TMC8

 

Full name: transmembrane channel like 8 Alias Symbol: EVIN2
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 147138 HGNC ID: HGNC:20474 Ensembl Gene: ENSG00000167895 OMIM ID: 605829
Drug and gene relationship at DGIdb

 

Expression of TMC8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMC8 147138 227353_at 0.5469 0.4053
GSE26886 TMC8 147138 227353_at 1.0970 0.0018
GSE45670 TMC8 147138 227353_at 0.3661 0.2656
GSE53622 TMC8 147138 56460 -0.0581 0.6033
GSE53624 TMC8 147138 30490 0.3490 0.0006
GSE63941 TMC8 147138 227353_at 0.6000 0.2873
GSE77861 TMC8 147138 227353_at 0.6285 0.0062
GSE97050 TMC8 147138 A_24_P400573 1.2203 0.1323
SRP007169 TMC8 147138 RNAseq 1.4097 0.0734
SRP008496 TMC8 147138 RNAseq 0.5245 0.2026
SRP064894 TMC8 147138 RNAseq 0.7034 0.0135
SRP133303 TMC8 147138 RNAseq -0.2759 0.4288
SRP159526 TMC8 147138 RNAseq -0.8187 0.1892
SRP193095 TMC8 147138 RNAseq 0.6886 0.0154
SRP219564 TMC8 147138 RNAseq 0.4731 0.3985
TCGA TMC8 147138 RNAseq 0.3094 0.0201

Upregulated datasets: 1; Downregulated datasets: 0.  


 

Survival by TMC8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of TMC8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMC8 147138 5 4 21
GSE20123 TMC8 147138 5 4 21
GSE43470 TMC8 147138 3 4 36
GSE46452 TMC8 147138 33 0 26
GSE47630 TMC8 147138 8 1 31
GSE54993 TMC8 147138 2 5 63
GSE54994 TMC8 147138 10 4 39
GSE60625 TMC8 147138 6 0 5
GSE74703 TMC8 147138 3 2 31
GSE74704 TMC8 147138 4 3 13
TCGA TMC8 147138 31 8 57

Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.  


 

Somatic mutations of TMC8:

 

Generating mutation plots.

 

Highly correlated genes for TMC8:

 

Showing top 20/444 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMC8PLXND10.859573303
TMC8MYBL20.819709303
TMC8MSN0.818143303
TMC8TLR20.780063303
TMC8IL21R0.77752404
TMC8SDK10.768899303
TMC8CHST110.759357303
TMC8LHFPL20.757329303
TMC8ACOT70.75335303
TMC8CTHRC10.744527404
TMC8FSCN10.744225403
TMC8MFAP20.742668404
TMC8PLAUR0.740889303
TMC8RFC40.740462303
TMC8SAC3D10.737881303
TMC8MMP120.737834404
TMC8DTNB0.737012303
TMC8CHAF1A0.734191303
TMC8SNX100.725912504
TMC8CEBPB0.724569303

For details and further investigation, click here