| Full name: methionyl-tRNA synthetase 2, mitochondrial | Alias Symbol: mtMetRS|SPAX3 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 92935 | HGNC ID: HGNC:25133 | Ensembl Gene: ENSG00000247626 | OMIM ID: 609728 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MARS2 | 92935 | 243529_at | 1.0165 | 0.0671 | |
| GSE26886 | MARS2 | 92935 | 243529_at | -0.9808 | 0.0004 | |
| GSE45670 | MARS2 | 92935 | 243529_at | 0.3732 | 0.0507 | |
| GSE63941 | MARS2 | 92935 | 243529_at | 0.7143 | 0.2065 | |
| GSE77861 | MARS2 | 92935 | 243529_at | -0.2072 | 0.2747 | |
| GSE97050 | MARS2 | 92935 | A_23_P108492 | 0.4123 | 0.2232 | |
| SRP007169 | MARS2 | 92935 | RNAseq | 0.0574 | 0.9031 | |
| SRP008496 | MARS2 | 92935 | RNAseq | -0.0812 | 0.7575 | |
| SRP064894 | MARS2 | 92935 | RNAseq | -0.3120 | 0.2864 | |
| SRP133303 | MARS2 | 92935 | RNAseq | 0.3411 | 0.0745 | |
| SRP159526 | MARS2 | 92935 | RNAseq | 0.0956 | 0.7515 | |
| SRP193095 | MARS2 | 92935 | RNAseq | 0.2142 | 0.0706 | |
| SRP219564 | MARS2 | 92935 | RNAseq | 0.1498 | 0.7330 | |
| TCGA | MARS2 | 92935 | RNAseq | -0.0223 | 0.7739 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MARS2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MARS2 | 92935 | 10 | 2 | 18 | |
| GSE20123 | MARS2 | 92935 | 10 | 2 | 18 | |
| GSE43470 | MARS2 | 92935 | 3 | 1 | 39 | |
| GSE46452 | MARS2 | 92935 | 1 | 4 | 54 | |
| GSE47630 | MARS2 | 92935 | 4 | 5 | 31 | |
| GSE54993 | MARS2 | 92935 | 0 | 3 | 67 | |
| GSE54994 | MARS2 | 92935 | 10 | 8 | 35 | |
| GSE60625 | MARS2 | 92935 | 0 | 3 | 8 | |
| GSE74703 | MARS2 | 92935 | 2 | 1 | 33 | |
| GSE74704 | MARS2 | 92935 | 5 | 2 | 13 | |
| TCGA | MARS2 | 92935 | 22 | 9 | 65 |
Total number of gains: 67; Total number of losses: 40; Total Number of normals: 381.
Somatic mutations of MARS2:
Generating mutation plots.
Highly correlated genes for MARS2:
Showing top 20/269 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MARS2 | CEP85 | 0.82936 | 3 | 0 | 3 |
| MARS2 | NAT10 | 0.795664 | 3 | 0 | 3 |
| MARS2 | TARBP1 | 0.773328 | 3 | 0 | 3 |
| MARS2 | NIF3L1 | 0.763711 | 4 | 0 | 4 |
| MARS2 | SEC61A1 | 0.757332 | 3 | 0 | 3 |
| MARS2 | CCDC58 | 0.747986 | 3 | 0 | 3 |
| MARS2 | ZXDC | 0.743152 | 3 | 0 | 3 |
| MARS2 | TKT | 0.738812 | 3 | 0 | 3 |
| MARS2 | UXS1 | 0.738004 | 3 | 0 | 3 |
| MARS2 | PTPN3 | 0.730386 | 3 | 0 | 3 |
| MARS2 | ZNF117 | 0.725896 | 3 | 0 | 3 |
| MARS2 | SREBF2 | 0.723334 | 3 | 0 | 3 |
| MARS2 | GBF1 | 0.718127 | 3 | 0 | 3 |
| MARS2 | DDX31 | 0.717505 | 3 | 0 | 3 |
| MARS2 | LEMD2 | 0.716027 | 3 | 0 | 3 |
| MARS2 | RLIM | 0.71526 | 3 | 0 | 3 |
| MARS2 | HECW2 | 0.713229 | 3 | 0 | 3 |
| MARS2 | ENTPD3 | 0.709458 | 3 | 0 | 3 |
| MARS2 | NSD1 | 0.709325 | 3 | 0 | 3 |
| MARS2 | TM9SF4 | 0.70876 | 3 | 0 | 3 |
For details and further investigation, click here
