PDE4B

 

Full name: phosphodiesterase 4B Alias Symbol: 
Type: protein-coding gene Cytoband: 1p31.3
Entrez ID: 5142 HGNC ID: HGNC:8781 Ensembl Gene: ENSG00000184588 OMIM ID: 600127
Drug and gene relationship at DGIdb

 

PDE4B involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway

 

Expression of PDE4B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDE4B 5142 203708_at -0.0465 0.9798
GSE20347 PDE4B 5142 203708_at 0.4311 0.3088
GSE23400 PDE4B 5142 211302_s_at 0.1653 0.0629
GSE26886 PDE4B 5142 203708_at 0.7107 0.1857
GSE29001 PDE4B 5142 203708_at 0.5087 0.4333
GSE38129 PDE4B 5142 203708_at 0.2123 0.5884
GSE45670 PDE4B 5142 203708_at -0.6902 0.1636
GSE53622 PDE4B 5142 17859 0.2289 0.2254
GSE53624 PDE4B 5142 17859 -0.0578 0.7595
GSE63941 PDE4B 5142 203708_at -3.8750 0.0038
GSE77861 PDE4B 5142 203708_at 0.1701 0.4914
GSE97050 PDE4B 5142 A_23_P74278 0.6115 0.1657
SRP007169 PDE4B 5142 RNAseq 1.1624 0.0373
SRP008496 PDE4B 5142 RNAseq 1.3904 0.0026
SRP064894 PDE4B 5142 RNAseq 0.5994 0.0985
SRP133303 PDE4B 5142 RNAseq 0.7664 0.0216
SRP159526 PDE4B 5142 RNAseq 1.4761 0.0086
SRP193095 PDE4B 5142 RNAseq 1.9293 0.0000
SRP219564 PDE4B 5142 RNAseq 1.0647 0.0035
TCGA PDE4B 5142 RNAseq -0.0180 0.9037

Upregulated datasets: 5; Downregulated datasets: 1.  

 

Survival by PDE4B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDE4B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDE4B 5142 2 6 22
GSE20123 PDE4B 5142 2 5 23
GSE43470 PDE4B 5142 4 2 37
GSE46452 PDE4B 5142 0 1 58
GSE47630 PDE4B 5142 8 5 27
GSE54993 PDE4B 5142 0 0 70
GSE54994 PDE4B 5142 6 4 43
GSE60625 PDE4B 5142 0 0 11
GSE74703 PDE4B 5142 3 2 31
GSE74704 PDE4B 5142 1 2 17
TCGA PDE4B 5142 9 21 66

Total number of gains: 35; Total number of losses: 48; Total Number of normals: 405.  

 

Somatic mutations of PDE4B:

 

Generating mutation plots.

 

Highly correlated genes for PDE4B:

 

Showing top 20/684 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDE4BGNGT20.812344303
PDE4BGAPT0.747703303
PDE4BPIGS0.742858303
PDE4BSLAMF60.736332303
PDE4BPARVG0.735614303
PDE4BZNF5660.73126303
PDE4BBTLA0.73094303
PDE4BCLEC14A0.730643404
PDE4BTNFSF130.715971303
PDE4BCCL220.711467303
PDE4BCCL110.70682606
PDE4BCCR20.703616403
PDE4BGBGT10.698175403
PDE4BZNF180.69757303
PDE4BPREX10.694298303
PDE4BCX3CR10.688309303
PDE4BLRRK10.688158404
PDE4BUNC5C0.687869404
PDE4BANPEP0.687699403
PDE4BTRABD2A0.686969303

For details and further investigation, click here