REG1A

 

Full name: regenerating family member 1 alpha Alias Symbol: PSP|PTP|PSPS|PSPS1
Type: protein-coding gene Cytoband: 2p12
Entrez ID: 5967 HGNC ID: HGNC:9951 Ensembl Gene: ENSG00000115386 OMIM ID: 167770
Drug and gene relationship at DGIdb

 

Expression of REG1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 REG1A 5967 209752_at 0.1344 0.7447
GSE20347 REG1A 5967 209752_at 0.1461 0.3941
GSE23400 REG1A 5967 209752_at -0.1112 0.0255
GSE26886 REG1A 5967 209752_at 0.1581 0.0561
GSE29001 REG1A 5967 209752_at 0.0032 0.9833
GSE38129 REG1A 5967 209752_at -0.4146 0.3130
GSE45670 REG1A 5967 209752_at 0.1128 0.3891
GSE53622 REG1A 5967 11174 0.7338 0.0880
GSE53624 REG1A 5967 11174 0.3755 0.3803
GSE63941 REG1A 5967 209752_at 0.1367 0.6819
GSE77861 REG1A 5967 209752_at -0.1986 0.0817
TCGA REG1A 5967 RNAseq -3.7954 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by REG1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of REG1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 REG1A 5967 9 2 19
GSE20123 REG1A 5967 8 2 20
GSE43470 REG1A 5967 4 0 39
GSE46452 REG1A 5967 2 3 54
GSE47630 REG1A 5967 7 0 33
GSE54993 REG1A 5967 0 6 64
GSE54994 REG1A 5967 10 0 43
GSE60625 REG1A 5967 0 3 8
GSE74703 REG1A 5967 4 0 32
GSE74704 REG1A 5967 5 1 14
TCGA REG1A 5967 36 3 57

Total number of gains: 85; Total number of losses: 20; Total Number of normals: 383.  

 

Somatic mutations of REG1A:

 

Generating mutation plots.

 

Highly correlated genes for REG1A:

 

Showing top 20/104 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
REG1AATP4B0.716474606
REG1ACLDN180.707229505
REG1ACKM0.701945303
REG1AATP4A0.697129606
REG1ASPINK10.689292505
REG1ALIPF0.684491505
REG1AGKN10.675195505
REG1AKRT200.668352504
REG1APGC0.659009606
REG1ATAAR50.653606303
REG1ACELA3A0.653328504
REG1ATUBAL30.652716303
REG1ACTSE0.652101705
REG1AGBA30.641149303
REG1AFUT90.640199504
REG1ACHIA0.640129605
REG1AAPOA10.637613403
REG1APPY0.635997303
REG1AFGR0.635562303
REG1ALINC014310.633534303

For details and further investigation, click here