| Full name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | Alias Symbol: PST|PST1 | ||
| Type: protein-coding gene | Cytoband: 5q21.1 | ||
| Entrez ID: 7903 | HGNC ID: HGNC:10871 | Ensembl Gene: ENSG00000113532 | OMIM ID: 602547 |
| Drug and gene relationship at DGIdb | |||
Expression of ST8SIA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ST8SIA4 | 7903 | 230836_at | 0.5652 | 0.5150 | |
| GSE20347 | ST8SIA4 | 7903 | 206925_at | 0.0488 | 0.5568 | |
| GSE23400 | ST8SIA4 | 7903 | 206925_at | -0.0498 | 0.1316 | |
| GSE26886 | ST8SIA4 | 7903 | 230261_at | -0.5038 | 0.0744 | |
| GSE29001 | ST8SIA4 | 7903 | 206925_at | 0.0307 | 0.8255 | |
| GSE38129 | ST8SIA4 | 7903 | 206925_at | -0.0240 | 0.7227 | |
| GSE45670 | ST8SIA4 | 7903 | 230836_at | -0.2385 | 0.5983 | |
| GSE53622 | ST8SIA4 | 7903 | 5587 | 0.1525 | 0.3425 | |
| GSE53624 | ST8SIA4 | 7903 | 5587 | 0.2201 | 0.2090 | |
| GSE63941 | ST8SIA4 | 7903 | 206925_at | 0.6193 | 0.6811 | |
| GSE77861 | ST8SIA4 | 7903 | 206925_at | -0.0417 | 0.6645 | |
| GSE97050 | ST8SIA4 | 7903 | A_33_P3291484 | 0.4449 | 0.1752 | |
| SRP007169 | ST8SIA4 | 7903 | RNAseq | 0.8789 | 0.1021 | |
| SRP008496 | ST8SIA4 | 7903 | RNAseq | 0.6191 | 0.1068 | |
| SRP064894 | ST8SIA4 | 7903 | RNAseq | 0.7447 | 0.0050 | |
| SRP133303 | ST8SIA4 | 7903 | RNAseq | 0.2424 | 0.3378 | |
| SRP159526 | ST8SIA4 | 7903 | RNAseq | 0.5535 | 0.3389 | |
| SRP193095 | ST8SIA4 | 7903 | RNAseq | 0.5040 | 0.0127 | |
| SRP219564 | ST8SIA4 | 7903 | RNAseq | 1.1909 | 0.0036 | |
| TCGA | ST8SIA4 | 7903 | RNAseq | 0.1453 | 0.2960 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ST8SIA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ST8SIA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ST8SIA4 | 7903 | 1 | 13 | 16 | |
| GSE20123 | ST8SIA4 | 7903 | 1 | 13 | 16 | |
| GSE43470 | ST8SIA4 | 7903 | 2 | 9 | 32 | |
| GSE46452 | ST8SIA4 | 7903 | 0 | 28 | 31 | |
| GSE47630 | ST8SIA4 | 7903 | 0 | 20 | 20 | |
| GSE54993 | ST8SIA4 | 7903 | 8 | 1 | 61 | |
| GSE54994 | ST8SIA4 | 7903 | 1 | 18 | 34 | |
| GSE60625 | ST8SIA4 | 7903 | 0 | 0 | 11 | |
| GSE74703 | ST8SIA4 | 7903 | 1 | 7 | 28 | |
| GSE74704 | ST8SIA4 | 7903 | 1 | 7 | 12 | |
| TCGA | ST8SIA4 | 7903 | 4 | 43 | 49 |
Total number of gains: 19; Total number of losses: 159; Total Number of normals: 310.
Somatic mutations of ST8SIA4:
Generating mutation plots.
Highly correlated genes for ST8SIA4:
Showing top 20/506 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ST8SIA4 | SNX20 | 0.789766 | 6 | 0 | 6 |
| ST8SIA4 | ARHGAP9 | 0.782153 | 6 | 0 | 6 |
| ST8SIA4 | SAMSN1 | 0.760433 | 6 | 0 | 6 |
| ST8SIA4 | CERKL | 0.756393 | 3 | 0 | 3 |
| ST8SIA4 | CHST11 | 0.75577 | 3 | 0 | 3 |
| ST8SIA4 | PTPRC | 0.753021 | 5 | 0 | 5 |
| ST8SIA4 | PIK3AP1 | 0.749832 | 5 | 0 | 5 |
| ST8SIA4 | TYROBP | 0.748642 | 5 | 0 | 5 |
| ST8SIA4 | GPR65 | 0.735825 | 7 | 0 | 6 |
| ST8SIA4 | CCL21 | 0.735648 | 3 | 0 | 3 |
| ST8SIA4 | ARHGDIB | 0.73341 | 6 | 0 | 6 |
| ST8SIA4 | GNGT2 | 0.730546 | 4 | 0 | 4 |
| ST8SIA4 | CLEC14A | 0.728949 | 3 | 0 | 3 |
| ST8SIA4 | CSF2RB | 0.725884 | 6 | 0 | 6 |
| ST8SIA4 | FLI1 | 0.724943 | 8 | 0 | 8 |
| ST8SIA4 | GIMAP5 | 0.724784 | 3 | 0 | 3 |
| ST8SIA4 | CD69 | 0.716587 | 4 | 0 | 4 |
| ST8SIA4 | MNDA | 0.715917 | 7 | 0 | 7 |
| ST8SIA4 | GIMAP4 | 0.714582 | 6 | 0 | 6 |
| ST8SIA4 | MS4A6A | 0.713435 | 6 | 0 | 6 |
For details and further investigation, click here
