| Full name: gap junction protein beta 3 | Alias Symbol: CX31 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 2707 | HGNC ID: HGNC:4285 | Ensembl Gene: ENSG00000188910 | OMIM ID: 603324 |
| Drug and gene relationship at DGIdb | |||
Expression of GJB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJB3 | 2707 | 205490_x_at | 0.0123 | 0.9908 | |
| GSE20347 | GJB3 | 2707 | 205490_x_at | -0.4604 | 0.0312 | |
| GSE23400 | GJB3 | 2707 | 205490_x_at | 0.1880 | 0.0606 | |
| GSE26886 | GJB3 | 2707 | 205490_x_at | 0.0575 | 0.8331 | |
| GSE29001 | GJB3 | 2707 | 205490_x_at | -0.1200 | 0.6525 | |
| GSE38129 | GJB3 | 2707 | 205490_x_at | 0.1633 | 0.6904 | |
| GSE45670 | GJB3 | 2707 | 205490_x_at | 0.3386 | 0.1188 | |
| GSE53622 | GJB3 | 2707 | 4565 | 0.1967 | 0.6006 | |
| GSE53624 | GJB3 | 2707 | 4565 | -0.1819 | 0.2538 | |
| GSE63941 | GJB3 | 2707 | 205490_x_at | 2.7018 | 0.0018 | |
| GSE77861 | GJB3 | 2707 | 205490_x_at | 0.0595 | 0.8462 | |
| GSE97050 | GJB3 | 2707 | A_24_P379233 | 0.5361 | 0.5830 | |
| SRP007169 | GJB3 | 2707 | RNAseq | -0.8592 | 0.0532 | |
| SRP008496 | GJB3 | 2707 | RNAseq | -1.1518 | 0.0000 | |
| SRP064894 | GJB3 | 2707 | RNAseq | 0.3382 | 0.4356 | |
| SRP133303 | GJB3 | 2707 | RNAseq | 0.0501 | 0.8536 | |
| SRP159526 | GJB3 | 2707 | RNAseq | -0.5368 | 0.2385 | |
| SRP193095 | GJB3 | 2707 | RNAseq | -0.1289 | 0.6607 | |
| SRP219564 | GJB3 | 2707 | RNAseq | -0.4606 | 0.6670 | |
| TCGA | GJB3 | 2707 | RNAseq | 0.9742 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by GJB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJB3 | 2707 | 2 | 5 | 23 | |
| GSE20123 | GJB3 | 2707 | 2 | 4 | 24 | |
| GSE43470 | GJB3 | 2707 | 6 | 2 | 35 | |
| GSE46452 | GJB3 | 2707 | 4 | 1 | 54 | |
| GSE47630 | GJB3 | 2707 | 8 | 3 | 29 | |
| GSE54993 | GJB3 | 2707 | 1 | 1 | 68 | |
| GSE54994 | GJB3 | 2707 | 11 | 2 | 40 | |
| GSE60625 | GJB3 | 2707 | 0 | 0 | 11 | |
| GSE74703 | GJB3 | 2707 | 5 | 1 | 30 | |
| GSE74704 | GJB3 | 2707 | 1 | 0 | 19 | |
| TCGA | GJB3 | 2707 | 13 | 18 | 65 |
Total number of gains: 53; Total number of losses: 37; Total Number of normals: 398.
Somatic mutations of GJB3:
Generating mutation plots.
Highly correlated genes for GJB3:
Showing top 20/632 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJB3 | GJB5 | 0.739482 | 12 | 0 | 12 |
| GJB3 | TPRKB | 0.701136 | 3 | 0 | 3 |
| GJB3 | MACC1 | 0.698062 | 3 | 0 | 3 |
| GJB3 | S100A2 | 0.696345 | 11 | 0 | 11 |
| GJB3 | CERS3 | 0.693966 | 4 | 0 | 3 |
| GJB3 | MAP7 | 0.690865 | 7 | 0 | 6 |
| GJB3 | ISY1 | 0.690596 | 3 | 0 | 3 |
| GJB3 | DUSP7 | 0.688145 | 10 | 0 | 8 |
| GJB3 | ELOVL1 | 0.687821 | 4 | 0 | 4 |
| GJB3 | SLC25A10 | 0.685193 | 5 | 0 | 5 |
| GJB3 | ANKZF1 | 0.683735 | 3 | 0 | 3 |
| GJB3 | F2RL1 | 0.677566 | 7 | 0 | 6 |
| GJB3 | BNC1 | 0.67299 | 9 | 0 | 8 |
| GJB3 | CBLC | 0.668563 | 10 | 0 | 8 |
| GJB3 | PRRG4 | 0.666465 | 9 | 0 | 7 |
| GJB3 | EGFL6 | 0.666124 | 3 | 0 | 3 |
| GJB3 | GNA15 | 0.66393 | 10 | 0 | 9 |
| GJB3 | WNT10A | 0.662666 | 4 | 0 | 3 |
| GJB3 | HOOK2 | 0.662543 | 4 | 0 | 4 |
| GJB3 | NDUFA9 | 0.659418 | 3 | 0 | 3 |
For details and further investigation, click here
