| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 4 | Alias Symbol: KIAA0688|ADAMTS-2|ADMP-1 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 9507 | HGNC ID: HGNC:220 | Ensembl Gene: ENSG00000158859 | OMIM ID: 603876 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS4 | 9507 | 1555380_at | -0.2874 | 0.3520 | |
| GSE26886 | ADAMTS4 | 9507 | 1555380_at | 0.0991 | 0.4211 | |
| GSE45670 | ADAMTS4 | 9507 | 1555380_at | 0.0425 | 0.7348 | |
| GSE53622 | ADAMTS4 | 9507 | 95955 | 0.5038 | 0.0309 | |
| GSE53624 | ADAMTS4 | 9507 | 95955 | 0.6505 | 0.0002 | |
| GSE63941 | ADAMTS4 | 9507 | 1555380_at | 0.0239 | 0.9019 | |
| GSE77861 | ADAMTS4 | 9507 | 1555380_at | -0.1494 | 0.1300 | |
| GSE97050 | ADAMTS4 | 9507 | A_24_P128163 | 0.4262 | 0.2229 | |
| SRP007169 | ADAMTS4 | 9507 | RNAseq | 2.3476 | 0.0000 | |
| SRP008496 | ADAMTS4 | 9507 | RNAseq | 2.7379 | 0.0000 | |
| SRP064894 | ADAMTS4 | 9507 | RNAseq | -0.6999 | 0.2675 | |
| SRP133303 | ADAMTS4 | 9507 | RNAseq | 1.0307 | 0.0144 | |
| SRP159526 | ADAMTS4 | 9507 | RNAseq | 1.3117 | 0.1741 | |
| SRP193095 | ADAMTS4 | 9507 | RNAseq | 1.3929 | 0.0000 | |
| SRP219564 | ADAMTS4 | 9507 | RNAseq | -0.1961 | 0.7770 | |
| TCGA | ADAMTS4 | 9507 | RNAseq | -0.2340 | 0.0624 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ADAMTS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS4 | 9507 | 10 | 0 | 20 | |
| GSE20123 | ADAMTS4 | 9507 | 10 | 0 | 20 | |
| GSE43470 | ADAMTS4 | 9507 | 7 | 2 | 34 | |
| GSE46452 | ADAMTS4 | 9507 | 2 | 1 | 56 | |
| GSE47630 | ADAMTS4 | 9507 | 14 | 0 | 26 | |
| GSE54993 | ADAMTS4 | 9507 | 0 | 6 | 64 | |
| GSE54994 | ADAMTS4 | 9507 | 16 | 0 | 37 | |
| GSE60625 | ADAMTS4 | 9507 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS4 | 9507 | 7 | 2 | 27 | |
| GSE74704 | ADAMTS4 | 9507 | 4 | 0 | 16 | |
| TCGA | ADAMTS4 | 9507 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of ADAMTS4:
Generating mutation plots.
Highly correlated genes for ADAMTS4:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS4 | AVPR2 | 0.697208 | 3 | 0 | 3 |
| ADAMTS4 | GPR4 | 0.678976 | 4 | 0 | 4 |
| ADAMTS4 | LDHAL6A | 0.673575 | 3 | 0 | 3 |
| ADAMTS4 | CBLN4 | 0.668433 | 3 | 0 | 3 |
| ADAMTS4 | ANKRD34C | 0.659928 | 3 | 0 | 3 |
| ADAMTS4 | IL6 | 0.653567 | 3 | 0 | 3 |
| ADAMTS4 | ACRV1 | 0.649465 | 3 | 0 | 3 |
| ADAMTS4 | NHLRC4 | 0.647734 | 4 | 0 | 3 |
| ADAMTS4 | ITIH3 | 0.646161 | 3 | 0 | 3 |
| ADAMTS4 | ZFHX2 | 0.643995 | 3 | 0 | 3 |
| ADAMTS4 | TRIM10 | 0.643307 | 3 | 0 | 3 |
| ADAMTS4 | MYL4 | 0.640167 | 4 | 0 | 3 |
| ADAMTS4 | TNR | 0.638926 | 3 | 0 | 3 |
| ADAMTS4 | LMAN1L | 0.636311 | 3 | 0 | 3 |
| ADAMTS4 | HAS1 | 0.626337 | 4 | 0 | 4 |
| ADAMTS4 | STMN2 | 0.624812 | 3 | 0 | 3 |
| ADAMTS4 | PRX | 0.624752 | 3 | 0 | 3 |
| ADAMTS4 | CACNG8 | 0.623199 | 4 | 0 | 3 |
| ADAMTS4 | MT3 | 0.621109 | 4 | 0 | 3 |
| ADAMTS4 | RELN | 0.619755 | 3 | 0 | 3 |
For details and further investigation, click here
