| Full name: glutamate ionotropic receptor kainate type subunit 3 | Alias Symbol: GluK3|GLUR7 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 2899 | HGNC ID: HGNC:4581 | Ensembl Gene: ENSG00000163873 | OMIM ID: 138243 |
| Drug and gene relationship at DGIdb | |||
GRIK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04724 | Glutamatergic synapse |
Expression of GRIK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRIK3 | 2899 | 230593_at | -0.1486 | 0.6219 | |
| GSE20347 | GRIK3 | 2899 | 207454_at | -0.0399 | 0.5296 | |
| GSE23400 | GRIK3 | 2899 | 207454_at | -0.1146 | 0.0043 | |
| GSE26886 | GRIK3 | 2899 | 207454_at | 0.0132 | 0.8797 | |
| GSE29001 | GRIK3 | 2899 | 207454_at | -0.1069 | 0.5953 | |
| GSE38129 | GRIK3 | 2899 | 207454_at | -0.0561 | 0.4866 | |
| GSE45670 | GRIK3 | 2899 | 230593_at | -0.4060 | 0.2692 | |
| GSE53622 | GRIK3 | 2899 | 38560 | -0.3468 | 0.0000 | |
| GSE53624 | GRIK3 | 2899 | 38560 | -1.7493 | 0.0000 | |
| GSE63941 | GRIK3 | 2899 | 207454_at | 0.0456 | 0.7832 | |
| GSE77861 | GRIK3 | 2899 | 207454_at | -0.0634 | 0.5121 | |
| GSE97050 | GRIK3 | 2899 | A_23_P149084 | -0.7928 | 0.1481 | |
| SRP133303 | GRIK3 | 2899 | RNAseq | -2.9500 | 0.0000 | |
| SRP159526 | GRIK3 | 2899 | RNAseq | -2.6218 | 0.0001 | |
| TCGA | GRIK3 | 2899 | RNAseq | -2.1359 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by GRIK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRIK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRIK3 | 2899 | 2 | 4 | 24 | |
| GSE20123 | GRIK3 | 2899 | 2 | 3 | 25 | |
| GSE43470 | GRIK3 | 2899 | 7 | 3 | 33 | |
| GSE46452 | GRIK3 | 2899 | 4 | 1 | 54 | |
| GSE47630 | GRIK3 | 2899 | 8 | 3 | 29 | |
| GSE54993 | GRIK3 | 2899 | 1 | 1 | 68 | |
| GSE54994 | GRIK3 | 2899 | 11 | 2 | 40 | |
| GSE60625 | GRIK3 | 2899 | 0 | 0 | 11 | |
| GSE74703 | GRIK3 | 2899 | 6 | 2 | 28 | |
| GSE74704 | GRIK3 | 2899 | 1 | 0 | 19 | |
| TCGA | GRIK3 | 2899 | 12 | 16 | 68 |
Total number of gains: 54; Total number of losses: 35; Total Number of normals: 399.
Somatic mutations of GRIK3:
Generating mutation plots.
Highly correlated genes for GRIK3:
Showing top 20/634 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRIK3 | PPP1R12C | 0.792291 | 3 | 0 | 3 |
| GRIK3 | C9orf24 | 0.774912 | 3 | 0 | 3 |
| GRIK3 | CACNA1H | 0.765237 | 4 | 0 | 4 |
| GRIK3 | CALCOCO1 | 0.738763 | 3 | 0 | 3 |
| GRIK3 | RNF167 | 0.7267 | 3 | 0 | 3 |
| GRIK3 | CDC42EP2 | 0.724179 | 3 | 0 | 3 |
| GRIK3 | TMEM8B | 0.707635 | 3 | 0 | 3 |
| GRIK3 | CCL25 | 0.707469 | 6 | 0 | 6 |
| GRIK3 | ADAMTS19 | 0.702855 | 3 | 0 | 3 |
| GRIK3 | ZNF491 | 0.702578 | 3 | 0 | 3 |
| GRIK3 | OR2H2 | 0.696365 | 5 | 0 | 5 |
| GRIK3 | TAF1 | 0.695105 | 3 | 0 | 3 |
| GRIK3 | CSN3 | 0.689233 | 4 | 0 | 4 |
| GRIK3 | INSC | 0.688687 | 3 | 0 | 3 |
| GRIK3 | GARNL3 | 0.686851 | 3 | 0 | 3 |
| GRIK3 | PAPPA2 | 0.682986 | 3 | 0 | 3 |
| GRIK3 | NOS1 | 0.682732 | 4 | 0 | 4 |
| GRIK3 | MC2R | 0.678294 | 4 | 0 | 4 |
| GRIK3 | MYOG | 0.67288 | 4 | 0 | 4 |
| GRIK3 | KIRREL2 | 0.671293 | 4 | 0 | 3 |
For details and further investigation, click here
