| Full name: gamma-aminobutyric acid type A receptor alpha6 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q34 | ||
| Entrez ID: 2559 | HGNC ID: HGNC:4080 | Ensembl Gene: ENSG00000145863 | OMIM ID: 137143 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
GABRA6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa04742 | Taste transduction | |
| hsa05032 | Morphine addiction |
Expression of GABRA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRA6 | 2559 | 207182_at | -0.2225 | 0.3134 | |
| GSE20347 | GABRA6 | 2559 | 207182_at | -0.1658 | 0.0027 | |
| GSE23400 | GABRA6 | 2559 | 207182_at | -0.1332 | 0.0002 | |
| GSE26886 | GABRA6 | 2559 | 207182_at | -0.0561 | 0.5301 | |
| GSE29001 | GABRA6 | 2559 | 207182_at | -0.2020 | 0.1665 | |
| GSE38129 | GABRA6 | 2559 | 207182_at | -0.1643 | 0.0010 | |
| GSE45670 | GABRA6 | 2559 | 207182_at | -0.1031 | 0.2762 | |
| GSE63941 | GABRA6 | 2559 | 207182_at | -0.0371 | 0.7553 | |
| GSE77861 | GABRA6 | 2559 | 207182_at | -0.3479 | 0.0017 | |
| TCGA | GABRA6 | 2559 | RNAseq | 1.5996 | 0.4481 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GABRA6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GABRA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRA6 | 2559 | 0 | 12 | 18 | |
| GSE20123 | GABRA6 | 2559 | 0 | 12 | 18 | |
| GSE43470 | GABRA6 | 2559 | 2 | 10 | 31 | |
| GSE46452 | GABRA6 | 2559 | 0 | 27 | 32 | |
| GSE47630 | GABRA6 | 2559 | 0 | 20 | 20 | |
| GSE54993 | GABRA6 | 2559 | 9 | 2 | 59 | |
| GSE54994 | GABRA6 | 2559 | 2 | 15 | 36 | |
| GSE60625 | GABRA6 | 2559 | 0 | 0 | 11 | |
| GSE74703 | GABRA6 | 2559 | 2 | 8 | 26 | |
| GSE74704 | GABRA6 | 2559 | 0 | 7 | 13 | |
| TCGA | GABRA6 | 2559 | 6 | 37 | 53 |
Total number of gains: 21; Total number of losses: 150; Total Number of normals: 317.
Somatic mutations of GABRA6:
Generating mutation plots.
Highly correlated genes for GABRA6:
Showing top 20/852 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRA6 | IL12A-AS1 | 0.732336 | 3 | 0 | 3 |
| GABRA6 | C4orf3 | 0.709045 | 3 | 0 | 3 |
| GABRA6 | SLC25A27 | 0.705961 | 3 | 0 | 3 |
| GABRA6 | GGT6 | 0.693711 | 3 | 0 | 3 |
| GABRA6 | SLC46A2 | 0.692442 | 3 | 0 | 3 |
| GABRA6 | ACSM3 | 0.684744 | 4 | 0 | 3 |
| GABRA6 | RAET1E | 0.68023 | 3 | 0 | 3 |
| GABRA6 | PLEKHA7 | 0.672762 | 3 | 0 | 3 |
| GABRA6 | KRT78 | 0.667551 | 3 | 0 | 3 |
| GABRA6 | AIF1L | 0.667535 | 3 | 0 | 3 |
| GABRA6 | PRDM11 | 0.665183 | 4 | 0 | 3 |
| GABRA6 | LINC00330 | 0.664106 | 3 | 0 | 3 |
| GABRA6 | IL17RC | 0.663096 | 7 | 0 | 6 |
| GABRA6 | CCIN | 0.662135 | 5 | 0 | 5 |
| GABRA6 | KCNA2 | 0.660405 | 3 | 0 | 3 |
| GABRA6 | ARL6IP5 | 0.660381 | 3 | 0 | 3 |
| GABRA6 | FAM3D | 0.658927 | 3 | 0 | 3 |
| GABRA6 | LRRC31 | 0.658521 | 3 | 0 | 3 |
| GABRA6 | ASPG | 0.657882 | 3 | 0 | 3 |
| GABRA6 | DEGS2 | 0.655462 | 3 | 0 | 3 |
For details and further investigation, click here
