| Full name: nuclear factor, erythroid 2 like 3 | Alias Symbol: Nrf3 | ||
| Type: protein-coding gene | Cytoband: 7p15.2 | ||
| Entrez ID: 9603 | HGNC ID: HGNC:7783 | Ensembl Gene: ENSG00000050344 | OMIM ID: 604135 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NFE2L3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFE2L3 | 9603 | 204702_s_at | 0.9137 | 0.2719 | |
| GSE20347 | NFE2L3 | 9603 | 204702_s_at | 1.1264 | 0.0005 | |
| GSE23400 | NFE2L3 | 9603 | 204702_s_at | 0.3801 | 0.0007 | |
| GSE26886 | NFE2L3 | 9603 | 204702_s_at | 1.8844 | 0.0000 | |
| GSE29001 | NFE2L3 | 9603 | 204702_s_at | 0.8794 | 0.1629 | |
| GSE38129 | NFE2L3 | 9603 | 204702_s_at | 1.6896 | 0.0000 | |
| GSE45670 | NFE2L3 | 9603 | 204702_s_at | 1.1550 | 0.0013 | |
| GSE53622 | NFE2L3 | 9603 | 11273 | 1.2526 | 0.0000 | |
| GSE53624 | NFE2L3 | 9603 | 11273 | 1.2234 | 0.0000 | |
| GSE63941 | NFE2L3 | 9603 | 204702_s_at | 1.7522 | 0.0818 | |
| GSE77861 | NFE2L3 | 9603 | 204702_s_at | 1.3352 | 0.0879 | |
| GSE97050 | NFE2L3 | 9603 | A_23_P42718 | 0.8163 | 0.1057 | |
| SRP007169 | NFE2L3 | 9603 | RNAseq | 0.5136 | 0.3820 | |
| SRP008496 | NFE2L3 | 9603 | RNAseq | 1.1729 | 0.0148 | |
| SRP064894 | NFE2L3 | 9603 | RNAseq | 0.7291 | 0.0021 | |
| SRP133303 | NFE2L3 | 9603 | RNAseq | 0.6813 | 0.0000 | |
| SRP159526 | NFE2L3 | 9603 | RNAseq | 1.6128 | 0.0018 | |
| SRP193095 | NFE2L3 | 9603 | RNAseq | 0.6038 | 0.0002 | |
| SRP219564 | NFE2L3 | 9603 | RNAseq | 1.6182 | 0.0032 | |
| TCGA | NFE2L3 | 9603 | RNAseq | 0.3920 | 0.0005 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by NFE2L3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFE2L3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFE2L3 | 9603 | 16 | 1 | 13 | |
| GSE20123 | NFE2L3 | 9603 | 16 | 1 | 13 | |
| GSE43470 | NFE2L3 | 9603 | 4 | 0 | 39 | |
| GSE46452 | NFE2L3 | 9603 | 10 | 2 | 47 | |
| GSE47630 | NFE2L3 | 9603 | 9 | 1 | 30 | |
| GSE54993 | NFE2L3 | 9603 | 0 | 6 | 64 | |
| GSE54994 | NFE2L3 | 9603 | 21 | 2 | 30 | |
| GSE60625 | NFE2L3 | 9603 | 0 | 0 | 11 | |
| GSE74703 | NFE2L3 | 9603 | 4 | 0 | 32 | |
| GSE74704 | NFE2L3 | 9603 | 10 | 1 | 9 | |
| TCGA | NFE2L3 | 9603 | 55 | 6 | 35 |
Total number of gains: 145; Total number of losses: 20; Total Number of normals: 323.
Somatic mutations of NFE2L3:
Generating mutation plots.
Highly correlated genes for NFE2L3:
Showing top 20/1565 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFE2L3 | PWP1 | 0.775261 | 3 | 0 | 3 |
| NFE2L3 | TTYH2 | 0.72535 | 3 | 0 | 3 |
| NFE2L3 | GPR65 | 0.72219 | 3 | 0 | 3 |
| NFE2L3 | KRTCAP2 | 0.720202 | 3 | 0 | 3 |
| NFE2L3 | ZBED4 | 0.717265 | 3 | 0 | 3 |
| NFE2L3 | UBE2T | 0.715322 | 8 | 0 | 8 |
| NFE2L3 | SPNS1 | 0.709751 | 3 | 0 | 3 |
| NFE2L3 | SSBP4 | 0.707749 | 3 | 0 | 3 |
| NFE2L3 | SPAG5 | 0.706404 | 11 | 0 | 11 |
| NFE2L3 | INTS10 | 0.704916 | 3 | 0 | 3 |
| NFE2L3 | TMTC3 | 0.700514 | 4 | 0 | 3 |
| NFE2L3 | MGAT4B | 0.696828 | 3 | 0 | 3 |
| NFE2L3 | SPAST | 0.695994 | 9 | 0 | 7 |
| NFE2L3 | BUB1 | 0.694581 | 10 | 0 | 9 |
| NFE2L3 | NCAPD2 | 0.69078 | 12 | 0 | 11 |
| NFE2L3 | DHRS13 | 0.685889 | 5 | 0 | 4 |
| NFE2L3 | PDIA4 | 0.682225 | 8 | 0 | 8 |
| NFE2L3 | C1orf112 | 0.682125 | 10 | 0 | 10 |
| NFE2L3 | RPGR | 0.681838 | 3 | 0 | 3 |
| NFE2L3 | C1orf131 | 0.678899 | 7 | 0 | 7 |
For details and further investigation, click here
