| Full name: collagen type I alpha 1 chain | Alias Symbol: OI4 | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 1277 | HGNC ID: HGNC:2197 | Ensembl Gene: ENSG00000108821 | OMIM ID: 120150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
COL1A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04611 | Platelet activation | |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of COL1A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL1A1 | 1277 | 1556499_s_at | 1.4921 | 0.0835 | |
| GSE20347 | COL1A1 | 1277 | 202310_s_at | 3.2588 | 0.0000 | |
| GSE23400 | COL1A1 | 1277 | 202310_s_at | 3.1543 | 0.0000 | |
| GSE26886 | COL1A1 | 1277 | 1556499_s_at | 4.0995 | 0.0000 | |
| GSE29001 | COL1A1 | 1277 | 217430_x_at | -0.0427 | 0.8619 | |
| GSE38129 | COL1A1 | 1277 | 202310_s_at | 3.2858 | 0.0000 | |
| GSE45670 | COL1A1 | 1277 | 1556499_s_at | 1.1266 | 0.0580 | |
| GSE53622 | COL1A1 | 1277 | 41447 | 3.7893 | 0.0000 | |
| GSE53624 | COL1A1 | 1277 | 41447 | 3.7499 | 0.0000 | |
| GSE63941 | COL1A1 | 1277 | 1556499_s_at | -5.2396 | 0.0006 | |
| GSE77861 | COL1A1 | 1277 | 1556499_s_at | 3.6558 | 0.0110 | |
| GSE97050 | COL1A1 | 1277 | A_33_P3304668 | 2.7159 | 0.0454 | |
| SRP007169 | COL1A1 | 1277 | RNAseq | 8.1841 | 0.0000 | |
| SRP008496 | COL1A1 | 1277 | RNAseq | 8.4017 | 0.0000 | |
| SRP064894 | COL1A1 | 1277 | RNAseq | 3.7147 | 0.0000 | |
| SRP133303 | COL1A1 | 1277 | RNAseq | 4.6998 | 0.0000 | |
| SRP159526 | COL1A1 | 1277 | RNAseq | 2.4826 | 0.0000 | |
| SRP193095 | COL1A1 | 1277 | RNAseq | 5.2484 | 0.0000 | |
| SRP219564 | COL1A1 | 1277 | RNAseq | 4.1079 | 0.0000 | |
| TCGA | COL1A1 | 1277 | RNAseq | 0.5588 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 1.
Survival by COL1A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL1A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL1A1 | 1277 | 5 | 2 | 23 | |
| GSE20123 | COL1A1 | 1277 | 5 | 2 | 23 | |
| GSE43470 | COL1A1 | 1277 | 3 | 2 | 38 | |
| GSE46452 | COL1A1 | 1277 | 32 | 0 | 27 | |
| GSE47630 | COL1A1 | 1277 | 9 | 0 | 31 | |
| GSE54993 | COL1A1 | 1277 | 2 | 4 | 64 | |
| GSE54994 | COL1A1 | 1277 | 9 | 6 | 38 | |
| GSE60625 | COL1A1 | 1277 | 4 | 0 | 7 | |
| GSE74703 | COL1A1 | 1277 | 3 | 2 | 31 | |
| GSE74704 | COL1A1 | 1277 | 4 | 1 | 15 | |
| TCGA | COL1A1 | 1277 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of COL1A1:
Generating mutation plots.
Highly correlated genes for COL1A1:
Showing top 20/975 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL1A1 | COL3A1 | 0.933579 | 12 | 0 | 12 |
| COL1A1 | COL5A2 | 0.89789 | 12 | 0 | 12 |
| COL1A1 | COL1A2 | 0.896366 | 12 | 0 | 12 |
| COL1A1 | COL6A3 | 0.876682 | 12 | 0 | 12 |
| COL1A1 | COL5A1 | 0.866145 | 12 | 0 | 12 |
| COL1A1 | CTHRC1 | 0.854642 | 9 | 0 | 9 |
| COL1A1 | VCAN | 0.853449 | 12 | 0 | 12 |
| COL1A1 | BGN | 0.833333 | 12 | 0 | 12 |
| COL1A1 | SPARC | 0.833224 | 12 | 0 | 11 |
| COL1A1 | FAP | 0.819773 | 10 | 0 | 10 |
| COL1A1 | THY1 | 0.81406 | 12 | 0 | 12 |
| COL1A1 | ADAMTS12 | 0.810254 | 9 | 0 | 9 |
| COL1A1 | INHBA | 0.801802 | 11 | 0 | 11 |
| COL1A1 | LEPR | 0.792823 | 3 | 0 | 3 |
| COL1A1 | SULF1 | 0.783613 | 12 | 0 | 12 |
| COL1A1 | LOXL2 | 0.783153 | 11 | 0 | 11 |
| COL1A1 | MFAP2 | 0.780078 | 12 | 0 | 11 |
| COL1A1 | SPP1 | 0.778566 | 10 | 0 | 8 |
| COL1A1 | MMP1 | 0.776445 | 12 | 0 | 11 |
| COL1A1 | COL10A1 | 0.765381 | 11 | 0 | 10 |
For details and further investigation, click here
