LYN

 

Full name: LYN proto-oncogene, Src family tyrosine kinase Alias Symbol: JTK8
Type: protein-coding gene Cytoband: 8q12.1
Entrez ID: 4067 HGNC ID: HGNC:6735 Ensembl Gene: ENSG00000254087 OMIM ID: 165120
Drug and gene relationship at DGIdb

 

LYN involved pathways:

KEGG pathway Description View
hsa04062Chemokine signaling pathway
hsa04611Platelet activation
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04730Long-term depression
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05169Epstein-Barr virus infection

 

Expression of LYN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LYN 4067 210754_s_at 0.7801 0.3937
GSE20347 LYN 4067 202626_s_at 1.2534 0.0024
GSE23400 LYN 4067 210754_s_at 0.5371 0.0000
GSE26886 LYN 4067 202626_s_at -0.3565 0.4761
GSE29001 LYN 4067 202626_s_at 0.8700 0.0710
GSE38129 LYN 4067 210754_s_at 0.8454 0.0005
GSE45670 LYN 4067 202625_at 1.5974 0.0000
GSE53622 LYN 4067 24064 0.9644 0.0000
GSE53624 LYN 4067 24064 0.7174 0.0000
GSE63941 LYN 4067 210754_s_at 0.8357 0.4500
GSE77861 LYN 4067 210754_s_at 1.0066 0.1629
GSE97050 LYN 4067 A_23_P147431 1.5726 0.0620
SRP007169 LYN 4067 RNAseq 1.4438 0.0024
SRP008496 LYN 4067 RNAseq 0.5294 0.1862
SRP064894 LYN 4067 RNAseq 0.7617 0.0004
SRP133303 LYN 4067 RNAseq 0.7202 0.0000
SRP159526 LYN 4067 RNAseq 0.4541 0.4943
SRP193095 LYN 4067 RNAseq 0.7490 0.0005
SRP219564 LYN 4067 RNAseq 0.8326 0.0416
TCGA LYN 4067 RNAseq 0.2518 0.0029

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by LYN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LYN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LYN 4067 14 1 15
GSE20123 LYN 4067 14 1 15
GSE43470 LYN 4067 13 3 27
GSE46452 LYN 4067 20 3 36
GSE47630 LYN 4067 23 1 16
GSE54993 LYN 4067 1 16 53
GSE54994 LYN 4067 28 0 25
GSE60625 LYN 4067 0 4 7
GSE74703 LYN 4067 12 2 22
GSE74704 LYN 4067 10 0 10
TCGA LYN 4067 43 8 45

Total number of gains: 178; Total number of losses: 39; Total Number of normals: 271.  

 

Somatic mutations of LYN:

 

Generating mutation plots.

 

Highly correlated genes for LYN:

 

Showing top 20/809 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LYNTTC39C0.816548303
LYNHAUS10.796339303
LYNSFT2D30.748122303
LYNLOXL40.704909303
LYNMASTL0.701048404
LYNGPN10.69879404
LYNPOGLUT10.691805303
LYNMAP3K130.690018403
LYNTOMM220.687144303
LYNPAK10.684983403
LYNMRPL470.682618404
LYNAIMP20.681434404
LYNNFKB10.68139403
LYNGDPGP10.677823303
LYNXPO70.677548404
LYNSERPINA90.677474303
LYNHAS30.672371504
LYNHAVCR20.66986303
LYNSLC30A70.669136504
LYNABHD150.668902504

For details and further investigation, click here