| Full name: tripeptidyl peptidase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 1200 | HGNC ID: HGNC:2073 | Ensembl Gene: ENSG00000166340 | OMIM ID: 607998 |
| Drug and gene relationship at DGIdb | |||
Expression of TPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPP1 | 1200 | 200743_s_at | -0.1723 | 0.5563 | |
| GSE20347 | TPP1 | 1200 | 200743_s_at | -0.0195 | 0.8925 | |
| GSE23400 | TPP1 | 1200 | 200743_s_at | 0.3073 | 0.0000 | |
| GSE26886 | TPP1 | 1200 | 200743_s_at | -0.0078 | 0.9754 | |
| GSE29001 | TPP1 | 1200 | 200742_s_at | 0.2251 | 0.2799 | |
| GSE38129 | TPP1 | 1200 | 200743_s_at | -0.0165 | 0.9200 | |
| GSE45670 | TPP1 | 1200 | 200743_s_at | 0.2007 | 0.2881 | |
| GSE53622 | TPP1 | 1200 | 59841 | 0.3219 | 0.0000 | |
| GSE53624 | TPP1 | 1200 | 59841 | 0.4818 | 0.0000 | |
| GSE63941 | TPP1 | 1200 | 200743_s_at | -1.2095 | 0.0887 | |
| GSE77861 | TPP1 | 1200 | 200743_s_at | 0.2670 | 0.3907 | |
| GSE97050 | TPP1 | 1200 | A_33_P3324454 | 0.4593 | 0.1800 | |
| SRP007169 | TPP1 | 1200 | RNAseq | 0.9183 | 0.0637 | |
| SRP008496 | TPP1 | 1200 | RNAseq | 0.7134 | 0.0243 | |
| SRP064894 | TPP1 | 1200 | RNAseq | 0.8348 | 0.0000 | |
| SRP133303 | TPP1 | 1200 | RNAseq | 0.3638 | 0.0613 | |
| SRP159526 | TPP1 | 1200 | RNAseq | -0.0720 | 0.8040 | |
| SRP193095 | TPP1 | 1200 | RNAseq | 0.3118 | 0.0359 | |
| SRP219564 | TPP1 | 1200 | RNAseq | 0.4248 | 0.2558 | |
| TCGA | TPP1 | 1200 | RNAseq | 0.0232 | 0.5812 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPP1 | 1200 | 1 | 11 | 18 | |
| GSE20123 | TPP1 | 1200 | 1 | 11 | 18 | |
| GSE43470 | TPP1 | 1200 | 1 | 8 | 34 | |
| GSE46452 | TPP1 | 1200 | 7 | 8 | 44 | |
| GSE47630 | TPP1 | 1200 | 2 | 12 | 26 | |
| GSE54993 | TPP1 | 1200 | 3 | 1 | 66 | |
| GSE54994 | TPP1 | 1200 | 2 | 12 | 39 | |
| GSE60625 | TPP1 | 1200 | 0 | 0 | 11 | |
| GSE74703 | TPP1 | 1200 | 1 | 6 | 29 | |
| GSE74704 | TPP1 | 1200 | 0 | 8 | 12 | |
| TCGA | TPP1 | 1200 | 9 | 38 | 49 |
Total number of gains: 27; Total number of losses: 115; Total Number of normals: 346.
Somatic mutations of TPP1:
Generating mutation plots.
Highly correlated genes for TPP1:
Showing top 20/464 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPP1 | CCL21 | 0.813593 | 3 | 0 | 3 |
| TPP1 | F13A1 | 0.802453 | 3 | 0 | 3 |
| TPP1 | PTPRB | 0.743385 | 3 | 0 | 3 |
| TPP1 | GPC6 | 0.726282 | 4 | 0 | 3 |
| TPP1 | CHN2 | 0.720601 | 3 | 0 | 3 |
| TPP1 | ZFAND3 | 0.709767 | 3 | 0 | 3 |
| TPP1 | CCR10 | 0.707323 | 3 | 0 | 3 |
| TPP1 | IKZF1 | 0.696365 | 3 | 0 | 3 |
| TPP1 | NFATC2 | 0.691882 | 3 | 0 | 3 |
| TPP1 | CST7 | 0.691659 | 3 | 0 | 3 |
| TPP1 | GRAMD1A | 0.689424 | 4 | 0 | 4 |
| TPP1 | EMCN | 0.686729 | 3 | 0 | 3 |
| TPP1 | SMARCA2 | 0.68498 | 3 | 0 | 3 |
| TPP1 | HAUS1 | 0.682213 | 3 | 0 | 3 |
| TPP1 | EDN1 | 0.671655 | 3 | 0 | 3 |
| TPP1 | PLEKHG2 | 0.670649 | 3 | 0 | 3 |
| TPP1 | GLIS3 | 0.669877 | 5 | 0 | 5 |
| TPP1 | MRC1 | 0.661301 | 5 | 0 | 4 |
| TPP1 | NRGN | 0.66122 | 3 | 0 | 3 |
| TPP1 | KIF3C | 0.656417 | 3 | 0 | 3 |
For details and further investigation, click here
