| Full name: gap junction protein beta 6 | Alias Symbol: EDH|HED|CX30 | ||
| Type: protein-coding gene | Cytoband: 13q12.11 | ||
| Entrez ID: 10804 | HGNC ID: HGNC:4288 | Ensembl Gene: ENSG00000121742 | OMIM ID: 604418 |
| Drug and gene relationship at DGIdb | |||
Expression of GJB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GJB6 | 10804 | 231771_at | -1.2919 | 0.5887 | |
| GSE26886 | GJB6 | 10804 | 231771_at | -2.4761 | 0.0008 | |
| GSE45670 | GJB6 | 10804 | 231771_at | 0.2707 | 0.2617 | |
| GSE53622 | GJB6 | 10804 | 46208 | -0.8375 | 0.0300 | |
| GSE53624 | GJB6 | 10804 | 46208 | -1.4066 | 0.0000 | |
| GSE63941 | GJB6 | 10804 | 231771_at | 2.7675 | 0.1536 | |
| GSE77861 | GJB6 | 10804 | 231771_at | -0.6993 | 0.3673 | |
| GSE97050 | GJB6 | 10804 | A_23_P2745 | 0.0768 | 0.9554 | |
| SRP007169 | GJB6 | 10804 | RNAseq | -2.8216 | 0.0000 | |
| SRP008496 | GJB6 | 10804 | RNAseq | -1.7368 | 0.0001 | |
| SRP064894 | GJB6 | 10804 | RNAseq | -0.4047 | 0.5158 | |
| SRP133303 | GJB6 | 10804 | RNAseq | -0.1695 | 0.7951 | |
| SRP159526 | GJB6 | 10804 | RNAseq | -1.7777 | 0.0617 | |
| SRP219564 | GJB6 | 10804 | RNAseq | -2.6915 | 0.0277 | |
| TCGA | GJB6 | 10804 | RNAseq | 1.3861 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by GJB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GJB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GJB6 | 10804 | 1 | 16 | 13 | |
| GSE20123 | GJB6 | 10804 | 1 | 15 | 14 | |
| GSE43470 | GJB6 | 10804 | 1 | 13 | 29 | |
| GSE46452 | GJB6 | 10804 | 0 | 33 | 26 | |
| GSE47630 | GJB6 | 10804 | 3 | 26 | 11 | |
| GSE54993 | GJB6 | 10804 | 11 | 2 | 57 | |
| GSE54994 | GJB6 | 10804 | 1 | 13 | 39 | |
| GSE60625 | GJB6 | 10804 | 0 | 3 | 8 | |
| GSE74703 | GJB6 | 10804 | 1 | 10 | 25 | |
| GSE74704 | GJB6 | 10804 | 0 | 13 | 7 | |
| TCGA | GJB6 | 10804 | 7 | 42 | 47 |
Total number of gains: 26; Total number of losses: 186; Total Number of normals: 276.
Somatic mutations of GJB6:
Generating mutation plots.
Highly correlated genes for GJB6:
Showing top 20/611 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GJB6 | GJB2 | 0.832094 | 7 | 0 | 7 |
| GJB6 | GPR45 | 0.80232 | 3 | 0 | 3 |
| GJB6 | KRT6B | 0.752568 | 9 | 0 | 9 |
| GJB6 | S100A12 | 0.751982 | 6 | 0 | 6 |
| GJB6 | CTNNBIP1 | 0.732258 | 3 | 0 | 3 |
| GJB6 | PRDM1 | 0.726656 | 6 | 0 | 6 |
| GJB6 | PARD6G | 0.724695 | 4 | 0 | 4 |
| GJB6 | KRT83 | 0.718199 | 3 | 0 | 3 |
| GJB6 | KRT6C | 0.71786 | 4 | 0 | 3 |
| GJB6 | KRT80 | 0.715805 | 5 | 0 | 5 |
| GJB6 | PLS3 | 0.714165 | 6 | 0 | 6 |
| GJB6 | ARAP2 | 0.711308 | 3 | 0 | 3 |
| GJB6 | DSC2 | 0.709948 | 9 | 0 | 8 |
| GJB6 | CNFN | 0.709866 | 7 | 0 | 7 |
| GJB6 | ACTR3 | 0.699674 | 3 | 0 | 3 |
| GJB6 | LPAR5 | 0.699097 | 8 | 0 | 6 |
| GJB6 | MALL | 0.697259 | 7 | 0 | 7 |
| GJB6 | PGLYRP3 | 0.69441 | 5 | 0 | 4 |
| GJB6 | SPRR1B | 0.693921 | 9 | 0 | 7 |
| GJB6 | SPRR2D | 0.692775 | 4 | 0 | 3 |
For details and further investigation, click here
