| Full name: GC vitamin D binding protein | Alias Symbol: DBP|VDBP|hDBP | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 2638 | HGNC ID: HGNC:4187 | Ensembl Gene: ENSG00000145321 | OMIM ID: 139200 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GC | 2638 | 204965_at | 0.1270 | 0.5851 | |
| GSE20347 | GC | 2638 | 204965_at | -0.0091 | 0.8669 | |
| GSE23400 | GC | 2638 | 204965_at | -0.0746 | 0.0350 | |
| GSE26886 | GC | 2638 | 204965_at | 0.0323 | 0.7177 | |
| GSE29001 | GC | 2638 | 204965_at | -0.2161 | 0.1899 | |
| GSE38129 | GC | 2638 | 204965_at | -0.3988 | 0.1207 | |
| GSE45670 | GC | 2638 | 204965_at | 0.0705 | 0.3759 | |
| GSE53622 | GC | 2638 | 99196 | -0.4496 | 0.0923 | |
| GSE53624 | GC | 2638 | 99196 | -0.6768 | 0.0101 | |
| GSE63941 | GC | 2638 | 204965_at | 0.1114 | 0.3731 | |
| GSE77861 | GC | 2638 | 204965_at | 0.0772 | 0.3913 | |
| SRP133303 | GC | 2638 | RNAseq | 0.1878 | 0.5570 | |
| TCGA | GC | 2638 | RNAseq | -7.8369 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GC | 2638 | 1 | 11 | 18 | |
| GSE20123 | GC | 2638 | 1 | 11 | 18 | |
| GSE43470 | GC | 2638 | 0 | 13 | 30 | |
| GSE46452 | GC | 2638 | 2 | 35 | 22 | |
| GSE47630 | GC | 2638 | 1 | 19 | 20 | |
| GSE54993 | GC | 2638 | 7 | 0 | 63 | |
| GSE54994 | GC | 2638 | 1 | 9 | 43 | |
| GSE60625 | GC | 2638 | 0 | 0 | 11 | |
| GSE74703 | GC | 2638 | 0 | 11 | 25 | |
| GSE74704 | GC | 2638 | 1 | 6 | 13 | |
| TCGA | GC | 2638 | 17 | 27 | 52 |
Total number of gains: 31; Total number of losses: 142; Total Number of normals: 315.
Somatic mutations of GC:
Generating mutation plots.
Highly correlated genes for GC:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GC | CPA2 | 0.753265 | 5 | 0 | 5 |
| GC | ADAM21 | 0.711827 | 3 | 0 | 3 |
| GC | RRH | 0.704318 | 4 | 0 | 4 |
| GC | EPS8L3 | 0.694899 | 5 | 0 | 4 |
| GC | CHGA | 0.683052 | 5 | 0 | 5 |
| GC | OR2H2 | 0.681429 | 3 | 0 | 3 |
| GC | CLDN18 | 0.676598 | 7 | 0 | 7 |
| GC | PGC | 0.674801 | 6 | 0 | 4 |
| GC | TMED6 | 0.6747 | 3 | 0 | 3 |
| GC | FUT9 | 0.670074 | 6 | 0 | 4 |
| GC | FSTL4 | 0.668289 | 3 | 0 | 3 |
| GC | ACR | 0.664992 | 4 | 0 | 3 |
| GC | UGT2B15 | 0.662739 | 5 | 0 | 4 |
| GC | MUC6 | 0.662163 | 5 | 0 | 4 |
| GC | ATP4B | 0.661789 | 6 | 0 | 5 |
| GC | GRIK3 | 0.661541 | 3 | 0 | 3 |
| GC | NPY2R | 0.660948 | 3 | 0 | 3 |
| GC | PRODH2 | 0.659326 | 3 | 0 | 3 |
| GC | SLC22A2 | 0.657956 | 3 | 0 | 3 |
| GC | GKN1 | 0.653966 | 5 | 0 | 4 |
For details and further investigation, click here
