| Full name: glucosylceramidase beta 3 (gene/pseudogene) | Alias Symbol: GLUC|KLrP | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 57733 | HGNC ID: HGNC:19069 | Ensembl Gene: ENSG00000249948 | OMIM ID: 606619 |
| Drug and gene relationship at DGIdb | |||
Expression of GBA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBA3 | 57733 | 219954_s_at | -0.0910 | 0.8046 | |
| GSE20347 | GBA3 | 57733 | 219954_s_at | -0.0516 | 0.5425 | |
| GSE23400 | GBA3 | 57733 | 219954_s_at | -0.0732 | 0.0236 | |
| GSE26886 | GBA3 | 57733 | 219954_s_at | 0.0732 | 0.4691 | |
| GSE29001 | GBA3 | 57733 | 219954_s_at | -0.0523 | 0.7157 | |
| GSE38129 | GBA3 | 57733 | 219954_s_at | -0.0837 | 0.3199 | |
| GSE45670 | GBA3 | 57733 | 219954_s_at | 0.2514 | 0.4326 | |
| GSE53622 | GBA3 | 57733 | 28126 | 0.5588 | 0.0075 | |
| GSE53624 | GBA3 | 57733 | 28126 | 0.5554 | 0.0006 | |
| GSE63941 | GBA3 | 57733 | 219954_s_at | 0.0742 | 0.9141 | |
| GSE77861 | GBA3 | 57733 | 219954_s_at | -0.2008 | 0.0879 | |
| TCGA | GBA3 | 57733 | RNAseq | -0.7613 | 0.3767 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GBA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBA3 | 57733 | 0 | 18 | 12 | |
| GSE20123 | GBA3 | 57733 | 0 | 17 | 13 | |
| GSE43470 | GBA3 | 57733 | 0 | 15 | 28 | |
| GSE46452 | GBA3 | 57733 | 1 | 36 | 22 | |
| GSE47630 | GBA3 | 57733 | 1 | 19 | 20 | |
| GSE54993 | GBA3 | 57733 | 9 | 0 | 61 | |
| GSE54994 | GBA3 | 57733 | 4 | 11 | 38 | |
| GSE60625 | GBA3 | 57733 | 0 | 0 | 11 | |
| GSE74703 | GBA3 | 57733 | 0 | 13 | 23 | |
| GSE74704 | GBA3 | 57733 | 0 | 11 | 9 | |
| TCGA | GBA3 | 57733 | 11 | 47 | 38 |
Total number of gains: 26; Total number of losses: 187; Total Number of normals: 275.
Somatic mutations of GBA3:
Generating mutation plots.
Highly correlated genes for GBA3:
Showing top 20/348 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBA3 | ZNF460 | 0.679487 | 5 | 0 | 4 |
| GBA3 | ONECUT1 | 0.675064 | 4 | 0 | 3 |
| GBA3 | MS4A12 | 0.65634 | 3 | 0 | 3 |
| GBA3 | BSN | 0.646443 | 4 | 0 | 4 |
| GBA3 | REG1A | 0.641149 | 3 | 0 | 3 |
| GBA3 | GP2 | 0.634676 | 4 | 0 | 4 |
| GBA3 | AMPD1 | 0.634543 | 3 | 0 | 3 |
| GBA3 | SLC6A5 | 0.632741 | 3 | 0 | 3 |
| GBA3 | CCL25 | 0.632075 | 3 | 0 | 3 |
| GBA3 | SLC17A3 | 0.631214 | 4 | 0 | 3 |
| GBA3 | IL9 | 0.631111 | 3 | 0 | 3 |
| GBA3 | TCL1B | 0.629644 | 4 | 0 | 3 |
| GBA3 | PHLDB1 | 0.628266 | 4 | 0 | 3 |
| GBA3 | CNR1 | 0.628258 | 4 | 0 | 4 |
| GBA3 | ADAM18 | 0.627394 | 4 | 0 | 4 |
| GBA3 | MYL1 | 0.62352 | 4 | 0 | 3 |
| GBA3 | GABRA6 | 0.622707 | 4 | 0 | 3 |
| GBA3 | KLRC4 | 0.622274 | 3 | 0 | 3 |
| GBA3 | PRKACG | 0.620657 | 4 | 0 | 4 |
| GBA3 | LINC00895 | 0.620139 | 3 | 0 | 3 |
For details and further investigation, click here
