| Full name: thiopurine S-methyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 7172 | HGNC ID: HGNC:12014 | Ensembl Gene: ENSG00000137364 | OMIM ID: 187680 |
| Drug and gene relationship at DGIdb | |||
Expression of TPMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPMT | 7172 | 203672_x_at | 0.1127 | 0.7531 | |
| GSE20347 | TPMT | 7172 | 203672_x_at | -0.2819 | 0.0349 | |
| GSE23400 | TPMT | 7172 | 203672_x_at | -0.0026 | 0.9677 | |
| GSE26886 | TPMT | 7172 | 203672_x_at | 0.0283 | 0.9280 | |
| GSE29001 | TPMT | 7172 | 203672_x_at | -0.3473 | 0.0525 | |
| GSE38129 | TPMT | 7172 | 203672_x_at | -0.2761 | 0.0224 | |
| GSE45670 | TPMT | 7172 | 203671_at | 0.1439 | 0.4405 | |
| GSE53622 | TPMT | 7172 | 37843 | -0.1406 | 0.2764 | |
| GSE53624 | TPMT | 7172 | 37843 | 0.0112 | 0.8917 | |
| GSE63941 | TPMT | 7172 | 203672_x_at | 0.9735 | 0.0188 | |
| GSE77861 | TPMT | 7172 | 203671_at | 0.2566 | 0.2628 | |
| GSE97050 | TPMT | 7172 | A_33_P3317321 | 0.1690 | 0.4870 | |
| SRP007169 | TPMT | 7172 | RNAseq | 0.2424 | 0.5342 | |
| SRP008496 | TPMT | 7172 | RNAseq | 0.3478 | 0.1834 | |
| SRP064894 | TPMT | 7172 | RNAseq | 0.0925 | 0.6487 | |
| SRP133303 | TPMT | 7172 | RNAseq | 0.2870 | 0.1412 | |
| SRP159526 | TPMT | 7172 | RNAseq | -0.1351 | 0.6242 | |
| SRP193095 | TPMT | 7172 | RNAseq | -0.5846 | 0.0037 | |
| SRP219564 | TPMT | 7172 | RNAseq | -0.2327 | 0.4437 | |
| TCGA | TPMT | 7172 | RNAseq | 0.0063 | 0.9207 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TPMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPMT | 7172 | 2 | 5 | 23 | |
| GSE20123 | TPMT | 7172 | 2 | 5 | 23 | |
| GSE43470 | TPMT | 7172 | 9 | 0 | 34 | |
| GSE46452 | TPMT | 7172 | 1 | 10 | 48 | |
| GSE47630 | TPMT | 7172 | 7 | 7 | 26 | |
| GSE54993 | TPMT | 7172 | 1 | 1 | 68 | |
| GSE54994 | TPMT | 7172 | 10 | 4 | 39 | |
| GSE60625 | TPMT | 7172 | 0 | 1 | 10 | |
| GSE74703 | TPMT | 7172 | 8 | 0 | 28 | |
| GSE74704 | TPMT | 7172 | 1 | 2 | 17 | |
| TCGA | TPMT | 7172 | 16 | 26 | 54 |
Total number of gains: 57; Total number of losses: 61; Total Number of normals: 370.
Somatic mutations of TPMT:
Generating mutation plots.
Highly correlated genes for TPMT:
Showing top 20/182 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPMT | EIF2AK4 | 0.778055 | 3 | 0 | 3 |
| TPMT | RBCK1 | 0.772445 | 3 | 0 | 3 |
| TPMT | GSR | 0.765291 | 3 | 0 | 3 |
| TPMT | CPSF3 | 0.762002 | 3 | 0 | 3 |
| TPMT | FAM199X | 0.757009 | 3 | 0 | 3 |
| TPMT | SLC4A1AP | 0.743585 | 3 | 0 | 3 |
| TPMT | PLEKHA2 | 0.732365 | 3 | 0 | 3 |
| TPMT | MFN1 | 0.730106 | 3 | 0 | 3 |
| TPMT | PRELID1 | 0.726522 | 3 | 0 | 3 |
| TPMT | NARS2 | 0.723511 | 3 | 0 | 3 |
| TPMT | SPAST | 0.721886 | 3 | 0 | 3 |
| TPMT | RC3H2 | 0.720671 | 3 | 0 | 3 |
| TPMT | NAV2 | 0.718666 | 3 | 0 | 3 |
| TPMT | CMIP | 0.711049 | 3 | 0 | 3 |
| TPMT | KDELR2 | 0.707303 | 3 | 0 | 3 |
| TPMT | ACER3 | 0.702525 | 3 | 0 | 3 |
| TPMT | SFT2D3 | 0.693438 | 3 | 0 | 3 |
| TPMT | PIGW | 0.691645 | 3 | 0 | 3 |
| TPMT | TMEM17 | 0.690339 | 4 | 0 | 3 |
| TPMT | MSH2 | 0.687661 | 3 | 0 | 3 |
For details and further investigation, click here
