| Full name: GPN-loop GTPase 1 | Alias Symbol: NTPBP|MBDIN|ATPBD1A|RPAP4 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 11321 | HGNC ID: HGNC:17030 | Ensembl Gene: ENSG00000198522 | OMIM ID: 611479 |
| Drug and gene relationship at DGIdb | |||
Expression of GPN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPN1 | 11321 | 209313_at | 0.2448 | 0.5793 | |
| GSE20347 | GPN1 | 11321 | 209313_at | 0.2780 | 0.0817 | |
| GSE23400 | GPN1 | 11321 | 209313_at | 0.2860 | 0.0000 | |
| GSE26886 | GPN1 | 11321 | 209313_at | 0.4516 | 0.0035 | |
| GSE29001 | GPN1 | 11321 | 209313_at | 0.0179 | 0.9435 | |
| GSE38129 | GPN1 | 11321 | 209313_at | 0.4658 | 0.0001 | |
| GSE45670 | GPN1 | 11321 | 209313_at | 0.4521 | 0.0259 | |
| GSE53622 | GPN1 | 11321 | 130458 | 0.3841 | 0.0000 | |
| GSE53624 | GPN1 | 11321 | 130458 | 0.3212 | 0.0000 | |
| GSE63941 | GPN1 | 11321 | 209313_at | 0.2470 | 0.5116 | |
| GSE77861 | GPN1 | 11321 | 209313_at | 0.2754 | 0.1468 | |
| GSE97050 | GPN1 | 11321 | A_23_P17144 | 0.4510 | 0.2130 | |
| SRP007169 | GPN1 | 11321 | RNAseq | -0.3190 | 0.3589 | |
| SRP008496 | GPN1 | 11321 | RNAseq | -0.2951 | 0.1408 | |
| SRP064894 | GPN1 | 11321 | RNAseq | 0.2835 | 0.0650 | |
| SRP133303 | GPN1 | 11321 | RNAseq | 0.5105 | 0.0054 | |
| SRP159526 | GPN1 | 11321 | RNAseq | 0.2611 | 0.1745 | |
| SRP193095 | GPN1 | 11321 | RNAseq | 0.1013 | 0.4060 | |
| SRP219564 | GPN1 | 11321 | RNAseq | -0.0504 | 0.8598 | |
| TCGA | GPN1 | 11321 | RNAseq | 0.1934 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPN1 | 11321 | 11 | 2 | 17 | |
| GSE20123 | GPN1 | 11321 | 11 | 2 | 17 | |
| GSE43470 | GPN1 | 11321 | 3 | 1 | 39 | |
| GSE46452 | GPN1 | 11321 | 2 | 4 | 53 | |
| GSE47630 | GPN1 | 11321 | 8 | 0 | 32 | |
| GSE54993 | GPN1 | 11321 | 0 | 6 | 64 | |
| GSE54994 | GPN1 | 11321 | 10 | 0 | 43 | |
| GSE60625 | GPN1 | 11321 | 0 | 3 | 8 | |
| GSE74703 | GPN1 | 11321 | 3 | 0 | 33 | |
| GSE74704 | GPN1 | 11321 | 9 | 1 | 10 | |
| TCGA | GPN1 | 11321 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.
Somatic mutations of GPN1:
Generating mutation plots.
Highly correlated genes for GPN1:
Showing top 20/1114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPN1 | MVP | 0.754551 | 3 | 0 | 3 |
| GPN1 | GSR | 0.749309 | 3 | 0 | 3 |
| GPN1 | TFCP2 | 0.743833 | 3 | 0 | 3 |
| GPN1 | STARD3NL | 0.730914 | 3 | 0 | 3 |
| GPN1 | TRAF7 | 0.728571 | 4 | 0 | 3 |
| GPN1 | ACAP2 | 0.725896 | 3 | 0 | 3 |
| GPN1 | CEP120 | 0.715205 | 3 | 0 | 3 |
| GPN1 | MTFP1 | 0.709854 | 3 | 0 | 3 |
| GPN1 | LYN | 0.69879 | 4 | 0 | 4 |
| GPN1 | SAMD1 | 0.695853 | 3 | 0 | 3 |
| GPN1 | HAS3 | 0.693131 | 4 | 0 | 4 |
| GPN1 | CTDSPL2 | 0.692145 | 3 | 0 | 3 |
| GPN1 | SEMA4B | 0.691692 | 3 | 0 | 3 |
| GPN1 | VPS13B | 0.690986 | 3 | 0 | 3 |
| GPN1 | CPSF3 | 0.68716 | 9 | 0 | 8 |
| GPN1 | DIP2B | 0.685066 | 4 | 0 | 3 |
| GPN1 | TMEM187 | 0.68259 | 3 | 0 | 3 |
| GPN1 | SLC4A1AP | 0.680961 | 13 | 0 | 11 |
| GPN1 | PARN | 0.675806 | 6 | 0 | 5 |
| GPN1 | RCN2 | 0.675187 | 7 | 0 | 5 |
For details and further investigation, click here
