| Full name: transmembrane protein 45B | Alias Symbol: BC016153|FLJ40787 | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 120224 | HGNC ID: HGNC:25194 | Ensembl Gene: ENSG00000151715 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM45B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM45B | 120224 | 226226_at | -1.8090 | 0.3441 | |
| GSE26886 | TMEM45B | 120224 | 226226_at | -3.3316 | 0.0000 | |
| GSE45670 | TMEM45B | 120224 | 230323_s_at | -0.3173 | 0.5350 | |
| GSE53622 | TMEM45B | 120224 | 17395 | -2.2280 | 0.0000 | |
| GSE53624 | TMEM45B | 120224 | 17395 | -2.9960 | 0.0000 | |
| GSE63941 | TMEM45B | 120224 | 226226_at | 1.5181 | 0.1818 | |
| GSE77861 | TMEM45B | 120224 | 226226_at | -0.9946 | 0.0148 | |
| GSE97050 | TMEM45B | 120224 | A_23_P1682 | -0.0509 | 0.9420 | |
| SRP007169 | TMEM45B | 120224 | RNAseq | -2.8150 | 0.0000 | |
| SRP008496 | TMEM45B | 120224 | RNAseq | -2.7546 | 0.0000 | |
| SRP064894 | TMEM45B | 120224 | RNAseq | -2.7409 | 0.0000 | |
| SRP133303 | TMEM45B | 120224 | RNAseq | -2.0814 | 0.0000 | |
| SRP159526 | TMEM45B | 120224 | RNAseq | -3.4709 | 0.0000 | |
| SRP193095 | TMEM45B | 120224 | RNAseq | -2.2744 | 0.0000 | |
| SRP219564 | TMEM45B | 120224 | RNAseq | -4.1350 | 0.0002 | |
| TCGA | TMEM45B | 120224 | RNAseq | -0.5567 | 0.0709 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by TMEM45B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM45B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM45B | 120224 | 0 | 13 | 17 | |
| GSE20123 | TMEM45B | 120224 | 0 | 13 | 17 | |
| GSE43470 | TMEM45B | 120224 | 2 | 7 | 34 | |
| GSE46452 | TMEM45B | 120224 | 3 | 26 | 30 | |
| GSE47630 | TMEM45B | 120224 | 2 | 19 | 19 | |
| GSE54993 | TMEM45B | 120224 | 10 | 0 | 60 | |
| GSE54994 | TMEM45B | 120224 | 5 | 19 | 29 | |
| GSE60625 | TMEM45B | 120224 | 0 | 3 | 8 | |
| GSE74703 | TMEM45B | 120224 | 1 | 5 | 30 | |
| GSE74704 | TMEM45B | 120224 | 0 | 9 | 11 | |
| TCGA | TMEM45B | 120224 | 6 | 50 | 40 |
Total number of gains: 29; Total number of losses: 164; Total Number of normals: 295.
Somatic mutations of TMEM45B:
Generating mutation plots.
Highly correlated genes for TMEM45B:
Showing top 20/1282 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM45B | CYSRT1 | 0.834439 | 6 | 0 | 6 |
| TMEM45B | CAPN14 | 0.82642 | 6 | 0 | 6 |
| TMEM45B | SH3PXD2A-AS1 | 0.8221 | 4 | 0 | 4 |
| TMEM45B | STX7 | 0.798748 | 3 | 0 | 3 |
| TMEM45B | GRHL1 | 0.798258 | 8 | 0 | 8 |
| TMEM45B | TMEM40 | 0.795629 | 8 | 0 | 8 |
| TMEM45B | PRSS3 | 0.794358 | 8 | 0 | 7 |
| TMEM45B | GLTP | 0.794353 | 6 | 0 | 6 |
| TMEM45B | TMPRSS11D | 0.786424 | 8 | 0 | 7 |
| TMEM45B | SLC13A4 | 0.784533 | 6 | 0 | 6 |
| TMEM45B | ATG9B | 0.784216 | 7 | 0 | 7 |
| TMEM45B | TMPRSS11E | 0.783698 | 8 | 0 | 8 |
| TMEM45B | CERS3 | 0.783108 | 6 | 0 | 6 |
| TMEM45B | TGM1 | 0.78155 | 9 | 0 | 8 |
| TMEM45B | GRPEL2 | 0.779055 | 7 | 0 | 7 |
| TMEM45B | TTC9 | 0.778458 | 8 | 0 | 8 |
| TMEM45B | RAB27B | 0.776719 | 6 | 0 | 6 |
| TMEM45B | CLIC3 | 0.775457 | 6 | 0 | 6 |
| TMEM45B | FUT3 | 0.775415 | 8 | 0 | 7 |
| TMEM45B | SPAG17 | 0.774745 | 5 | 0 | 5 |
For details and further investigation, click here
