| Full name: interleukin 27 receptor subunit alpha | Alias Symbol: WSX-1|TCCR|CRL1|WSX1|zcytor1|IL-27R | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 9466 | HGNC ID: HGNC:17290 | Ensembl Gene: ENSG00000104998 | OMIM ID: 605350 |
| Drug and gene relationship at DGIdb | |||
IL27RA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL27RA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL27RA | 9466 | 205926_at | 0.5868 | 0.4080 | |
| GSE20347 | IL27RA | 9466 | 222062_at | 0.8773 | 0.0006 | |
| GSE23400 | IL27RA | 9466 | 205926_at | 0.2213 | 0.0000 | |
| GSE26886 | IL27RA | 9466 | 222062_at | 1.9170 | 0.0097 | |
| GSE29001 | IL27RA | 9466 | 222062_at | 1.3161 | 0.0166 | |
| GSE38129 | IL27RA | 9466 | 222062_at | 1.0672 | 0.0003 | |
| GSE45670 | IL27RA | 9466 | 222062_at | 0.8711 | 0.0329 | |
| GSE53622 | IL27RA | 9466 | 12639 | 0.6337 | 0.0000 | |
| GSE53624 | IL27RA | 9466 | 12639 | 0.4937 | 0.0000 | |
| GSE63941 | IL27RA | 9466 | 222062_at | 1.2499 | 0.0851 | |
| GSE77861 | IL27RA | 9466 | 205926_at | 0.2183 | 0.1278 | |
| GSE97050 | IL27RA | 9466 | A_23_P27606 | -0.1108 | 0.7108 | |
| SRP007169 | IL27RA | 9466 | RNAseq | 1.5226 | 0.0915 | |
| SRP008496 | IL27RA | 9466 | RNAseq | 0.6403 | 0.2211 | |
| SRP064894 | IL27RA | 9466 | RNAseq | 2.0081 | 0.0000 | |
| SRP133303 | IL27RA | 9466 | RNAseq | 0.4943 | 0.0713 | |
| SRP159526 | IL27RA | 9466 | RNAseq | 1.2784 | 0.0924 | |
| SRP193095 | IL27RA | 9466 | RNAseq | 0.9994 | 0.0000 | |
| SRP219564 | IL27RA | 9466 | RNAseq | 1.5166 | 0.0000 | |
| TCGA | IL27RA | 9466 | RNAseq | 0.5460 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by IL27RA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL27RA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL27RA | 9466 | 4 | 2 | 24 | |
| GSE20123 | IL27RA | 9466 | 3 | 1 | 26 | |
| GSE43470 | IL27RA | 9466 | 2 | 6 | 35 | |
| GSE46452 | IL27RA | 9466 | 47 | 1 | 11 | |
| GSE47630 | IL27RA | 9466 | 4 | 7 | 29 | |
| GSE54993 | IL27RA | 9466 | 15 | 4 | 51 | |
| GSE54994 | IL27RA | 9466 | 6 | 13 | 34 | |
| GSE60625 | IL27RA | 9466 | 9 | 0 | 2 | |
| GSE74703 | IL27RA | 9466 | 2 | 4 | 30 | |
| GSE74704 | IL27RA | 9466 | 0 | 1 | 19 | |
| TCGA | IL27RA | 9466 | 21 | 11 | 64 |
Total number of gains: 113; Total number of losses: 50; Total Number of normals: 325.
Somatic mutations of IL27RA:
Generating mutation plots.
Highly correlated genes for IL27RA:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL27RA | GGTLC1 | 0.782492 | 3 | 0 | 3 |
| IL27RA | REM2 | 0.721483 | 3 | 0 | 3 |
| IL27RA | CUL9 | 0.705817 | 3 | 0 | 3 |
| IL27RA | SALL3 | 0.692113 | 4 | 0 | 4 |
| IL27RA | MAST3 | 0.673419 | 5 | 0 | 4 |
| IL27RA | HOXC9 | 0.67106 | 3 | 0 | 3 |
| IL27RA | SHISA8 | 0.661035 | 4 | 0 | 3 |
| IL27RA | STOX1 | 0.653232 | 3 | 0 | 3 |
| IL27RA | SLC4A11 | 0.652977 | 4 | 0 | 3 |
| IL27RA | JAKMIP3 | 0.652531 | 3 | 0 | 3 |
| IL27RA | ZFAT | 0.646904 | 4 | 0 | 4 |
| IL27RA | ABI3 | 0.640234 | 3 | 0 | 3 |
| IL27RA | FBLN7 | 0.636117 | 4 | 0 | 3 |
| IL27RA | PHF21B | 0.63409 | 3 | 0 | 3 |
| IL27RA | RELB | 0.633075 | 10 | 0 | 8 |
| IL27RA | AKNA | 0.632776 | 4 | 0 | 3 |
| IL27RA | FERMT3 | 0.631177 | 3 | 0 | 3 |
| IL27RA | DFFB | 0.630781 | 6 | 0 | 6 |
| IL27RA | LRFN1 | 0.627655 | 4 | 0 | 3 |
| IL27RA | TENM3 | 0.624057 | 3 | 0 | 3 |
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