IL12RB1

 

Full name: interleukin 12 receptor subunit beta 1 Alias Symbol: CD212
Type: protein-coding gene Cytoband: 19p13.11
Entrez ID: 3594 HGNC ID: HGNC:5971 Ensembl Gene: ENSG00000096996 OMIM ID: 601604
Drug and gene relationship at DGIdb

 

IL12RB1 involved pathways:

KEGG pathway Description View
hsa04630Jak-STAT signaling pathway
hsa05321Inflammatory bowel disease (IBD)

 

Expression of IL12RB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL12RB1 3594 1552584_at 0.3164 0.7558
GSE20347 IL12RB1 3594 206890_at -0.0931 0.3483
GSE23400 IL12RB1 3594 206890_at -0.1678 0.0000
GSE26886 IL12RB1 3594 239522_at 0.2136 0.1477
GSE29001 IL12RB1 3594 206890_at -0.2626 0.0502
GSE38129 IL12RB1 3594 206890_at -0.0792 0.4102
GSE45670 IL12RB1 3594 1552584_at 0.1682 0.4890
GSE53622 IL12RB1 3594 14320 0.5009 0.0000
GSE53624 IL12RB1 3594 14320 0.4472 0.0000
GSE63941 IL12RB1 3594 239522_at 0.3193 0.0511
GSE77861 IL12RB1 3594 206890_at -0.4019 0.0029
GSE97050 IL12RB1 3594 A_23_P399156 0.7931 0.1541
SRP007169 IL12RB1 3594 RNAseq 0.2919 0.6185
SRP064894 IL12RB1 3594 RNAseq 0.1351 0.4352
SRP133303 IL12RB1 3594 RNAseq 0.0021 0.9868
SRP159526 IL12RB1 3594 RNAseq -0.3225 0.6403
SRP193095 IL12RB1 3594 RNAseq 0.1529 0.3357
SRP219564 IL12RB1 3594 RNAseq 0.8318 0.1563
TCGA IL12RB1 3594 RNAseq 0.6572 0.0237

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IL12RB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL12RB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL12RB1 3594 4 4 22
GSE20123 IL12RB1 3594 3 2 25
GSE43470 IL12RB1 3594 2 6 35
GSE46452 IL12RB1 3594 47 1 11
GSE47630 IL12RB1 3594 4 8 28
GSE54993 IL12RB1 3594 15 4 51
GSE54994 IL12RB1 3594 6 13 34
GSE60625 IL12RB1 3594 9 0 2
GSE74703 IL12RB1 3594 2 4 30
GSE74704 IL12RB1 3594 0 2 18
TCGA IL12RB1 3594 17 9 70

Total number of gains: 109; Total number of losses: 53; Total Number of normals: 326.  

 

Somatic mutations of IL12RB1:

 

Generating mutation plots.

 

Highly correlated genes for IL12RB1:

 

Showing top 20/600 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL12RB1LCK0.782269505
IL12RB1LCP20.773363505
IL12RB1LAIR10.771616606
IL12RB1IL2RB0.763222605
IL12RB1PSMB8-AS10.748446404
IL12RB1IL2RG0.719645706
IL12RB1BTN2A20.716411303
IL12RB1MANF0.712635303
IL12RB1MILR10.700749404
IL12RB1CD3D0.697915807
IL12RB1SNX200.692182605
IL12RB1PDYN0.690229606
IL12RB1PIK3R50.6893761009
IL12RB1G6PC20.6877505
IL12RB1HAVCR20.683992505
IL12RB1GNGT20.678279505
IL12RB1GPR1710.677119605
IL12RB1PTPN70.676912706
IL12RB1CD50.673915908
IL12RB1MAMDC40.67323303

For details and further investigation, click here