0.4147 0.3066
TCGA SETDB1 9869 RNAseq 0.0741 0.1468

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by SETDB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of SETDB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SETDB1 9869 15 0 15
GSE20123 SETDB1 9869 15 0 15
GSE43470 SETDB1 9869 6 1 36
GSE46452 SETDB1 9869 2 1 56
GSE47630 SETDB1 9869 14 0 26
GSE54993 SETDB1 9869 0 4 66
GSE54994 SETDB1 9869 15 0 38
GSE60625 SETDB1 9869 0 0 11
GSE74703 SETDB1 9869 6 1 29
GSE74704 SETDB1 9869 7 0 13
TCGA SETDB1 9869 37 2 57

Total number of gains: 117; Total number of losses: 9; Total Number of normals: 362.  


 

Somatic mutations of SETDB1:

 

Generating mutation plots.

 

Highly correlated genes for SETDB1:

 

Showing top 20/753 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SETDB1PDCD2L0.791853404
SETDB1PPP1R16A0.723567303
SETDB1CCM20.722302303
SETDB1RNF2170.714203303
SETDB1TULP40.705837403
SETDB1PCDH170.701336303
SETDB1TOP1MT0.680447403
SETDB1FADS30.678475303
SETDB1SFXN20.676584303
SETDB1C12orf730.676135303
SETDB1UHMK10.673106404
SETDB1PTPRJ0.671393303
SETDB1NACC10.671102303
SETDB1CRCP0.669178303
SETDB1GRAMD40.667962303
SETDB1CLK20.66775713012
SETDB1GPR1580.662443303
SETDB1C12orf450.660684403
SETDB1MMS190.657962303
SETDB1CHD60.655996403

For details and further investigation, click here