| Full name: growth differentiation factor 6 | Alias Symbol: BMP13|KFS|KFS1 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 392255 | HGNC ID: HGNC:4221 | Ensembl Gene: ENSG00000156466 | OMIM ID: 601147 |
| Drug and gene relationship at DGIdb | |||
GDF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of GDF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | GDF6 | 392255 | 116455 | 0.1050 | 0.6463 | |
| GSE53624 | GDF6 | 392255 | 116455 | 0.5797 | 0.0131 | |
| GSE97050 | GDF6 | 392255 | A_32_P140489 | 0.2457 | 0.3443 | |
| SRP133303 | GDF6 | 392255 | RNAseq | 0.6912 | 0.0943 | |
| SRP219564 | GDF6 | 392255 | RNAseq | 2.3474 | 0.0017 | |
| TCGA | GDF6 | 392255 | RNAseq | -0.0568 | 0.8824 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GDF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GDF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDF6 | 392255 | 16 | 0 | 14 | |
| GSE20123 | GDF6 | 392255 | 17 | 0 | 13 | |
| GSE43470 | GDF6 | 392255 | 21 | 1 | 21 | |
| GSE46452 | GDF6 | 392255 | 23 | 0 | 36 | |
| GSE47630 | GDF6 | 392255 | 24 | 0 | 16 | |
| GSE54993 | GDF6 | 392255 | 0 | 20 | 50 | |
| GSE54994 | GDF6 | 392255 | 35 | 1 | 17 | |
| GSE60625 | GDF6 | 392255 | 0 | 4 | 7 | |
| GSE74703 | GDF6 | 392255 | 18 | 1 | 17 | |
| GSE74704 | GDF6 | 392255 | 12 | 0 | 8 | |
| TCGA | GDF6 | 392255 | 56 | 1 | 39 |
Total number of gains: 222; Total number of losses: 28; Total Number of normals: 238.
Somatic mutations of GDF6:
Generating mutation plots.
Highly correlated genes for GDF6:
Showing top 20/31 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDF6 | GLT8D2 | 0.748483 | 3 | 0 | 3 |
| GDF6 | LRRC17 | 0.745346 | 3 | 0 | 3 |
| GDF6 | GPC6 | 0.741577 | 3 | 0 | 3 |
| GDF6 | TGFB3 | 0.736062 | 3 | 0 | 3 |
| GDF6 | SPON1 | 0.718007 | 3 | 0 | 3 |
| GDF6 | OLFML3 | 0.715784 | 3 | 0 | 3 |
| GDF6 | PDGFRL | 0.708971 | 3 | 0 | 3 |
| GDF6 | DACT1 | 0.70716 | 3 | 0 | 3 |
| GDF6 | EFEMP2 | 0.704161 | 3 | 0 | 3 |
| GDF6 | OLFML1 | 0.699563 | 3 | 0 | 3 |
| GDF6 | CNRIP1 | 0.696368 | 3 | 0 | 3 |
| GDF6 | PTGER3 | 0.695239 | 3 | 0 | 3 |
| GDF6 | BICC1 | 0.682835 | 3 | 0 | 3 |
| GDF6 | HIC1 | 0.678522 | 3 | 0 | 3 |
| GDF6 | MAN1A1 | 0.67713 | 3 | 0 | 3 |
| GDF6 | NLRP3 | 0.675189 | 3 | 0 | 3 |
| GDF6 | MRAS | 0.674845 | 3 | 0 | 3 |
| GDF6 | PMP22 | 0.672997 | 3 | 0 | 3 |
| GDF6 | UNC5C | 0.671639 | 3 | 0 | 3 |
| GDF6 | EDA2R | 0.663818 | 3 | 0 | 3 |
For details and further investigation, click here
