| Full name: gap junction protein alpha 5 | Alias Symbol: CX40 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 2702 | HGNC ID: HGNC:4279 | Ensembl Gene: ENSG00000265107 | OMIM ID: 121013 |
| Drug and gene relationship at DGIdb | |||
Expression of GJA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJA5 | 2702 | 226701_at | 0.4533 | 0.5554 | |
| GSE20347 | GJA5 | 2702 | 214466_at | -0.0194 | 0.8080 | |
| GSE23400 | GJA5 | 2702 | 214466_at | -0.0864 | 0.0007 | |
| GSE26886 | GJA5 | 2702 | 214466_at | -0.0436 | 0.7366 | |
| GSE29001 | GJA5 | 2702 | 214466_at | -0.2854 | 0.0364 | |
| GSE38129 | GJA5 | 2702 | 214466_at | -0.0798 | 0.3295 | |
| GSE45670 | GJA5 | 2702 | 226701_at | -0.4997 | 0.2655 | |
| GSE63941 | GJA5 | 2702 | 214466_at | 0.3439 | 0.1686 | |
| GSE77861 | GJA5 | 2702 | 214466_at | -0.0654 | 0.5200 | |
| GSE97050 | GJA5 | 2702 | A_23_P371729 | 0.7910 | 0.1450 | |
| SRP007169 | GJA5 | 2702 | RNAseq | 4.1672 | 0.0000 | |
| SRP008496 | GJA5 | 2702 | RNAseq | 5.3469 | 0.0000 | |
| SRP064894 | GJA5 | 2702 | RNAseq | 1.0627 | 0.0062 | |
| SRP133303 | GJA5 | 2702 | RNAseq | 1.0829 | 0.0008 | |
| SRP159526 | GJA5 | 2702 | RNAseq | 0.8942 | 0.0271 | |
| SRP219564 | GJA5 | 2702 | RNAseq | 0.5025 | 0.3323 | |
| TCGA | GJA5 | 2702 | RNAseq | -0.2768 | 0.1435 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by GJA5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GJA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJA5 | 2702 | 12 | 0 | 18 | |
| GSE20123 | GJA5 | 2702 | 12 | 0 | 18 | |
| GSE43470 | GJA5 | 2702 | 5 | 1 | 37 | |
| GSE46452 | GJA5 | 2702 | 2 | 1 | 56 | |
| GSE47630 | GJA5 | 2702 | 12 | 2 | 26 | |
| GSE54993 | GJA5 | 2702 | 0 | 2 | 68 | |
| GSE54994 | GJA5 | 2702 | 15 | 0 | 38 | |
| GSE60625 | GJA5 | 2702 | 0 | 0 | 11 | |
| GSE74703 | GJA5 | 2702 | 5 | 1 | 30 | |
| GSE74704 | GJA5 | 2702 | 6 | 0 | 14 | |
| TCGA | GJA5 | 2702 | 33 | 15 | 48 |
Total number of gains: 102; Total number of losses: 22; Total Number of normals: 364.
Somatic mutations of GJA5:
Generating mutation plots.
Highly correlated genes for GJA5:
Showing top 20/226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJA5 | PRKAR2A | 0.750122 | 3 | 0 | 3 |
| GJA5 | MUC6 | 0.745816 | 3 | 0 | 3 |
| GJA5 | RGS18 | 0.733161 | 3 | 0 | 3 |
| GJA5 | KCNG2 | 0.695054 | 3 | 0 | 3 |
| GJA5 | SIDT2 | 0.685303 | 3 | 0 | 3 |
| GJA5 | GLI2 | 0.676278 | 3 | 0 | 3 |
| GJA5 | DALRD3 | 0.676035 | 3 | 0 | 3 |
| GJA5 | ZNF689 | 0.675839 | 3 | 0 | 3 |
| GJA5 | ANKRD54 | 0.655283 | 3 | 0 | 3 |
| GJA5 | IL12RB1 | 0.651108 | 4 | 0 | 4 |
| GJA5 | CCIN | 0.648491 | 4 | 0 | 3 |
| GJA5 | APH1B | 0.642408 | 3 | 0 | 3 |
| GJA5 | MTHFR | 0.641327 | 4 | 0 | 3 |
| GJA5 | TPMT | 0.63945 | 3 | 0 | 3 |
| GJA5 | XPNPEP2 | 0.637326 | 4 | 0 | 4 |
| GJA5 | MRPL41 | 0.636527 | 4 | 0 | 3 |
| GJA5 | TMEM214 | 0.632084 | 4 | 0 | 3 |
| GJA5 | MKS1 | 0.629059 | 4 | 0 | 3 |
| GJA5 | PRKACG | 0.627452 | 3 | 0 | 3 |
| GJA5 | SIK2 | 0.622842 | 3 | 0 | 3 |
For details and further investigation, click here
