| Full name: GTP cyclohydrolase I feedback regulator | Alias Symbol: GFRP|HsT16933 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 2644 | HGNC ID: HGNC:4194 | Ensembl Gene: ENSG00000137880 | OMIM ID: 602437 |
| Drug and gene relationship at DGIdb | |||
Expression of GCHFR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCHFR | 2644 | 204867_at | -0.9868 | 0.1731 | |
| GSE20347 | GCHFR | 2644 | 204867_at | -1.8320 | 0.0000 | |
| GSE23400 | GCHFR | 2644 | 204867_at | -1.0003 | 0.0000 | |
| GSE26886 | GCHFR | 2644 | 204867_at | -1.2787 | 0.0000 | |
| GSE29001 | GCHFR | 2644 | 204867_at | -1.1103 | 0.0012 | |
| GSE38129 | GCHFR | 2644 | 204867_at | -1.3247 | 0.0000 | |
| GSE45670 | GCHFR | 2644 | 204867_at | -1.1696 | 0.0051 | |
| GSE63941 | GCHFR | 2644 | 204867_at | 0.7257 | 0.5941 | |
| GSE77861 | GCHFR | 2644 | 204867_at | -1.1038 | 0.0009 | |
| GSE97050 | GCHFR | 2644 | A_23_P77328 | -0.1615 | 0.8018 | |
| SRP007169 | GCHFR | 2644 | RNAseq | -2.9992 | 0.0000 | |
| SRP008496 | GCHFR | 2644 | RNAseq | -3.3122 | 0.0000 | |
| SRP064894 | GCHFR | 2644 | RNAseq | -1.8015 | 0.0002 | |
| SRP133303 | GCHFR | 2644 | RNAseq | -1.6800 | 0.0000 | |
| SRP159526 | GCHFR | 2644 | RNAseq | -1.7542 | 0.0004 | |
| SRP193095 | GCHFR | 2644 | RNAseq | -1.6197 | 0.0000 | |
| SRP219564 | GCHFR | 2644 | RNAseq | -2.1339 | 0.0155 | |
| TCGA | GCHFR | 2644 | RNAseq | -0.1979 | 0.1471 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by GCHFR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GCHFR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCHFR | 2644 | 3 | 6 | 21 | |
| GSE20123 | GCHFR | 2644 | 3 | 6 | 21 | |
| GSE43470 | GCHFR | 2644 | 4 | 6 | 33 | |
| GSE46452 | GCHFR | 2644 | 3 | 7 | 49 | |
| GSE47630 | GCHFR | 2644 | 8 | 11 | 21 | |
| GSE54993 | GCHFR | 2644 | 4 | 6 | 60 | |
| GSE54994 | GCHFR | 2644 | 5 | 7 | 41 | |
| GSE60625 | GCHFR | 2644 | 4 | 0 | 7 | |
| GSE74703 | GCHFR | 2644 | 4 | 5 | 27 | |
| GSE74704 | GCHFR | 2644 | 2 | 4 | 14 | |
| TCGA | GCHFR | 2644 | 11 | 18 | 67 |
Total number of gains: 51; Total number of losses: 76; Total Number of normals: 361.
Somatic mutations of GCHFR:
Generating mutation plots.
Highly correlated genes for GCHFR:
Showing top 20/860 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCHFR | ANXA9 | 0.84442 | 8 | 0 | 8 |
| GCHFR | AGFG2 | 0.824654 | 8 | 0 | 8 |
| GCHFR | C5orf66-AS1 | 0.818401 | 4 | 0 | 4 |
| GCHFR | FAM214A | 0.812086 | 4 | 0 | 4 |
| GCHFR | PRSS27 | 0.806879 | 5 | 0 | 5 |
| GCHFR | SMAGP | 0.803463 | 9 | 0 | 9 |
| GCHFR | PMM1 | 0.798792 | 9 | 0 | 9 |
| GCHFR | ACPP | 0.797796 | 9 | 0 | 9 |
| GCHFR | SASH1 | 0.796108 | 8 | 0 | 8 |
| GCHFR | TTC9 | 0.793345 | 9 | 0 | 9 |
| GCHFR | EPS8L2 | 0.791955 | 9 | 0 | 9 |
| GCHFR | SCNN1B | 0.790934 | 9 | 0 | 9 |
| GCHFR | EHD3 | 0.790487 | 8 | 0 | 8 |
| GCHFR | SPNS2 | 0.789588 | 4 | 0 | 4 |
| GCHFR | PSCA | 0.784952 | 8 | 0 | 8 |
| GCHFR | TRNP1 | 0.784571 | 4 | 0 | 4 |
| GCHFR | ABLIM1 | 0.784438 | 8 | 0 | 8 |
| GCHFR | IL36A | 0.783048 | 9 | 0 | 9 |
| GCHFR | FLG-AS1 | 0.780999 | 4 | 0 | 4 |
| GCHFR | ARHGAP27 | 0.780814 | 4 | 0 | 4 |
For details and further investigation, click here
