| Full name: gap junction protein beta 5 | Alias Symbol: CX31.1 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 2709 | HGNC ID: HGNC:4287 | Ensembl Gene: ENSG00000189280 | OMIM ID: 604493 |
| Drug and gene relationship at DGIdb | |||
Expression of GJB5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJB5 | 2709 | 206156_at | -0.6670 | 0.4048 | |
| GSE20347 | GJB5 | 2709 | 206156_at | -1.0109 | 0.0000 | |
| GSE23400 | GJB5 | 2709 | 206156_at | -0.3870 | 0.0007 | |
| GSE26886 | GJB5 | 2709 | 206156_at | -1.9050 | 0.0000 | |
| GSE29001 | GJB5 | 2709 | 206156_at | -0.6757 | 0.0750 | |
| GSE38129 | GJB5 | 2709 | 206156_at | -0.2849 | 0.5085 | |
| GSE45670 | GJB5 | 2709 | 206156_at | 0.1239 | 0.5590 | |
| GSE53622 | GJB5 | 2709 | 78962 | -0.0934 | 0.8021 | |
| GSE53624 | GJB5 | 2709 | 78962 | -0.6154 | 0.0000 | |
| GSE63941 | GJB5 | 2709 | 206156_at | 3.0034 | 0.0005 | |
| GSE77861 | GJB5 | 2709 | 206156_at | -0.4327 | 0.1172 | |
| GSE97050 | GJB5 | 2709 | A_23_P35293 | 1.4580 | 0.3889 | |
| SRP007169 | GJB5 | 2709 | RNAseq | -1.6721 | 0.0010 | |
| SRP008496 | GJB5 | 2709 | RNAseq | -1.9137 | 0.0000 | |
| SRP064894 | GJB5 | 2709 | RNAseq | -0.7630 | 0.0768 | |
| SRP133303 | GJB5 | 2709 | RNAseq | -0.7853 | 0.0037 | |
| SRP159526 | GJB5 | 2709 | RNAseq | -0.9143 | 0.0575 | |
| SRP219564 | GJB5 | 2709 | RNAseq | -1.2840 | 0.3042 | |
| TCGA | GJB5 | 2709 | RNAseq | 1.9823 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 4.
Survival by GJB5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJB5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJB5 | 2709 | 2 | 5 | 23 | |
| GSE20123 | GJB5 | 2709 | 2 | 4 | 24 | |
| GSE43470 | GJB5 | 2709 | 6 | 2 | 35 | |
| GSE46452 | GJB5 | 2709 | 4 | 1 | 54 | |
| GSE47630 | GJB5 | 2709 | 8 | 3 | 29 | |
| GSE54993 | GJB5 | 2709 | 1 | 1 | 68 | |
| GSE54994 | GJB5 | 2709 | 11 | 2 | 40 | |
| GSE60625 | GJB5 | 2709 | 0 | 0 | 11 | |
| GSE74703 | GJB5 | 2709 | 5 | 1 | 30 | |
| GSE74704 | GJB5 | 2709 | 1 | 0 | 19 | |
| TCGA | GJB5 | 2709 | 13 | 18 | 65 |
Total number of gains: 53; Total number of losses: 37; Total Number of normals: 398.
Somatic mutations of GJB5:
Generating mutation plots.
Highly correlated genes for GJB5:
Showing top 20/983 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJB5 | TRIM29 | 0.740346 | 11 | 0 | 10 |
| GJB5 | GJB3 | 0.739482 | 12 | 0 | 12 |
| GJB5 | GRHL2 | 0.736878 | 5 | 0 | 5 |
| GJB5 | KRT6C | 0.736675 | 4 | 0 | 3 |
| GJB5 | CST11 | 0.733504 | 3 | 0 | 3 |
| GJB5 | LAD1 | 0.724079 | 11 | 0 | 9 |
| GJB5 | LYPD3 | 0.723833 | 13 | 0 | 12 |
| GJB5 | LPAR5 | 0.714999 | 7 | 0 | 7 |
| GJB5 | FAM83C | 0.712809 | 5 | 0 | 4 |
| GJB5 | C3orf38 | 0.71229 | 3 | 0 | 3 |
| GJB5 | FAM83H | 0.710647 | 5 | 0 | 4 |
| GJB5 | SERPINB5 | 0.710282 | 12 | 0 | 12 |
| GJB5 | KRT80 | 0.703411 | 6 | 0 | 6 |
| GJB5 | S100A11 | 0.703338 | 12 | 0 | 10 |
| GJB5 | S100A16 | 0.701126 | 7 | 0 | 6 |
| GJB5 | PPP1R13L | 0.700222 | 10 | 0 | 9 |
| GJB5 | DSG3 | 0.699615 | 12 | 0 | 11 |
| GJB5 | FGFBP1 | 0.699397 | 10 | 0 | 9 |
| GJB5 | ZCCHC9 | 0.698012 | 3 | 0 | 3 |
| GJB5 | ATG7 | 0.693924 | 6 | 0 | 6 |
For details and further investigation, click here
