| Full name: transmembrane channel like 8 | Alias Symbol: EVIN2 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 147138 | HGNC ID: HGNC:20474 | Ensembl Gene: ENSG00000167895 | OMIM ID: 605829 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMC8 | 147138 | 227353_at | 0.5469 | 0.4053 | |
| GSE26886 | TMC8 | 147138 | 227353_at | 1.0970 | 0.0018 | |
| GSE45670 | TMC8 | 147138 | 227353_at | 0.3661 | 0.2656 | |
| GSE53622 | TMC8 | 147138 | 56460 | -0.0581 | 0.6033 | |
| GSE53624 | TMC8 | 147138 | 30490 | 0.3490 | 0.0006 | |
| GSE63941 | TMC8 | 147138 | 227353_at | 0.6000 | 0.2873 | |
| GSE77861 | TMC8 | 147138 | 227353_at | 0.6285 | 0.0062 | |
| GSE97050 | TMC8 | 147138 | A_24_P400573 | 1.2203 | 0.1323 | |
| SRP007169 | TMC8 | 147138 | RNAseq | 1.4097 | 0.0734 | |
| SRP008496 | TMC8 | 147138 | RNAseq | 0.5245 | 0.2026 | |
| SRP064894 | TMC8 | 147138 | RNAseq | 0.7034 | 0.0135 | |
| SRP133303 | TMC8 | 147138 | RNAseq | -0.2759 | 0.4288 | |
| SRP159526 | TMC8 | 147138 | RNAseq | -0.8187 | 0.1892 | |
| SRP193095 | TMC8 | 147138 | RNAseq | 0.6886 | 0.0154 | |
| SRP219564 | TMC8 | 147138 | RNAseq | 0.4731 | 0.3985 | |
| TCGA | TMC8 | 147138 | RNAseq | 0.3094 | 0.0201 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TMC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC8 | 147138 | 5 | 4 | 21 | |
| GSE20123 | TMC8 | 147138 | 5 | 4 | 21 | |
| GSE43470 | TMC8 | 147138 | 3 | 4 | 36 | |
| GSE46452 | TMC8 | 147138 | 33 | 0 | 26 | |
| GSE47630 | TMC8 | 147138 | 8 | 1 | 31 | |
| GSE54993 | TMC8 | 147138 | 2 | 5 | 63 | |
| GSE54994 | TMC8 | 147138 | 10 | 4 | 39 | |
| GSE60625 | TMC8 | 147138 | 6 | 0 | 5 | |
| GSE74703 | TMC8 | 147138 | 3 | 2 | 31 | |
| GSE74704 | TMC8 | 147138 | 4 | 3 | 13 | |
| TCGA | TMC8 | 147138 | 31 | 8 | 57 |
Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.
Somatic mutations of TMC8:
Generating mutation plots.
Highly correlated genes for TMC8:
Showing top 20/444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC8 | PLXND1 | 0.859573 | 3 | 0 | 3 |
| TMC8 | MYBL2 | 0.819709 | 3 | 0 | 3 |
| TMC8 | MSN | 0.818143 | 3 | 0 | 3 |
| TMC8 | TLR2 | 0.780063 | 3 | 0 | 3 |
| TMC8 | IL21R | 0.77752 | 4 | 0 | 4 |
| TMC8 | SDK1 | 0.768899 | 3 | 0 | 3 |
| TMC8 | CHST11 | 0.759357 | 3 | 0 | 3 |
| TMC8 | LHFPL2 | 0.757329 | 3 | 0 | 3 |
| TMC8 | ACOT7 | 0.75335 | 3 | 0 | 3 |
| TMC8 | CTHRC1 | 0.744527 | 4 | 0 | 4 |
| TMC8 | FSCN1 | 0.744225 | 4 | 0 | 3 |
| TMC8 | MFAP2 | 0.742668 | 4 | 0 | 4 |
| TMC8 | PLAUR | 0.740889 | 3 | 0 | 3 |
| TMC8 | RFC4 | 0.740462 | 3 | 0 | 3 |
| TMC8 | SAC3D1 | 0.737881 | 3 | 0 | 3 |
| TMC8 | MMP12 | 0.737834 | 4 | 0 | 4 |
| TMC8 | DTNB | 0.737012 | 3 | 0 | 3 |
| TMC8 | CHAF1A | 0.734191 | 3 | 0 | 3 |
| TMC8 | SNX10 | 0.725912 | 5 | 0 | 4 |
| TMC8 | CEBPB | 0.724569 | 3 | 0 | 3 |
For details and further investigation, click here
